Shieh Wb

Nosocomial Infections With Ceftazidime-Resistant Pseudomonas aeruginosa : Risk Factors and Outcome

Prospective studies were conducted for nosocomial Pseudomonas aeruginosa infections from February 1, 1994, to October 30, 1995. Of 97 P. aeruginosa isolates from 97 patients, 35 were resistant to ceftazidime. Logistic regression revealed previous cephalosporin or piperacillin use as independent risk factors for nosocomial ceftazidime-resistant P. aeruginosa infection. Pulsed-field gel electrophoresis revealed that four nosocomial ceftazidime-resistant P. aeruginosa infections were caused by cross-infection, probably through medical personnel.

Effect of nasal continuous positive airway pressure on methacholine-induced bronchoconstriction

Bronchial hyper-responsiveness is a cardinal feature of asthma. To determine whether nasal continuous positive airway pressure (NCPAP) influences airway smooth muscle in response to exogenous stimuli, we examined the effect of NCPAP on aerosolized methacholine-induced bronchoconstriction in 16 stable asthmatic patients. The dose-response curve for each subject was measured by a log transformation and linear regression analysis as well as a formula fitted to the data points to obtain values for a (slope) and b (position). The PD20FEV1 significantly increased in patients receiving 8 cmH2O of NCPAP by one doubling dose compared with that in patients using sham pressure. NCPAP shifted the dose-response curves to be flatter, deviated upwards and to the right. The coefficient a, indicating bronchial reactivity, was significantly lower in patients receiving NCPAP. The coefficient b, indicating the bronchial sensitive threshold, was higher after applying NCPAP. In contrast, coefficients a and b did not change in subjects with sham pressure. NCPAP also significantly enhanced the bronchodilator effect of inhaled salbutamol in response to methacholine-induced bronchoconstriction. In summary, we have shown that NCPAP therapy improves bronchial smooth reactivity with an increase in PD20FEV1 and a reduction in the bronchial reactivity and bronchial sensitivity. Therefore, NCPAP may provide an adjuvant therapy in patients with acute bronchial asthma.

Diabetes mellitus and hypertension based on the family history and 2-h postprandial blood sugar in the Ann-Lo district (Northern Taiwan)

From July 1988 to June 1990, we performed an epidemiological study on the prevalence of hypertension and diabetes mellitus (DM) in the Ann-Lo district, a suburban area of Northern Taiwan. One third of the population in the district was randomly sampled. A total of 9087 persons were screened with 67.4% participating. Following completion of the questionnaire blood pressure, 2 h postprandial blood sugar were determined. DM was defined when the blood sugar was over 200 mg/dl or the subject had a diabetic history. Hypertension was defined if the systolic blood pressure was over 160 mmHg or the diastolic blood pressure over 95 mmHg. Statistical comparisons were performed with a chi-square test, analysis of covariance, stepwise multiple regression and Pearson correlation matrix. In this study, the prevalence rate of DM was 2.6% and of hypertension was 6.4%. For those patients 40 years or older, the prevalence rate for DM was 8.0% and for hypertension was 19.7%. The prevalence of hypertension was 24.8% in overt diabetes and 5.2% in the normal subjects. Analysis of the data between risk factors of DM revealed that DM correlated with age, body mass index, hypertension, smoking, family history of DM and correlated negatively with education. Hypertension correlated with gender, alcohol intake and smoking, sugar level, age and body mass index. The prevalence rate of diabetes and hypertension were quite high in the district and this study pointed out the important risk factors for hypertension and DM in Taiwan.

Pulmonary actinomycosis appearing as a "ball-in-hole" on chest radiography and bronchoscopy.

A 40 year old diabetic man with pulmonary actinomycosis was admitted to hospital with recurrent haemoptysis. The chest radiograph showed an air meniscus in the left upper lobe, a rare presentation of pulmonary actinomycosis. Bronchoscopic examination revealed a mass in a cavity which has never been reported previously. He underwent lobectomy and the surgical specimen revealed sulphur granules, the typical pathological finding of actinomycosis, without evidence of fungal or mycobacterial infection.

