Shin-Tsu Chang

Effects of piroxicam-beta-cyclodextrin sachets on abnormal postural sway in patients with chronic low back pain

Backgrounds:  The clinical effects of piroxicam‐beta‐cyclodextrin (PBC) in sachet form have been surveyed in patients with osteoarthritic or acute pain in western countries, but scarcely studied in those with chronic low back pain (LBP), and never investigated in the field of postural sway. The aim of this study was to evaluate the clinical effects of PBC in sachet form prescribed in patients with chronic backache in local Asian when compared with those of plain piroxicam.

Short-term effects of self-massage combined with home exercise on pain, daily activity, and autonomic function in patients with myofascial pain dysfunction syndrome.

[Purpose] The aim of the present was to investigate the short-term effects of a program combining self-massage and home exercise for patients with myofascial pain dysfunction syndrome (MPDS). [Subjects and Methods] In this retrospective study, 63 patients were allocated to the experimental (n = 32) and control (n = 31) groups. Both groups received 6 sessions of treatment with physical modalities over the course of two weeks. The experimental group completed an additional program with a combination of self-massage and home exercise. The outcome measurements included a pain scale, pressure pain threshold (PPT), neck disability index (NDI), patient-specific functional scales (PSFS), and heart rate variability (HRV). The interactions between the groups and over time were analyzed using two-way repeated measures ANOVA. [Results] Only the experimental group demonstrated significant improvements in the pain scale with varying conditions. The PPTs of the trigger points increased significantly in the experimental group, and significant functional improvements in NDI and PSFS were observed in the same group. There were significant increases in high-frequency HRV and high-frequency % in the experimental group. [Conclusion] Treatment with physical modalities plus combination of self-massage and home exercise is more effective than the physical modalities treatment alone.

Hemichorea associated with gabapentin therapy with hypoperfusion in contralateral basal ganglion - a case of a paraplegic patient with neuropathic pain.

Functional imaging in patients with movement disorders has suggested abnormalities of regional cerebral blood flow (rCBF). We describe a patient with thoracic cord lesion with subsequent severe neuropathic pain. Right hemichorea developed and was related to adjunctive therapy with gabapentin. The patient’s hemichorea decreased gradually after cessation of gabapentin. The study of rCBF revealed hypoperfusion in the contralateral basal ganglia compared with the previous study of rCBF. Our patient is the first patient with neuropathic pain, treated with gabapentin who developed hemichorea, in the absence of brain lesions. Imaging studies of rCBF showed a perfusion defect in the contralateral basal ganglion.

Concurrent measurement of isokinetic muscle strength of the trunk, knees, and ankles in patients with lumbar disc herniation with sciatica.

Study Design. A cross-sectional study comparing normal subjects and patients with lumbar disc herniation (LDH) with sciatica. Objective. To simultaneously measure the isokinetic muscle strength of the trunk, knees, and ankles in both groups. Summary of Background Data. Coordination between the trunk and lower extremity muscles is important for normal physical activity. Reduced trunk and knee muscle strength have been reported in patients with lower level LDH; however, ankle performance in these patients is still unknown. Methods. We recruited 43 normal subjects as controls and 33 patients with lower level LDH with sciatica. The isokinetic strength of the trunk, knees, and ankles was measured at 2 velocities in random order: 60°/s and 120°/s, and 60°/s and 180°/s for trunk and ankle strength and for knee strength, respectively. Results. The isokinetic trunk strength was significantly lower in the LDH group irrespective of test modes or velocity. Despite unilateral sciatica or test modes and velocity, the unilateral knee strength was significantly lower in the LDH group than that in the control group. Knee extension torque was also found to be significantly lower in the limbs with sciatica than in those without sciatica at the testing velocity of 180°/s (80.25 ± 24.88 vs. 95.42 ± 26.29 Nm, P < 0.05). Irrespective of unilateral sciatica or test velocity, ankle plantar flexion torque revealed to be significantly lower in the LDH group than the control group; however, dorsiflexion torque was not different. Significant correlations were demonstrated among the total muscle strength of the trunk, knees, and ankles in both groups. Conclusion. Besides the lower trunk strength, concurrent lower unilateral knee and ankle plantar flexion but not dorsiflexion strength was demonstrated in the LDH subjects with unilateral sciatica, regardless of its location. As compared to the limbs without sciatica, an additional 14% reduction of knee extension torque at 180°/s was found in the limbs with sciatica in the LDH patients.

