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Shigeo Katsumura

Kwansei Gakuin University

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Publication

Featured researches published by Shigeo Katsumura.

Bioscience, Biotechnology, and Biochemistry | 2007

Kinetics of the ceramide kinase inhibitor K1, a suppressor of mast-cell activation.

Hirotaka Kumada; Susumu Mitsutake; Yuichi Inagaki; Shino Mitsunaga; Hiroshi Tsuchikawa; Shigeo Katsumura; Yasuyuki Igarashi

In a previous study, we synthesized a novel inhibitor of ceramide kinase, K1. In this study, we determined that inhibition by K1 is non-competitive and that four intact six-membered rings are important to the inhibitory activity. Furthermore, we identified an effective in vivo concentration for K1, at which it did not influence any cellular lipid synthesis other than that of ceramide 1-phosphate (C1P) using RBL-2H3 cells, and found that K1 suppressed the activation of mast cells.

Journal of Organic Chemistry | 2004

Development of Highly Stereoselective Asymmetric 6π-Azaelectrocyclization of Conformationally Flexible Linear 1-Azatrienes. From Determination of Multifunctional Chiral Amines, 7-Alkyl cis-1-Amino-2-indanols, to Application as a New Synthetic Strategy: Formal Synthesis of 20-Epiuleine

Katsunori Tanaka; Toyoharu Kobayashi; Hajime Mori; Shigeo Katsumura

Organic Letters | 2006

Versatile Synthetic Method for Sphingolipids and Functionalized Sphingosine Derivatives via Olefin Cross Metathesis

Tetsuya Yamamoto; Hiroko Hasegawa; Toshikazu Hakogi; Shigeo Katsumura

Journal of Organic Chemistry | 2004

Stereocontrolled Total Synthesis of a Polyfunctional Carotenoid, Peridinin

Noriyuki Furuichi; Hirokazu Hara; Takashi Osaki; Masayuki Nakano; Hajime Mori; Shigeo Katsumura

Organic Letters | 2006

Development of a one-pot asymmetric azaelectrocyclization protocol: synthesis of chiral 2,4-disubstituted 1,2,5,6-tetrahydropyridines.

Toyoharu Kobayashi; Miyuki Nakashima; Toshikazu Hakogi; and Katsunori Tanaka; Shigeo Katsumura

Organic Letters | 2006

Synthesis of 2,4,6-Trisubstituted Chiral Piperidines and (−)-Dendroprimine by One-Pot Asymmetric Azaelectrocyclization Protocol

Toyoharu Kobayashi; Futoshi Hasegawa; and Katsunori Tanaka; Shigeo Katsumura

Biochimica et Biophysica Acta | 2005

Suppression of mast cell degranulation by a novel ceramide kinase inhibitor, the F-12509A olefin isomer K1

Jin-Wook Kim; Yuichi Inagaki; Susumu Mitsutake; Nobuhiro Maezawa; Shigeo Katsumura; Yeon-Woo Ryu; Chang-Seo Park; Masaru Taniguchi; Yasuyuki Igarashi

Biochemical and Biophysical Research Communications | 2004

Bisphenol A, an environmental endocrine-disrupting chemical, inhibits hypoxic response via degradation of hypoxia-inducible factor 1α (HIF-1α): structural requirement of bisphenol A for degradation of HIF-1α ☆

Tomoko Kubo; Nobuhiro Maezawa; Mayuko Osada; Shigeo Katsumura; Yoshihiko Funae; Susumu Imaoka

Organic and Biomolecular Chemistry | 2005

Total synthesis of paracentrone, C31-allenic apo-carotenoid.

Yusuke Murakami; Masayuki Nakano; Takuya Shimofusa; Noriyuki Furuichi; Shigeo Katsumura

Tetrahedron Letters | 2006

Synthesis of sphingomyelin difluoromethylene analogue

Toshikazu Hakogi; Tetsuya Yamamoto; Shinobu Fujii; Kiyoshi Ikeda; Shigeo Katsumura

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Toshikazu Hakogi

Kwansei Gakuin University

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Toyoharu Kobayashi

Tokyo University of Pharmacy and Life Sciences

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Nobuhiro Maezawa

Kwansei Gakuin University

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Hajime Mori

Kwansei Gakuin University

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Hiroshi Tsuchikawa

Kwansei Gakuin University

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Noriyuki Furuichi

Kwansei Gakuin University

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Tetsuya Yamamoto

Kwansei Gakuin University

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Hiroko Hasegawa

Kwansei Gakuin University

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Kiyoshi Ikeda

Osaka University of Pharmaceutical Sciences

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Masayuki Nakano

Kwansei Gakuin University

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