Shon Roland Pulley
Eli Lilly and Company
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Publication
Featured researches published by Shon Roland Pulley.
Experimental Hematology | 2008
Chandrasekar V. Iyer; Robert J. Evans; Qinyuan Lou; Datian Lin; Jian Wang; Wayne David Kohn; Liang Zeng Yan; Shon Roland Pulley; Sheng-Bin Peng
The CXCR4/stromal cell-derived factor-1 (SDF-1) axis plays important roles in development, leukocyte trafficking, HIV infection, and tumorigenesis. Its critical function in bone marrow stem cell and hematopoietic progenitor cell retention, homing and release has been well-characterized by genetic and pharmacological analyses. However, its role in neutrophil retention and release is still poorly understood. In this study, we demonstrated that T134, a peptide antagonist of human CXCR4, is also a potent antagonist of mouse CXCR4. Treatment of C57BL/6 mice with T134 resulted in a rapid and time-dependent increase of white blood cells (WBC) and neutrophils, as well as hematopoietic stem and progenitor cells in peripheral blood. Interestingly, recurrent WBC and neutrophil mobilization was achieved by repeated T134 treatment, and the T134-mediated increase and subsequent retreat of WBC and neutrophils correlated with T134 activity in the peripheral blood. Kinetic analysis revealed that T134 binding to CXCR4 did not induce any significant cell-surface receptor downregulation, indicating that T134-induced WBC and neutrophil mobilization is likely due to direct blockage of the CXCR4/SDF-1 interaction. The results from this study support an important role of CXCR4/SDF-1 axis in neutrophil retention and release in the marrow.
Archive | 2007
Shon Roland Pulley
CCR5 is a prototypically inflammatory chemokine receptor belonging to the seven transmembrane G-protein-coupled receptor (GPCR) family. This family is generally considered druggable and well represented in marketed drugs [1]–[6]. The CCR5 receptor is expressed on numerous host defense cells including monocytes, macrophages, T-lymphocytes, dendritic cells and microglia [4, 5]. Interaction of CCR5 with its ligands MIP-1α, MIP-1β (CCL3/CCL4) or RANTES (CCL5) results in a conformational change in the seven transmembrane domain initiating a signaling cascade through heterotrimeric G-proteins ultimately giving rise to migration of immune cells to sites of inflammation [2, 5]. Due to the well documented role of CCR5 in the immune system, it has been implicated in the pathophysiology of rheumatoid arthritis (RA), multiple sclerosis (MS), transplant rejection, gastric disorders, diabetes and myeloma [7]. Perhaps the biggest driver behind the development of CCR5 receptor antagonists was the discovery that CCR5 plays an important role as a co-receptor for macrophage tropic HIV-1 strains to facilitate viral fusion and entry into host cells [5], [8]–[12]. In addition, individuals with a mutation in the CCR5 gene (CCR5Δ32) lacking expression of CCR5 on the cell surface are resistance to HIV-1 infection without notable immune system effects [13, 14], thus validating pharmaceutical intervention with a CCR5 antagonist.
Journal of Organic Chemistry | 2007
Brandon J. Margolis; Kimberly A. Long; Dana L. T. Laird; and J. Craig Ruble; Shon Roland Pulley
Archive | 2006
Larry C. Blaszczak; Brian Michael Mathes; Shon Roland Pulley; Michael Alan Robertson; Scott Martin Sheehan; Qing Shi; Brian Morgan Watson; Michael Robert Wiley
Bioorganic & Medicinal Chemistry Letters | 2007
Scott Martin Sheehan; Hans-Juergen Mest; Brian Morgan Watson; Valentine J. Klimkowski; David E. Timm; Annick J. Cauvin; Stephen Parsons; Qing Shi; Emily J. Canada; Michael Robert Wiley; Gerd Ruehter; Britta Evers; Soenke Petersen; Larry C. Blaszczak; Shon Roland Pulley; Brandon J. Margolis; Graham N. Wishart; Beatrice Renson; Dirk Hankotius; Michael Mohr; Johann-Christian Zechel; J. Michael Kalbfleisch; Elizabeth Anne Dingess-Hammond; Andre Boelke; Andreas Gerhard Weichert
Archive | 2014
Shuhui Chen; Jean Marie Defauw; Scott Dale Holmstrom; Shon Roland Pulley; William Hunter White; Joseph Raymond Winkle; Wentao Wu; Yang Zhang
Archive | 2006
Larry C. Blaszczak; Shon Roland Pulley; Michael Alan Robertson; Scott Martin Sheehan; Qing Shi; Michael Robert Wiley
Archive | 2014
Tsutomu Akama; Kurt Jarnagin; Jacob J. Plattner; Shon Roland Pulley; William Hunter White; Yong-Kang Zhang; Yasheen Zhou
Archive | 2014
Shon Roland Pulley; William Hunter White; Tsutomu Akama; Kurt Jarnagin; Jacob J. Plattner; Yong-Kang Zhang; Yasheen Zhou
Archive | 2014
Shon Roland Pulley; William Hunter White; Tsutomu Akama; Kurt Jarnagin; Jacob J. Plattner; Yong-Kang Zhang; Yasheen Zhou