Shigeaki Kaga
University of Yamanashi
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Publication
Featured researches published by Shigeaki Kaga.
Molecular and Cellular Biochemistry | 2004
Shoji Fukuda; Shinpei Yoshii; Shigeaki Kaga; Masahiko Matsumoto; Kiyotaka Kugiyama; Nilanjana Maulik
In the Western World ischemic coronary disease is the leading cause of morbidity and mortality. Therapeutic approaches mostly aim to restore flow to a localized segment by angioplasty or bypass surgery. Therapeutic angiogenesis and or arteriogenesis describes a strategy where blood vessel formation is induced for the purposes of treating and/or preventing ischemic disease. At present, at least 17 clinical trials of myocardial angiogenesis have been presented involving over 900 patients. Therapeutic angiogenesis makes use of the administration of angiogenic growth factor protein or gene to promote the development of endogenous collateral vessels in ischemic myocardium. Most recently, interest has grown in the potential angiogenesis effects of cell therapy—such as autologous bone marrow cells or cultured stem cells—and there are now several groups initiating phase I/II trials in this area. (Mol Cell Biochem 264: 143–149, 2004)
The Japanese Journal of Thoracic and Cardiovascular Surgery | 2000
Hiroshi Osawa; Shinpei Yoshii; Shigeru Hosaka; Shoji Suzuki; Shigeaki Kaga; Yusuke Tada
A 3-year-old boy suffered severe heart failure 2 months after ventricular septal defect repair. The cardiothoracic ratio was 67% and the ejection fraction 13%. Echocardiography showed a dilated left ventricle and thin myocardium. After thorough study, we made a diagnosis of dilated cardiomyopathy. Because conventional therapy was unsuccessful, we conducted partial left ventriculectomy with Alfieri repair of the mitral valve. The postoperative cardiothoracic ratio was 57% at 1 year of follow-up and the ejection fraction 40%. The New York Heart Association functional class improved from IV to I. In conclusion, the role of partial left ventriculectomy is both as a bridge to transplantation and as a definitive repair in dilated cardiomyopathy during childhood.
The Journal of Thoracic and Cardiovascular Surgery | 1999
Shinpei Yoshii; Shigeru Hosaka; Wataru Takahashi; Hiroshi Amano; Abraham S; Shigeaki Kaga; Yusuke Tada; Hisashi Sugiyama; Jun Yanai
being living autogenous tissue. Hence the potential for growth exists when the pulmonary autograft is used in the aortic position, and that is the reason the Ross operation is considered ideal for aortic valve replacements in infants and children. However, the potential for growth is lost when the pulmonary autograft is used in the mitral position because it has to be housed within the Dacron tube. On the other hand, inasmuch as the autograft is lying in the left atrium as a top hat, a partial or total preservation of the mitral valve apparatus is feasible, as was done in our patient. The autograft is a living autogenous tissue, fully flexible, and it cannot obstruct the left ventricular outflow tract because of its position inside the left atrium (Figs I and 2). The improved clinical condition of our patient, freedom from anticoagulation, absence of thromboembolism, and the maintained excellent performance of the pulmonary autograft in the mitral position 6 years later cautiously support this procedure as a viable alternative in specific clinical situations requiring replacement of the mitral valve. However, a larger The Journal of Thoracic and Cardiovascular Surgery March 1999
Asian Cardiovascular and Thoracic Annals | 2009
Koki Takizawa; Shoji Suzuki; Yoshihiro Honda; Shigeaki Kaga; Hidenori Inoue; Masahiko Matsumoto
We report a long-term survivor with Uhls anomaly who underwent one and a half ventricle repair combined with a partial right ventriculectomy in infancy, followed by successful total cavopulmonary conversion with right ventricular exclusion 5 years later. The combination of total cavopulmonary connection and right ventricular exclusion could be the optimal surgical option for a critically ill infant with Uhls anomaly.
