Shinryo Shinagawa

Cervical pregnancy as a possible sequela of induced abortion. Report of 19 cases.

Clinical details of 19 cases of cervical pregnancy are presented. None of the women were nulligravida and all had had at least 1 legal abortion. The interval between the last pregnancy and the cervical pregnancy ranged from 2 months to 8 years. 17 of the women were treated with total hysterectomy and 2 with partial hysterectomy. In all cases the vaginal hemorrhage was uncontrollable.

Foetal Head Growth Retardation due to Antiepileptic Drugs: With Reference to GH, TSH, T4. T3 and Reverse T3 Concentrations

Abstract: To study the mechanisms of inhibitory action of antiepileptic drugs on foetal head growth, determinations were made of the growth hormone, thyrotropin and thyroid hormone levels in the sera of pregnant women, and the correlations between each hormone concentration and the foetal head circumference were studied. The thyroxine level decreased in the maternal serum and in the cord blood, and the thyrotropin level also became lower in the epileptic mother taking antiepileptic drugs. The growth hormone level in the umbilical vein sample of the epileptic mother was lower than that in the controls. The correlations between the head circumference of an infant at delivery and the decreased levels of the hormones seemed to indicate that a decrease in the thyroxine level, caused by antiepileptic drugs, produced the foetal head growth retardation.

Anticoagulant release during shock

Abstract The anticoagulant release was observed in obstetrical shock and experimentally induced disseminated intravascular coagulation by endotoxin infusion into rabbits. The anticoagulant was partially purified from the incoagulable rabbit plasma by using salting out and chromatographic procedures. The experiment revealed that this anticoagulant had the following properties: 1. protein, approximate molecular weight of 60,000, 2. no antithrombin activity, 3. inhibition on thromboplastin generation and on factor VIII. The origin and significance of the substance are unknown. It may act as one of the defense mechanisms against disseminated intravascular coagulation.

Diagnosis of Fibrinolytic Hemorrhage

It is unusual to be able to obtain blood samples for laboratory examination from patients with fibrinolytic hemorrhage prior to the manifestation of bleeding. Therefore, some of the results obtained from laboratory tests may represent secondary changes due to fibrinolytic hemorrhage. In order to detect valuable diagnostic tools, the various tests for clotting and plasmin systems were carried out on 16 patients diagnosed as having fibrinolytic hemorrhage and on plasma in which fibrinolysis was artificially induced by streptokinase addition in vitro. The importance of measurements of clot-lysis time of the whole blood and whole plasma, prothrombin activity, thrombelastography, heparin tolerance test, fibringogen, factors of plasmin system, thrombin time, fibrinogen by turbido-metric method and erythrocytes sedimentation rate in cases of pregnancy was emphasized as diagnostic tools of fibrinolytic hemorrhage, especially the latter three due to their simplicity in technique.