Shigeki Nishimoto
Kobe University
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Featured researches published by Shigeki Nishimoto.
Journal of Molecular Medicine | 1984
Munetada Oimomi; Shigeki Nishimoto; Yoshiaki Kitamura; Shinichiro Matsumoto; Hiroshi Hatanaka; Kazuo Ishikawa; Shigeaki Baba
SummaryFructose-lysine, which is formed by binding glucose to lysine, is degraded on acid hydrolysis into furosine. Furosine was determined by high-performance liquid chromatography according to the method of Schleicher et al. Furosine values were significantly higher in diabetic patients than in healthy subjects, and significantly correlated with haemoglobin A1 (HbA1) values. These results suggest that furosine, like HbA1, may become an indicator of long-term blood glucose control in diabetic patients and be useful in investigating diabetic complications on the level of tissue.
Diabetes Research and Clinical Practice | 1985
Munetada Oimomi; Shigeki Nishimoto; Shinichiro Matsumoto; Hiroshi Hatanaka; Kazuo Ishikawa; Shigeaki Baba
The periflux blood flow (PBF) response pattern in the fingertips determined with a periflux laser Doppler flowmeter was analyzed in a standing test in which the subject was instructed to stand up from the sitting position and in Valsalvas maneuver in which respiration was held for 10 s at the maximum inspiration, and indicators such as reaction time (RT), orthostatic dysreaction rate (ODR) and PBF decreasing velocity (PDV) were established for determining autonomic abnormality. RT and ODR were significantly correlated with the change in blood pressure and pulse rate, respectively, in the standing test, and PDV was significantly correlated with beat-to-beat variation. Abnormalities were found in about half of the diabetics in the standing test and Valsalvas maneuver. These results suggested that the analysis of PBF changes in the standing and Valsalvas tests may be an easy and useful approach for clinical examination of the autonomic nervous system.
Archives of Gerontology and Geriatrics | 1989
Munetada Oimomi; Naoya Igaki; Fumihiko Hata; Yoshiaki Kitamura; Shigeki Nishimoto; Shigeaki Baba; Sakan Maeda
The extent of glycation in pieces of human aorta was estimated by determining the content of furosine, which is derived from fructose-lysine through acid hydrolysis. Glycation of human aorta was found to increase with advancing age. A significant positive correlation was found between the degree of atherosclerosis and the furosine level in the aorta in subjects over 60 years of age. Furthermore, the furosine level in the aortae of diabetic patients was significantly higher than that in normal subjects of the same age. These results suggest not only that glycation in the aorta may increase with aging and with the development of arteriosclerosis, but also that diabetes may be related as well to premature aging as to arteriosclerosis.
Diabetes Research and Clinical Practice | 1985
Munetada Oimomi; Shigeki Nishimoto; Shinichiro Matsumoto; Hiroshi Hatanaka; Kazuo Ishikawa; Shigeaki Baba
In order to get an accurately specific determination of glycosylated hemoglobin (GHb-f), the furosine assay method, which can detect epsilon-amino-lysine-bound glucose, was investigated. A good correlation was found between GHb-f values obtained by this method and HbA1 values by conventional ion exchange column chromatography. It was, therefore, considered that this technique would be a new useful method for determining glycosylated hemoglobin.
The Journals of Gerontology | 1986
Munetada Oimomi; Yoshiaki Kitamura; Shigeki Nishimoto; Shinichiro Matsumoto; Hiroshi Hatanaka; Shigeaki Baba
Clinica Chimica Acta | 1989
Shigeki Nishimoto; Munetada Oimomi; Shigeaki Baba
Japanese Journal of Nephrology | 1986
Munetada Oimomi; Shigeki Nishimoto; Shinichiro Matsumoto; Hiroshi Hatanaka; Kazuo Ishikawa; Tomihiro Kawasaki; Yukio Yoshimura; Shigeaki Baba
Japanese Journal of Clinical Chemistry | 1988
Munetada Oimomi; Fumihiko Hata; Naoya Igaki; Shogo Masuta; Tsuneo Nakamichi; Yuichiro Maeda; Shigeki Nishimoto; Shinichiro Matsumoto; Shigeaki Baba
Japanese Journal of Clinical Chemistry | 1988
Munetada Oimomi; Shogo Masuta; Naoya Igaki; Tsuneo Nakamichi; Yuichiro Maeda; Fumihiko Hata; Yoshiaki Kitamura; Shigeki Nishimoto; Shinichiro Matsumoto; Shigeaki Baba
The journal of Japan Atherosclerosis Society | 1989
Shigeki Nishimoto; Tsuneo Nakamichi; Fumihiko Hata; Yoshiaki Kitamura; Munetada Oimomi; Shigeaki Baba; Sakan Maeda