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Medical Physics | 1989

A comparison using tissue electrical properties and temperature rise to determine relative absorption of microwave power in malignant tissue

William T. Joines; Shashi Shrivastav; Randy L. Jirtle

This paper compares two methods for determining the radio frequency absorbed power in tissue: from the measured electrical properties of the tissue, and from the induced temperature rise per unit time. In previous research, we measured the ratio frequency electrical properties of muscle, mammary gland, and malignant mammary tissue (SMT-2A mammary adenocarcinoma) in female W/Fu isogeneic rats. From those measurements we calculated for each tissue the power absorption versus frequency, and formed the ratio of malignant-to-normal power absorption. This ratio exhibited a peak within the 150 to 400 MHz range, indicating a selective absorption of power in this type of malignant tissue over that of the normal host tissue. In the present study, by an entirely different method, we have directly tested the results of our earlier research. We filled a 20-cm-long section of rigid coaxial line (ordinarily air filled) with either normal (beef muscle or fat) or malignant (SMT-2A) tissue, and measured the temperature increase versus time at the irradiated tissue surface for the same absorbed power in each tissue type. We made the measurements from 50 to 915 MHz, and found that the initial temperature increase per second per watt absorbed (dT/dt/Pa) was greater in malignant tissue than in muscle or fat at each frequency tested, with the greatest differences occurring below 450 MHz. Power absorption based on the measured values of dT/dt/Pa was again greatest for the malignant tissue (SMT-2A mammary adenocarcinoma) within the 150 to 400 MHz range.


The Journal of Urology | 1981

In Vitro Chemotherapeutic Testing of Urologic Tumors

John Day; Shashi Shrivastav; Gerald Lin; R. A. Bonar; David F. Paulson

We studied 20 transitional cell tumors of the bladder and 25 adenocarcinomas of the kidney in vitro to determine their chemotherapeutic sensitivity. The different sensitivity patterns among the individual tumors were demonstrated. Identical drug sensitivity patterns could be identified in the primary and metastatic sites, and in tumor tissue removed from the primary and metastatic deposits in the same patient. Human renal adenocarcinoma maintained in the athymic mouse demonstrated identical chemotherapeutic sensitivity patterns in vitro and in vivo. Our data would support that these in vitro chemotherapy studies may assist in the selection of agents to use in human tumor-bearing hosts.


In Vitro Cellular & Developmental Biology – Plant | 1981

Establishment and characterization of a cell line (SS78) from a human renal cell carcinoma

Shashi Shrivastav; Yousuf Sharief; John Day; Charles F. Reich; R. A. Bonar

SummaryA new cell line, SS78, was established from a primary renal cell carcinoma of a Caucasian male. The tissue was dispersed with collagenase, and viable cells were separated by flotation on a Ficoll-Hypaque gradient. In culture, the SS78 cells retained a distinct epithelial morphology, and no fibroblastlike cells were seen. The cultured cells were aneuploid with a modal chromosome number of 80 and had several marker chromosomes. Inoculation of the cultured cells into athymic nude mice caused tumors at the sites of inoculation.


Cancer Research | 1982

Effect of Verapamil on Malignant Tissue Blood Flow in SMT-2A Tumor-bearing Rats

William G. Kaelin; Shashi Shrivastav; David G. Shand; Randy L. Jirtie


Cancer Research | 1990

Innovations That Influence the Pharmacology of Monoclonal Antibody Guided Tumor Targeting

Jeffrey Schlom; Patricia Horan Hand; John W. Greiner; David Colcher; Shashi Shrivastav; Jorge A. Carrasquillo; James C. Reynolds; Steven M. Larson; Andrew Raubitschek


Cancer Research | 1984

Blood Flow to Primary Tumors and Lymph Node Metastases in SMT-2A Tumor-bearing Rats following Intravenous Flunarizine

William G. Kaelin; Shashi Shrivastav; Randy L. Jirtle


Cancer Research | 1983

Microwave Hyperthermia and Its Effect on Tumor Blood Flow in Rats

Shashi Shrivastav; William G. Kaelin; William T. Joines; Randy L. Jirtle


Cancer Research | 1980

An in Vitro Assay Procedure to Test Chemotherapeutic Drugs on Cells from Human Solid Tumors

Shashi Shrivastav; R. A. Bonar; Kenneth R. Stone; David F. Paulson


Cancer Research | 1985

Effect of 5-Hydroxytryptamine on Tissue Blood Flow and Microwave Heating of Rat Tumors

Shashi Shrivastav; William T. Joines; Randy L. Jirtle


Cancer Research | 1980

Activation of Cyclophosphamide for in Vitro Testing of Cell Sensitivity

Shashi Shrivastav; Kenneth R. Stone; David F. Paulson; R. A. Bonar

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Randy L. Jirtle

University of Wisconsin-Madison

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Andrew Raubitschek

City of Hope National Medical Center

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David Colcher

City of Hope National Medical Center

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