Shigeaki Inoue

Survival and recurrence after low anterior resection and abdominoperineal resection for rectal cancer: the results of a long-term study with a review of the literature.

Morbidity, survival, and recurrence in 203 patients treated with curative low anterior resection (LAR) were compared with those in 100 patients treated with curative abdominoperineal resection (APR). The overall 5-year survival figures for the total number of, LAR and APR patients were 75.6±5.7%, 79.8±6.4% and 67.7±9.6%, respectively. The prognosis for cancers situated low enough in the rectum to involve the anal canal was poor even when managed by APR, as evidenced by a low survival at 5 years of 59.0±9.6% and a high pelvic recurrence rate of 34%. For all except these tumors, LAR proved at least equal to, or better than APR as a curative surgical method for middle and low rectal cancers, on the basis of 5-year survival being 79.8±6.4% vs 78.7±5.2%, operative mortality being 1.5% vs 1.0%, morbidity being 39.4% vs 59.0%, and the incidence of pelvic recurrence being 8.9% vs 13.5%. When deciding upon the most appropriate surgical procedure for rectal cancer, especially for middle or low rectal lesions, the patient should not simply be condemned to a permanent colostomy. Thus, we first attempt LAR for every lesion except those which are very advanced or those with anal canal involvement, if technically feasible and suitable for the individual patient.

Purification of placental anemia inducing factor (PAIF) and its clinical application by radioimmunoassay

SummaryHuman Placental Anemia Inducing Factor (PAIF) was purified from crude placental preparation called P-62, which had common biological and immunological natures with the same preparation from gastric juice, gastric tissues, serum and urine of patients with malignant neoplasma, especially gastric cancer1-4). The obtained PAIF was homogeneous on polyacrylamide gel electrophoresis and gave a specific band in the region of γ-A and/or γ-M globulin on immunoelectrophoresis.The purified PAIF induced anemia in rabbits by intravenous administration at a dose of 2.7 Μg/Kg of body weight. No cross antigenicity of PAIF was observed with α-Fetoprotein, HBs antigen and CEA.Serum AIF of patients was measured using PAIF as a standard by radioimmunoassay. AIF levels in sera of patients with malignant neoplasma were significant high compared with those of control groups.