Shawn P. Allwein

C-Glycosides to fused polycyclic ethers

This manuscript describes the synthesis of fused polycyclic ethers from the coupling of C-glycoside forming reactions with ring closing metathesis and acid mediated annulation reactions.

Enol ether–olefin ring closing metathesis using the Grubbs ruthenium imidazole catalyst

Abstract This letter reports our successful use of the Grubbs ruthenium imidazole alkylidene catalyst in enol ether–olefin ring closing metathesis reactions.

A highly efficient iterative approach to fused ether ring systems

Abstract An iterative synthesis of fused ether ring systems has been developed. This strategy couples a cyclic enol ether oxidation and carbon-carbon bond forming reaction in one flask with an acid catalyzed cyclic acetal formation and alkoxide elimination in another flask. The result is a general and highly efficient two flask synthesis of fused ethers as are present in a wide variety of bioactive natural products.