Sheldon C. Sommers

Biopsy diagnosis of the digestive tract

Volume 1: procedures esophagus stomach duodenum. Volume 2: small intestine large intestine anal canal.

Histologic differences in breast carcinoma of Japanese and American women

Series of breast carcinoma cases from Nagoya, Japan, and New York were compared histologically. Japanese women showed significantly more lymphocytic infiltration around invasive mammary carcinomas (p < 0.01), confirming previous studies, a finding suggestive of greater host resistance to breast cancer among Japanese women. Cancer 33:1577–1579, 1974.

Lung carcinoma arising in bronchopulmonary sequestration.

A squamous cell carcinoma arising in intralobar bronchopulmonary sequestration of the right lower lobe is described in a 69‐year‐old man. One other reported case was found. Other complications of bronchopulmonary sequestration include nonspecific infections and tuberculosis.

Alimentary tract biopsy lesions in the acquired immune deficiency syndrome.

&NA; The surgical pathology of the alimentary tract complications of the acquired immune deficiency syndrome (AIDS) is described and illustrated by a review of one years material accessioned at a New York Community Hospital. Cytomegalovirus, Cryptosporidium and Mycobacterium avium‐intracellulare were particularly notable among diverse opportunistic infectious agents. Visceral Kaposis sarcoma and malignant lymphomas were the principal malignancies recognized, and their occurrence in young men should alert clinicians to the possibility of AIDS.

Pathology of the stomach and duodenum

Pathology of the Stomach and Duodenum comprehensively surveys gastric and duodenal disease, including clinical findings, pathophysiology, and epidemiology, and emphasizing diagnostic gross and microscopic pathology. Topics discussed include anomalies, gastritis, peptic ulceration, hyperplasias and benign epithelial tumors, carcinoma of the stomach and duodenum, carcinoid tumors, reactive and neoplastic lymphoid lesions, gastric smooth muscle and nerve sheath tumors, and miscellaneous lesions and rare conditions reflecting gastroduodenal participation in systemic disease.

Pheochromocytoma Producing Immunoreactive ACTH with Cushing's Syndrome

A 42-year-old female with clinical and endocrine indications of Cushings syndrome, as well as periodic hypertension and increased urinary catecholamines and their metabolites, benefitted from removal of a pheochromocytoma. Adrenocortical hyperplasia was present. Electron microscopy showed catecholamine-type granules in the tumor cells; in addition, immunoreactive ACTH, leu-enkephalin, somatostatin, and serotonin were identified. Such studies were performed for the first time in this unusual condition.

The reversible behavior of locally invasive endometrial carcinoma in a chromosomally mosaic (45,x/46,xr(x)) young woman treated with clomid®

A 22 year‐old phenotypic female with a 45,x/46,x, r(x) mosaic complement had anovulatory cycles, histologically normal ovaries, and atypical endometrial hyperplasia which, when clinically followed by repeated biopsies, was found to progress to locally invasive endometrial carcinoma. This was successfully managed by the induction of ovulation with Clomid®, which resulted in conversion of the endometrium to a normal secretory pattern for two subsequent years. Cancer 40:2957‐2966, 1977.

Neuroendocrine Carcinoma of Lung Associated with Bradycardia and Episodic Cardiac Asystole

A neuroendocrine carcinoma of the lung associated with bradycardia and episodic cardiac asystole is reported. Cardiac dysfunction may have been caused by a hormonal factor produced by a carcinoma developing in the pulmonary neuroepithelial bodies because the bradycardia and periods of asystole disappeared after pneumonectomy, only to return months later when pleural metastatic tumor developed. No neoplastic involvement of the heart was present. Implications of a cholinesterase isoenzyme involvement in the cardiac dysfunction are discussed.