Shigeki Tamura
Astellas Pharma
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Shigeki Tamura.
International Journal of Pharmaceutics | 1994
Takeshi Hata; Yasuo Shimazaki; Akira Kagayama; Shigeki Tamura; Satoshi Ueda
Abstract FK409, a new vasolidator, was applied to a time-controlled explosion system (TES). after oral administration of the TES with a lag time of 3 h to conscious dogs, both the blood FK409 level and blood pressure were monitored. FK409 appeared in the blood at 3 h and the maximum level was attained at 5 h according to the in vitro release profile. In response to the blood concentration profile of FK409, the blood pressure predominantly decreased after 3 h and minimized around 5 h. A human bioavailability study was also performed, using the TES with a lag time of 3 h. The in vivo lag time for the appearance of drug in the blood was consistent with the in vitro lag time for drug release. Compared with a rapid release formulation, the extent of FK409 absorbed did not decrease and the blood concentration profile was completely separated. Furthermore, the blood concentration profile was not influenced by food intake. These results suggest that the novel drug delivery system, the TES, has potential for use as a preparation of FK409 with prolonged activity.
Journal of Pharmaceutical Sciences | 2002
Shigeki Tamura; Atsuo Ohike; Rinta Ibuki; Gordon L. Amidon; Shinji Yamashita
Journal of Pharmacology and Experimental Therapeutics | 2003
Shigeki Tamura; Yuji Tokunaga; Rinta Ibuki; Gordon L. Amidon; Hitoshi Sezaki; Shinji Yamashita
Archive | 1999
Eiji Hashimoto; Takeo Chayamachi Hirose; Rinta Ibuki; Toshio Ideno; Yukihiro Nomura; Takashi Saitoh; Fumio Shimojo; Shigeki Tamura; Satoshi Ueda; Kazunari Yamashita
Archive | 2003
Kazunari Yamashita; Eiji Hashimoto; Yukihiro Nomura; Fumio Shimojo; Shigeki Tamura; Takeo Hirose; Satoshi Ueda; Takashi Saitoh; Rinta Ibuki; Toshio Ideno
Drug Metabolism and Pharmacokinetics | 2004
Shigeki Tamura; Atsuo Ohike; Yuji Tokunaga; Rinta Ibuki; Gordon L. Amidon; Hitoshi Sezaki; Shinji Yamashita
Archive | 1999
Takashi Higo; Rinta Ibuki; Shigeo Nakanishi; Shigeki Tamura; Toshihiko Toyoda; 茂雄 中西; リン太 伊吹; 繁樹 田村; 孝志 肥後; 俊彦 豊田
Archive | 2004
Shigeki Tamura; L. Amidon; Shinji Yamashita
Archive | 1999
Kazunari Yamashita; Eiji Hashimoto; Yukihiro Nomura; Fumio Shimojo; Shigeki Tamura; Takeo Hirose; Satoshi Ueda; Takashi Saitoh; Rinta Ibuki; Toshio Ideno
Archive | 1999
Kazunari Yamashita; Eiji Hashimoto; Yukihiro Nomura; Fumio Shimojo; Shigeki Tamura; Takeo Hirose; Satoshi Ueda; Takashi Saitoh; Rinta Ibuki; Toshio Ideno