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Shaun R. Stauffer

United States Military Academy

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Publication

Featured researches published by Shaun R. Stauffer.

ChemMedChem | 2009

Evolution of tertiary carbinamine BACE-1 inhibitors: Aβ reduction in rhesus CSF upon oral dosing

Philippe G. Nantermet; Hemaka A. Rajapakse; Mathew Stanton; Shaun R. Stauffer; James C. Barrow; Allison R. Gregro; Keith P. Moore; Melissa A. Steinbeiser; John Swestock; Harold G. Selnick; Samuel L. Graham; Georgia B. McGaughey; Dennis Colussi; Ming Tain Lai; Sethu Sankaranarayanan; Adam J. Simon; Sanjeev Munshi; Jacquelynn J. Cook; Marie A. Holahan; Maria S. Michener; Joseph P. Vacca

Evolution of Tertiary Carbinamine BACE-1 Inhibitors: Ab Reduction in Rhesus CSF upon Oral Dosing Philippe G. Nantermet,* Hemaka A. Rajapakse, Mathew G. Stanton, Shaun R. Stauffer, James C. Barrow, Allison R. Gregro, Keith P. Moore, Melissa A. Steinbeiser, John Swestock, Harold G. Selnick, Samuel L. Graham, Georgia B. McGaughey, Dennis Colussi, Ming-Tain Lai, Sethu Sankaranarayanan, Adam J. Simon, Sanjeev Munshi, Jacquelynn J. Cook, Marie A. Holahan, Maria S. Michener, and Joseph P. Vacca

Bioorganic & Medicinal Chemistry Letters | 2007

Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation

Shaun R. Stauffer; Matthew Stanton; Alison R. Gregro; Melissa A. Steinbeiser; Jennifer R. Shaffer; Philippe G. Nantermet; James C. Barrow; Kenneth E. Rittle; Dennis Collusi; Amy S. Espeseth; Ming Tain Lai; Beth Pietrak; M. Katharine Holloway; Georgia B. McGaughey; Sanjeev Munshi; Jerome H. Hochman; Adam J. Simon; Harold G. Selnick; Samuel L. Graham; Joseph P. Vacca

Bioorganic & Medicinal Chemistry Letters | 2007

β-Secretase (BACE-1) inhibitors: Accounting for 10s loop flexibility using rigid active sites

Georgia B. McGaughey; Dennis Colussi; Samuel L. Graham; Ming-Tain Lai; Sanjeev Munshi; Philippe G. Nantermet; Beth Pietrak; Hemaka A. Rajapakse; Harold G. Selnick; Shaun R. Stauffer; M. Katharine Holloway

Tetrahedron Letters | 2005

Pd-catalyzed amination in a polar medium: rate enhancement, convenient product isolation, and tandem Suzuki cross-coupling

Shaun R. Stauffer; Melissa A. Steinbeiser

Alzheimers & Dementia | 2008

O1-04-02: Significant Aβ lowering in CSF and plasma after oral administration of a potent small molecule BACE1 inhibitor in non-human primates

Adam J. Simon; Marie Holihan; Guoxin Wu; Maria S. Michener; Diane Posavec; Ming-Tan Lai; Dennis Colussi; Eric A. Price; Kate Tugusheva; Jacky Wong; Guy Seabrook; Dave Gilberto; Joan D. Ellis; MaryBeth Young; Keith P. Moore; Shaun R. Stauffer; Hemaka A. Rajapakse; Matt Stanton; Harold G. Selnick; Georgia B. McGaughey; Phillipe Nantermet; Sam Graham; Joseph P. Vacca; Sethu Sankaranarayanan; Jacquelynn J. Cook

Archive | 2007

Inhibiteurs de spiropipéridine macrocyclique de bêta-secrétase pour le traitement de la maladie d'alzheimer

M. Katharine Holloway; Keith P. Moore; Philippe G. Nantermet; Shaun R. Stauffer

Archive | 2006

Als inhibitoren von beta-secretase aktive tertiäre carbinamine mit substituierten heterocyclen zur behandlung der alzheimer-krankheit As inhibitors of beta-secretase active tertiary carbinamine with substituted heterocycles for the treatment of alzheimer's disease

Georgia B Mcgaughey; Philippe G. Nantermet; Hemaka A. Rajapakse; Shaun R. Stauffer

Archive | 2006

Inhibiteurs de spiropiperidine beta-secretase pour le traitement de la maladie d'alzheimer

Craig A. Coburn; Melissa S. Egbertson; Bruce Fahr; Samuel L. Graham; Wanli Lu; Georgia B Mcgaughey; Philippe G. Nantermet; Hemaka A. Rajapakse; Shawn R. Stachel; Shaun R. Stauffer; Wenjin Yang

Archive | 2006

Inhibiteurs de beta-secretase de spiropiperidine destines au traitement de la maladie d'alzheimer

Craig A. Coburn; Melissa S. Egbertson; Samuel L. Graham; Georgia B Mcgaughey; Shaun R. Stauffer; Wenjin Yang; Wanli Lu; Bruce Fahr

Archive | 2006

Aminomethyl-beta-sekretase-hemmer zur behandlung von alzheimer

Craig A. Coburn; Philippe G. Nantermet; Hemaka A. Rajapakse; Harold G. Selnick; Shaun R. Stauffer

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Collaboration

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Philippe G. Nantermet

Merck

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Harold G. Selnick

Merck

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Hemaka A. Rajapakse

United States Military Academy

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Craig A. Coburn

United States Military Academy

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Georgia B Mcgaughey

University of Colorado Boulder

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James C. Barrow

University of Pennsylvania

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Joseph P. Vacca

Merck

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Matthew G. Stanton

Merck

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Samuel L. Graham

United States Military Academy

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Shawn J. Stachel

United States Military Academy

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