Liver transplantation in Taiwan: the Chang Gung experience

SummaryBetween March 1984 and February 1991, six orthotopic liver transplantations were performed at the Chang Gung Memorial Hospital in Taiwan. The indications for transplantation were Wilsons disease (5 patients) and biliary atresia (1 patient). Donors and recipients were matched only for size and ABO blood group compatibility, and the recipient operations were performed without the use of a venovenous bypass. Arterial reconstruction was carried out by end-to-end hepatic artery anastomosis (4), thoracic aortic conduit (1), or interposition of an iliac artery graft (1), whereas biliary reconstruction was accomplished by a choledochocholedochostomy using a T-tube stent (4) or a choledochocholedochostomy using an external cholecystostomy without stenting (2). Biliary complications occurred in three patients, and all required additional surgery. The average duration of donor-liver cold ischemia, operating time, and blood loss during surgery were 7 h and 50 min (range, 4.5–9 h), 13.5 h (range, 11.8–17h), and 4,385 ml (range, 750–12,000 ml) respectively. The immunosuppressive regimens included a cyclosporinsteroid combination (n=2) and a triple-drug combination (n=4). All except one of the surviving patients experienced at least one rejection episode that was reversed by a methyl-prednisolone bolus and/or recycle. One patient developed a primary cytomegalovirus (CMV) infection that responded well to Ganciclovir treatment. Two of the patients died, one of injuries sustained in a traffic accident 3 years after transplantation, and the other of massive upper gastrointestinal bleeding. The overall survival value at 3 months was 83%, and the follow-up period ranged from 3 months to 7 years. All of the survivors have achieved complete rehabilitation and currently enjoy an excellent quality of life with normal liver function. Althought the present study involved a small number of cases, our results indicate that liver transplantation can be successfully achieved in a high proportion of patients with acceptable morbidity, mortality, and cost in an Asian setting. The extreme shortage of donor organs is currently the most important obstacle limiting the application of liver transplantation in Taiwan.

An unusual cause of dyspnea in a patient with cervical herpes zoster

Motor involvement in acute herpes zoster does occur,but is rare. Most causes of zoster paresis are due to the extension of the inflammation to the anterior horn and/or anterior motor roots. We report a female patient with an unusual diaphragmatic paralysis caused by cervical herpes zoster. The lesion, diagnosed by MRI, involved the anterior horn of the cervical spinal cord.

A 62-Year-Old Woman With Chronic Cough and Bronchospasm

62-year-old woman presented with chronic productive cough, intermittent wheezing, and shortness of breath over a 5-year period. She was a nonsmoker and had no history of environmental exposure to chemicals or dust. Her medical history was notable for nasopharyngeal cancer (NPC) treated with radiation therapy 26 years previously that resulted in mild dry mouth and hoarseness, nasal polyp, and chronic sinusitis. During the past 5 years, she underwent a series of examinations that revealed positive bronchodilator test and mild hyperinfl ation of lung parenchyma on chest radiograph. She received maintenance therapy with inhaled bronchodilator and corticosteroids, antihistaminics, and xanthine under the impression of chronic asthma and sinusitis, and antibiotics and oral corticosteroids during episodes of acute exacerbation. However, the clinical course fl uctuated, with deterioration of symptoms on climatic changes or following upper respiratory tract infection. Even though the patient denied being aware of any episodes of aspiration, she was hospitalized and treated as having aspiration pneumonia on four occasions. Yet, no advanced study was performed to evaluate her swallowing function. Tracing back her history, she experienced occasional choking episodes while drinking, but did not pay attention to them. Over the past year, her symptoms of productive

Comparative antimicrobial susceptibility of aerobic and facultative bacteria from community-acquired bacteremia to ertapenem in Taiwan

BackgroundErtapenem is a once-a-day carbapenem and has excellent activity against many gram-positive and gram-negative aerobic, facultative, and anaerobic bacteria. The susceptibility of isolates of community-acquired bacteremia to ertapenem has not been reported yet. The present study assesses the in vitro activity of ertapenem against aerobic and facultative bacterial pathogens isolated from patients with community-acquired bacteremia by determining and comparing the MICs of cefepime, cefoxitin, ceftazidime, ceftriaxone, ertapenem, piperacillin, piperacillin-tazobactam, ciprofloxacin, amikacin and gentamicin. The prevalence of extended broad spectrum β-lactamases (ESBL) producing strains of community-acquired bacteremia and their susceptibility to these antibiotics are investigated.MethodsAerobic and facultative bacteria isolated from blood obtained from hospitalized patients with community-acquired bacteremia within 48 hours of admission between August 1, 2004 and September 30, 2004 in Chang Gung Memorial Hospital at Keelung, Taiwan, were identified using standard procedures. Antimicrobial susceptibility was evaluated by Etest according to the standard guidelines provided by the manufacturer and document M100-S16 Performance Standards of the Clinical Laboratory of Standard Institute. Antimicrobial agents including cefepime, cefoxitin, ceftazidime, ceftriaxone, ertapenem, piperacillin, piperacillin-tazobactam, ciprofloxacin, amikacin and gentamicin were used against the bacterial isolates to test their MICs as determined by Etest. For Staphylococcus aureus isolates, MICs of oxacillin were also tested by Etest to differentiate oxacillin-sensitive and oxacillin-resistant S. aureus.ResultsErtapenem was highly active in vitro against many aerobic and facultative bacterial pathogens commonly recovered from patients with community-acquired bacteremia (128/159, 80.5 %). Ertapenem had more potent activity than ceftriaxone, piperacillin-tazobactam, or ciprofloxacin against oxacillin-susceptible S. aureus (17/17, 100%)and was more active than any of these agents against enterobacteriaceae (82/82, 100%).ConclusionBased on the microbiology pattern of community-acquired bacteremia, initial empiric treatment that requires coverage of a broad spectrum of both gram-negative and gram-positive aerobic bacteria, such as ertapenem, may be justified in moderately severe cases of community-acquired bacteremia in non-immunocompromised hosts.