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Shinji Kudoh

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Publication

Featured researches published by Shinji Kudoh.

Bioorganic & Medicinal Chemistry Letters | 1997

Synthesis and antirheumatic activity of novel tetrahydro-6-quinolineacetic acid derivatives

Yasushi Kohno; Katsuya Awano; Mitsutomo Miyashita; Takayoshi Ishizaki; Kazuhiko Kuriyama; Yasuhiko Sakoe; Shinji Kudoh; Koji Saito; Eisuke Kojima

Abstract A study of the structural optimization of tetrahydroquinoline-6-acetic acid and the development of a novel DMARD with prompt action are detailed. ( S )-(+)-8-Chloro-1,2,3,4-tetrahydro-2-trifluoromethyl-6-quinolineacetic acid (IRA-378) exhibits the effect against both acute and chronic inflammations. It also has suppressive effects of bone destruction in adjuvant arthritis and Ca release from bones in vitro .

Bioorganic & Medicinal Chemistry Letters | 1997

Synthesis and antirheumatic activity of novel tetrahydroquinoline-8-carboxylic acid derivatives

Yasushi Kohno; Katsuya Awano; Mitsutomo Miyashita; Shizuyoshi Fujimori; Kazuhiko Kuriyama; Yasuhiko Sakoe; Shinji Kudoh; Koji Saito; Eisuke Kojima

Abstract A study of the modification of N -alkylanthranilic acids to develop novel DMARDs is detailed. 1,2,3,4-Tetrahydroquinoline-8-carboxylic acid derivatives were found to exhibit a therapeutic effect on adjuvant arthritis and a suppressive effect on bone destruction.

Archive | 1992

Novel cyclic aminophenylacetic acid derivative, production thereof, and immune response modulator containing the same as active ingredient

Yasushi Kohno; Katsuya Awano; Takayoshi Ishizaki; Eisuke Kojima; Shinji Kudoh; Yasuhiko Sakoe; Koji Saito

炎症 : 日本炎症学会雑誌 : Japanese journal of inflammation | 1996

Suppressive effect of a novel immunomodulator, IRA-378, on adjuvant arthritis in rats

Eisuke Kojima; Koji Saito; Yasuhiko Sakoe; Kazuhiko Kuriyama; Shinji Kudoh; Seigo Suzue

Archive | 1999

CYCLIC AMINOPHENYLACETIC ACID DERIVATIVES WITH IMMUNOMODULATING ACTION, PROCESSES FOR PREPARATION AND SYNTHESIS INTERMEDIATES THEREOF

Yasushi Kohno; Katsuya Awano; Takayoshi Ishizaki; Eisuke Kojima; Shinji Kudoh; Yasuhiko Sakoe; Koji Saito

Archive | 1997

CYCLIC DERIVATIVES OF AMINOPHENYLACETIC ACID, PROCESSES AND INTERMEDIATES OF THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS BASED THEREON

Yasushi Kohno; Katsuya Awano; Takayoshi Ishizaki; Eisuke Kojima; Shinji Kudoh; Yasuhiko Sakoe; Koji Saito

Archive | 1993

CYCLIC DERIVATIVES OF AMINOPHENYLACETIC ACID, PROCESS OF THEIR PREPARATION AND MEDICAMENTS BASED THEREON

Yasushi Kohno; Katsuya Awano; Takayoshi Ishizaki; Eisuke Kojima; Shinji Kudoh; Yasuhiko Sakoe; Koji Saito

Archive | 1992

Process for the preparation of pharmacologically active 1,2,3,4-tetrahydroquinoline-6-acetic acid derivatives and quinoline derivatives for use as an intermediate in

Yasushi Kohno; Katsuya Awano; Takayoshi Ishizaki; Eisuke Kojima; Shinji Kudoh; Yasuhiko Sakoe; Koji Saito

Archive | 1992

Cyclic aminophenylacetic acid derivatives, process for preparing the same and immune response modulator having the same as an effective ingredient

Yasushi Kohno; Katsuya Awano; Takayoshi Ishizaki; Eisuke Kojima; Shinji Kudoh; Yasuhiko Sakoe; Koji Saito

Archive | 1992

Process for the preparation of pharmacologically active 1,2,3,4-tetrahydroquinoline-6-e dart acid derivatives, and k to be used as an intermediate inoliinijohdannaiset

Takayoshi Ishizaki; Yasushi Kohno; Katsuya Awano; Eisuke Kojima; Shinji Kudoh; Yasuhiko Sakoe; Koji Saito

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Takayoshi Ishizaki

Purdue University

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