Shirabe Ken

肝細胞癌の再発に対する肝移植時の腫瘍の大きさ、腫瘍の数、好中球とリンパ球の比の影響(Impact of tumor size, number of tumors and neutrophil-to-lymphocyte ratio in liver transplantation for recurrent hepatocellular carcinoma)

Hepatocellular carcinoma (HCC) is primarily treated with hepatic resection and/or locoregional therapy. When HCC recurs and further treatment is no longer possible owing to poor liver function, liver transplantation (LT) or living‐donor LT (LDLT) is considered. The aim of this study was to clarify risk factors for tumor recurrence after LDLT in patients with recurrent HCC.

脾臓由来のエンドセリン-1は続発性胆汁性肝硬変のラットにおいてRhoキナーゼ経路を活性化した(Endothelin-1 derived from spleen-activated Rho-kinase pathway in rats with secondary biliary cirrhosis)

Aim:  Splenectomy or partial splenic embolism has been reported to improve liver function in patients with hypersplenism and liver dysfunction. The aim of this study was to investigate the mechanism of improvement after splenectomy.

Acoustic radiation force impulseで評価したドナー肝切除後の残存肝および脾臓の硬さにおける経時変化 予備的研究(Temporal changes in the stiffness of the remnant liver and spleen after donor hepatectomy as assessed by acoustic radiation force impulse: A preliminary study)

Aim:  Virtual touch tissue quantification (VTTQ) is an implementation of ultrasound acoustic radiation force impulse imaging that provides numerical measurements of tissue stiffness. We have evaluated the temporal changes of the remnant liver and spleen after living donor hepatectomy with special reference to the differences between right and left liver donation.

肝移植後にC型肝炎を再発した患者に生じる貧血を防止するための脾臓除去の効果はイノシン三リン酸ピロホスファターゼの遺伝子型に依存しない(Efficacy of splenectomy in preventing anemia in patients with recurrent hepatitis C following liver transplantation is not dependent on inosine triphosphate pyrophosphatase genotype)

Aim:  A genetic polymorphism of inosine triphosphate pyrophosphatase (ITPA) has been associated with pegylated‐interferon/ribavirin (PEG‐IFN/RBV)‐induced anemia in chronic hepatitis C patients. However, correlation of the genetic variant with anemia following liver transplantation has not been determined.