Artificial Organs | 2008
Shunya Shindo; Shinya Motohashi; Masatake Katsu; Shigeaki Kaga; Hidenori Inoue; Masahiko Matsumoto
This prospective study was conducted to compare inflammatory responses between patients receiving coated and uncoated vascular prostheses, and to examine their effect on length of stay and cost of patients undergoing abdominal aortic aneurysmectomy. Patients undergoing elective vascular reconstruction of an abdominal aortic aneurysm were assigned randomly to coated-graft or uncoated-graft groups (n = 20, for each group). Interleukin (IL)-6, granulocyte elastase, white blood cell count, C-reactive protein (CRP), and body temperature (BT) were prospectively recorded preoperatively and on postoperative days (PODs) 1, 3, 7, and 14. In-hospital stay and hospitalized costs were also analyzed. IL-6 and CRP concentrations in the coated-graft group were higher than those in the uncoated-graft group (P = 0.01 and 0.05). BT was more frequently elevated >37 degrees C at POD 14 in the coated-graft group than in the uncoated-graft group (P =0.03). Discharge was delayed, and overall hospitalization cost was higher in the coated-graft group than in the uncoated group (17.6 vs. 13.5 days, and 2 010 000 vs. 1 780 000 yen, P = 0.006 and P = 0.002, respectively). Coated vascular prosthesis demonstrated more profound inflammatory reaction than noncoated prosthesis, postoperatively.
Surgery Today | 2007
Shunya Shindo; Shinya Motohashi; Masatake Katsu; Shigeaki Kaga; Hidenori Inoue; Masahiko Matsumoto; Koji Kono; Hideki Fujii; Masayuki Takeda
Retroperitoneal tumors and other abdominal malignancies invading the inferior vena cava can be treated surgically when no metastases are present. We resected four retroperitoneal tumors, two renal cell carcinomas, and one gastrointestinal stromal tumor with a concomitant caval resection. Although meticulous care is required when manipulating the major vessels, long-term survival with an improvement in the quality of life was achieved. These cases are described, with particular focus on the management of the major vessels.
The Annals of Thoracic Surgery | 2008
Shoji Suzuki; Hiroshi Watanabe; Shinpei Yoshii; Shigeaki Kaga; Yoshihiro Honda; Natsuya Ishikawa; Masahiko Matsumoto
We applied a new implanting technique for an implantable cardioverter defibrillator (ICD) in a 4-month-old girl with repeated ventricular fibrillation (Vf) due to long QT syndrome. This technique consisted of placement of an oval patch lead on the outer surface of the pericardium in the left pleural cavity. This was useful in preventing the complications of the conventional epicardial patch leads (ie, crinkling of the lead and constrictive pericarditis). This patch should be contemplated as an alternative option for implanting ICD in infants.
Abdominal Imaging | 2007
Shunya Shindo; Shinya Motohashi; Shigeaki Kaga; Hidenori Inoue; Masahiko Matsumoto; Hiroo Shindo
Paroxysmal nocturnal hemoglobinuria is a rare acquired autoimmune disease, and is frequently associated with venous thrombosis. A patient who developed thrombotic occlusion of the inferior vena cava is described. Treatment with heparin and urokinase, followed by oral anticoagulant, was effective in resolving abdominal symptoms. The venous thrombosis resolved completely, but the patient died during treatment of aplastic anemia.
Annals of Vascular Diseases | 2013
Kenji Sakakibara; Shunya Shindo; Masahiko Matsumoto; Yukiyo Yoshida; Mitsuhiro Kimura; Yoshihiro Honda; Kentaro Kamiya; Masatake Katsu; Shigeaki Kaga; Shoji Suzuki
We herein report the case of a splenic artery aneurysm with a hepatosplenomesenteric trunk that presented in a pregnant woman. Catheter embolization was not performed due to the wide neck of the aneurysm and its close location to the trunk indicates a high risk of mesenteric trunk thrombosis. We instead performed surgical resection of the aneurysm after successful delivery of the infant by Caesarian section. The splenic artery was reconstructed by side-to-end anastomosis with the common hepatic artery.
Heart and Vessels | 2018
Keiichi Koizumi; Minako Hoshiai; Takeshi Moriguchi; Takako Toda; Nobuyuki Katsumata; Hiroaki Kise; Yohei Hasebe; Yousuke Kouno; Junko Goto; Norikazu Harii; Kenichi Matsuda; Shigeaki Kaga; Shoji Suzuki; Kanji Sugita
In original publication of the article, some of the co-author’s names were not included. The correct author group is published in this article.