Cerebellar diaschisis and contralateral thalamus hyperperfusion in a stroke patient with complex regional pain syndrome.

We present a right-hemispheric stroke patient with complex regional pain syndrome (CRPS). The regional cerebral blow flow (rCBF) as determined using single photon emission computed tomography (SPECT) showed contralateral increase of tracer uptake in the left thalamus accompanied by crossed cerebellar diaschisis (CCD) in the left cerebellum. After rehabilitation, the CRPS in the right upper extremity recovered, although hemiplegia persisted on the left limbs. The rCBF determined a second time using SPECT showed that uptake was normal in the bilateral thalami, basal ganglia and bilateral cerebella. At a 6-month follow-up, the CRPS had not recurred. Our findings show that analysis of rCBF by SPECT is useful for the clinical evaluation and follow-up of CRPS. To the best of our knowledge, this is the first reported case with this particular pattern of symptoms amd symptom resolution.

Resolution of Intractable Hiccups after Near-Infrared Irradiation of Relevant Acupoints

Background:Intractable hiccups are occasionally encountered in the presence of stroke but are usually difficult to manage. Methods:We describe two stroke patients with intractable hiccups that were refractory to pharmacological treatment but were well resolved by application to relevant acupoints with the modality linear polarized near-infrared ray equipment on PC 6 (Nei Guan), ST 36 (Zu San Li), and DU 9 (Chih Yang), which are the empirical acupoints aimed at regulating gastrointestinal mobility and function of the thoracic organ. Results:The first patient who received the treatment for only one time came out with a dramatic termination of intractable hiccups 3 hours later and with no recurrence thereafter. We applied the same treatment on the second patient once a day for 8 consecutive days, which led to progressive amelioration of intractable hiccups. Conclusions:This is the first report about the complete resolution of intractable hiccups due to stroke using near-infrared irradiation to acupoints, rather than using conventional pharmacologic therapy, traditional acupuncture, or moxibustion. Consequently, these findings suggest that linear polarized near-infrared ray irradiation, with its noninvasive properties, might be an alternative treatment for intractable hiccups after stroke.

The Predictor of Mortality within Six-Months in Patients with Spontaneous Cerebellar Hemorrhage: A Retrospective Study

Background and Purpose The mortality rate of cerebellar hemorrhage (CH) is generally higher than other types of intracranial hemorrhage. Recently, the increased survey rate of CH has come from improved clinical imaging and earlier surgical intervention. Hence, the predictors of intermittent- (1 to 6 months) and long-term (> 6months) mortality are clinically practical use for educational and therapeutic decisions. Unfortunately, the factors predictive mortality within six-month had not yet been systematically investigated. Methods Seventy-two patients with acute spontaneous CH were retrospectively analyzed. The patients were divided into the six-month mortality group (n = 21, died within 6 months after CH onset) and survival group (n = 51, survived beyond 6 months). The independent predictors of six-month mortality were investigated by multivariate Cox proportional hazards regression. Results The radiological brainstem compression (hazard ratios = 23.5; p < 0.001) was independent predictor of mortality within six-month after CH onset. The median onset time of six-month mortality was 5 days in patients with brainstem compression (p < 0.001) and the hazard ratios for the onset time was 13.1 compared with those without brainstem compression (95% CI, 4.7 to 36.3, p < 0.001). Conclusions We report the first study that radiological brainstem compression predicted the mortality within six-month after onset of CH. Patients with radiological brainstem compression were about 23 times more likely to die within 6 months after CH than those without radiological brainstem compression.

Amelioration of pathological yawning after tracheostomy in a patient with locked-in syndrome.

