Shaukat Shuja

Substituted benzenediol Schiff bases as promising new anti-glycation agents.

A feature of diabetes is that the rate of protein glycation and the formation of advanced glycation endproducts (AGEs) increases spontaneously due to the abnormally elevated levels of sugar in the blood. The glycation of proteins is associated with a large number of late diabetic complications (retinopathy, neuropathy, atherosclerosis, end stage renal diseases, rheumatoid arthritis and neurodegenerative diseases). The increase in diabetic complications is a major cause of morbidity and mortality, which has increased significantly in the last two decades. Therefore, there is a considerable recent interest in the identification of lead molecules, which can inhibit the glycation process or slow it down considerably. A new class of anti-glycation agents has been identified, based on the spectrofluorimetric analysis of fluorescent advanced glycation endproducts (AGEs), benzenediol Schiff bases, and their structure-activity relationships have been studied. Some of these compounds have shown a promising anti-glycation potential in vitro.

N-formyl-N '-(2-oxidobenzylidene) hydrazine-kappa(3) O, N, O '] diphenyltin(IV)

The title compound, [Sn(C6H5)(2)(C8H6N2O2)], features a five-coordinate C2NO2 coordination geometry for Sn that is intermediate between trigonal-bipyramidal and square-pyramidal.

catena-Poly[[trimethyl­tin(IV)]-μ-4-[1-(2-hydroxy­phen­yl)ethyl­ideneamino­meth­yl]cyclo­hexa­necarboxyl­ato-κ2O:O′]

In the zigzag polymeric title compound, [Sn(CH3)3(C16H20NO3)]n, the Sn atom adopts a distorted trigonal–bipyramidal geometry.

Dieth­yl[N-(3-meth­oxy-2-oxidobenzyl­idene)-N′-(oxidomethyl­ene)hydrazine-κ3O,N,O′]tin(IV)

In the molecule of the title compound, [Sn(C2H5)2(C9H8N2O3)], the Sn atom is five-coordinated in a distorted trigonal-bipyramidal configuration by two O and one N atoms of the tridentate Schiff base ligand in the equatorial plane, and by two C atoms of ethyl groups in the axial positions. In the crystal structure, intermolecular C—H⋯O hydrogen bonds link the molecules into centrosymmetric dimers.

2-Hydroxy-6-[(m-tolyliminio)methyl]phenolate

In the solid state, the title compound, C14H13NO2, crystallizes as a zwitterion. Two molecules comprise the asymmetric unit. The molecules exhibit two types of hydrogen bonds: N-H center dot center dot center dot O hydrogen bonds involving hydroxy and imine groups generate an S(6) ring motif, and O-H center dot center dot center dot O hydrogen bonds linking two symmetry-related molecules form a centrosymmetric dimer.

(2,2'-Bipyridine-κN,N'){[(3-meth-oxy-2-oxidobenzyl-idene-κO)hydrazono]methano-lato-κN,O}dimethyl-tin(IV).

In the crystal structure of the title compound, [Sn(CH3)2(C9H8N2O3)(C10H8N2)], the Sn atom exhibits a pentagonal bipyramidal coordination geometry defined by two C, three N and two O atoms. The bond distances for Sn—C, Sn—N and Sn—O are in the ranges 2.097 (3)–2.098 (3), 2.298 (2)–2.623 (2) and 2.157 (2)–2.266 (2) Å, respectively. The molecular structure of the monomeric compound is stabilized by three intramolecular C—H⋯O hydrogen bonds, all involving bipyridine C—H groups.

(2,2′-Bipyridine-κ2 N,N′){[(3-meth­oxy-2-oxidobenzyl­idene-κO 2)hydrazono]methano­lato-κ2 N 2,O}dimethyl­tin(IV)

In the crystal structure of the title compound, [Sn(CH3)2(C9H8N2O3)(C10H8N2)], the Sn atom exhibits a pentagonal bipyramidal coordination geometry defined by two C, three N and two O atoms. The bond distances for Sn—C, Sn—N and Sn—O are in the ranges 2.097 (3)–2.098 (3), 2.298 (2)–2.623 (2) and 2.157 (2)–2.266 (2) Å, respectively. The molecular structure of the monomeric compound is stabilized by three intramolecular C—H⋯O hydrogen bonds, all involving bipyridine C—H groups.

(2,2′-Bipyridine-κ2N,N′){[(3-meth­oxy-2-oxidobenzyl­idene-κO2)hydrazono]methano­lato-κ2N2,O}dimethyl­tin(IV)

In the crystal structure of the title compound, [Sn(CH3)2(C9H8N2O3)(C10H8N2)], the Sn atom exhibits a pentagonal bipyramidal coordination geometry defined by two C, three N and two O atoms. The bond distances for Sn—C, Sn—N and Sn—O are in the ranges 2.097 (3)–2.098 (3), 2.298 (2)–2.623 (2) and 2.157 (2)–2.266 (2) Å, respectively. The molecular structure of the monomeric compound is stabilized by three intramolecular C—H⋯O hydrogen bonds, all involving bipyridine C—H groups.

3-[3-(trifluoromethyl)phenyliminomethyl]benzene-1,2-diol

The crystal packing of the essentially planar molecules of the title compound, C14H10F3NO2, is stabilized by O - (HO)-O-... hydrogen bonds and possible C - (HO)-O-... and C - (HF)-F-... interactions.