A 66-year-old female with a past history of hypertension, who initially presented with four limbs weakness for a duration of 3 h, poor visual acuity, ataxia and slurred speech at ER and progressed to drowsiness, tetraplegia with episodes of unjustified excessive and repetitive yawning and acute respiratory failure within few hours. On admission, the patient was drowsy and showed a positive doll s eye sign and positive gag reflex. Her uvula and tongue deviated to the left and weakness of facial muscle caused drooling. The right upper and lower extremity strength were rated 3+/5 and 2+/5 separately. The left upper and lower extremity strength were rated 2+/5 and 0+/5 respectively. Deep tendon reflexes were enhanced and bilateral Babinski signs were present. A brain magnetic resonance imaging (MRI) scan showed an infarct in most parts of the pons and another small lesion in right medial occipital lobe appearing as increased signal intensity on DWI with corresponding low ADC. MRI showed total occlusion of the middle and distal thirds of basilar artery. Besides, the left posterior cerebral artery arose from the left internal carotid artery with focal stenosis at its proximal portion and there was an aneurysm about 3 mm in size located at the anterior communicating artery (Fig. 1). The patient developed acute respiratory failure and progress to flaccid tetraplegia several hours after admission. The frequency of excessive yawning persisted despite adequate sleep at night. An endotracheal tube was inserted as a prerequisite of subsequent ventilatory support. Several days later, she still had limitations

Brown-Sèquard syndrome caused by type III odontoid fracture: a case report and review of the literature.

Study Design. Case report. Objective. To present the second case of Brown-Sèquard syndrome (BSS) produced by type III odontoid fracture managed by conservative treatment. Summary of Background Data. The occurrence of BSS due to odontoid fracture is scarce. So far 6 cases have been reported, and only 1 is produced by type III odontoid fracture. The possible pathophysiology, clinical course and treatment outcome have been rarely discussed. Methods. A 39-year-old man presented with weakness of his left arm and leg, mild neck pain, and impaired proprioceptive and light touch sensations below the left C2 dermatome. There were decreased pain and temperature sensations below the right C4 dermatome too. Computerized tomography showed odontoid type III fracture with posterior displacement at that level. Magnetic resonance imaging presented focal hyperintensity around the C2 vertebral level. High dose of prednisolone, close reduction with Gardner-Wells tong skull traction, following external stabilization by Halo-Vest and rehabilitation therapy were applied. Results. Complete resolution of neck pain and significant improvement of motor and sensory functions, i.e., light touch and proprioception, were shown 2 months after spinal injury. Impaired temperature discrimination persisted, however. Conclusion. BSS is rarely caused by type III odontoid fracture and this is the second report. Conservative intervention is advantageous for both type III odontoid fracture and BSS which is consistent with previous results.

Efficacy of near-infrared irradiation on intractable hiccup in custom-set acupoints: Evidence-based analysis of treatment outcome and associated factors

Objective. The condition intractable hiccup (IH) is generally an incapacitating disorder indicating neurologic or non-neurologic disorders. Linearly polarized, near-infrared irradiation (SL) is shown to be effective in the treatment of IH where it is applied on custom-set acupoints. The aim of this study was to investigate the treatment efficacy of IH by SL on the acupoints and to survey the relationship between IH and comorbid-related factors. Material and methods. A total of 35 patients with IH were enrolled prospectively and divided into central and non-central groups. All patients received SL using an SG-type lens unit on the relevant acupoints and were followed-up for up to 6 months for efficacy of the novel therapy. Results. There was no significant difference between patients with IH produced by central or non-central origins (p=0.7105) regarding the therapeutic effect of SL; however, the effects of age, bed-shaking, gun-waving motion and nasogastric (NG)-tube placement were significant. The severity index of IH was analyzed and found to be associated with the seasons. For those patients with elevated levels of aspartate aminotransferase (ASAT) after therapy, it took a significantly shorter (p=0.0029) period of time to treat IH with this novel therapy (p=0.0029). Thirty-four patients had complete resolution of IH within a few days of beginning SL, with partial resolution in 1 patient only. Conclusions. Without potential side effects, SL on custom-set acupoints could be a complementary therapy for patients with IH regardless of central or non-central origins.