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Featured researches published by Shoo K. Lee.


Journal of Pediatric Surgery | 2008

Canadian Pediatric Surgical Network: a population-based pediatric surgery network and database for analyzing surgical birth defects. The first 100 cases of gastroschisis

Erik D. Skarsgard; Jennifer Claydon; Sarah Bouchard; Peter Kim; Shoo K. Lee; Jean-Martin Laberge; Douglas McMillan; Peter von Dadelszen; Natalie L. Yanchar

PURPOSE Outcomes studies for gastroschisis are constrained by small numbers, prolonged accrual, and nonstandardized data collection. The aim of this study is to create a national pediatric surgical network and database for gastroschisis (GS) that tracks cases from diagnosis to hospital discharge. METHODS The 16-center network serves a population of 32 million. Gastroschisis cases are ascertained at prenatal diagnosis. Perinatal data include maternal risk and fetal ultrasound variables, delivery plan and outcome, a postnatal bowel injury score, intended and actual surgical treatment, and neonatal outcomes. Institutional review board-approved data collection conforms to regional privacy legislation. Deidentified data are centralized and accessible for research through the network steering committee. RESULTS To date, 114 cases of pre- and/or postnatal gastroschisis have been uploaded. Of 106 live-born infants (40 [38%] by cesarean delivery), 100 had complete records, and overall survival to discharge was 96%, with a mean survivor length of stay (LOS) of 46 days. Infants treated with attempted urgent closure (61%) had significantly shorter LOS (42 vs 57 days; P = .048) but comparable LOS compared with those treated with silos and delayed closure. Fetal bowel dilation 18 mm or greater did not predict a difference in outcome. CONCLUSION Population-based databases allow rapid case accrual and enable studies that should aid in the identification of optimal perinatal treatment.


BMC Pediatrics | 2005

Actuarial survival of a large Canadian cohort of preterm infants

Huw P. Jones; Stella Karuri; Catherine M Cronin; Arne Ohlsson; Abraham Peliowski; Anne Synnes; Shoo K. Lee

BackgroundThe increased survival of preterm and very low birth weight infants in recent years has been well documented but continued surveillance is required in order to monitor the effects of new therapeutic interventions. Gestation and birth weight specific survival rates most accurately reflect the outcome of perinatal care. Our aims were to determine survival to discharge for a large Canadian cohort of preterm infants admitted to the neonatal intensive care unit (NICU), and to examine the effect of gender on survival and the effect of increasing postnatal age on predicted survival.MethodsOutcomes for all 19,507 infants admitted to 17 NICUs throughout Canada between January 1996 and October 1997 were collected prospectively. Babies with congenital anomalies were excluded from the study population. Gestation and birth weight specific survival for all infants with birth weight <1,500 g (n = 3419) or gestation ≤30 weeks (n = 3119) were recorded. Actuarial survival curves were constructed to show changes in expected survival with increasing postnatal age.ResultsSurvival to discharge at 24 weeks gestation was 54%, compared to 82% at 26 weeks and 95% at 30 weeks. In infants with birth weights 600–699, survival to discharge was 62%, compared to 79% at 700–799 g and 96% at 1,000–1,099 g. In infants born at 24 weeks gestational age, survival was higher in females but there were no significant gender differences above 24 weeks gestation. Actuarial analysis showed that risk of death was highest in the first 5 days. For infants born at 24 weeks gestation, estimated survival probability to 48 hours, 7 days and 4 weeks were 88 (CI 84,92)%, 70 (CI 64, 76)% and 60 (CI 53,66)% respectively. For smaller birth weights, female survival probabilities were higher than males for the first 40 days of life.ConclusionActuarial analysis provides useful information when counseling parents and highlights the importance of frequently revising the prediction for long term survival particularly after the first few days of life.


Obstetrics & Gynecology | 2008

Comparison of singleton and multiple-birth outcomes of infants born at or before 32 weeks of gestation

Xiangming Qiu; Shoo K. Lee; Kenneth Tan; Bruno Piedboeuf; Rody Canning

OBJECTIVE: To compare the outcomes of multiple-birth and singleton very preterm infants who were admitted to neonatal intensive care units (NICUs). METHODS: Three-level hierarchical generalized linear and hierarchical linear model analyses were used to compare the risk-adjusted outcomes of 3,242 infants born at or before 32 weeks of gestational age who were admitted to 24 Canadian NICUs in 2005. RESULTS: With the exception of respiratory distress syndrome (RDS), multiple-birth infants were not at a higher risk than singleton birth infants for death, patent ductus arteriosus, necrotizing enterocolitis, chronic lung disease, severe intraventricular hemorrhage, severe (stages 3 or higher) retinopathy of prematurity, or nosocomial infection, after adjusting for perinatal risks and neonatal illness severity. In addition, multiple-birth infants did not have a more prolonged duration of neonatal intensive care unit stay, duration of length of continuous positive airway pressure use, duration of ventilation, or duration of oxygen use than did singletons. Multiple-birth infants had a higher incidence of RDS (adjusted odds ratio 1.3, 95% confidence interval 1.0–1.6) and a lower incidence of severe retinopathy of prematurity (adjusted odds ratio 0.5, 95% confidence interval 0.3–0.9) than did singletons. CONCLUSION: Multiple-birth and singleton very preterm infants had similar outcomes, except for a higher incidence of RDS among multiple-birth infants. LEVEL OF EVIDENCE: II


American Journal of Physiology-heart and Circulatory Physiology | 2009

Sodium tanshinone IIA sulfonate increased intestinal hemodynamics without systemic circulatory changes in healthy newborn piglets

Jiang-Qin Liu; Jude S. Morton; Margaret Miedzyblocki; Tze Fun Lee; David L. Bigam; Tai Fai Fok; Chao Chen; Shoo K. Lee; Sandra T. Davidge; Po-Yin Cheung

In traditional Chinese medicine, tanshinone IIA is a lipid-soluble component of Danshen that has been widely used for various cardiovascular and cerebrovascular disorders, including neonatal asphyxia. Despite promising effects, little is known regarding the hemodynamic effects of tanshinone IIA in newborn subjects. To examine the dose-response effects of sodium tanshinone IIA sulfonate (STS) on systemic and regional hemodynamics and oxygen transport, 12 newborn piglets were anesthetized and acutely instrumented for the placement of femoral arterial and venous, pulmonary arterial catheters to measure mean arterial, central venous, and pulmonary arterial pressures, respectively. The blood flow at the common carotid, renal, pulmonary, and superior mesenteric (SMA) arteries were continuously monitored after treating the piglets with either STS (0.1-30 mg/kg iv) or saline treatment (n = 6/group). To further delineate the underlying mechanisms for vasorelaxant effects of STS, in vitro vascular myography was carried out to compare its effect on rat mesenteric and carotid arteries (n = 4-5/group). STS dose-dependently increased the SMA blood flow and the corresponding oxygen delivery with no significant effect on systemic and pulmonary, carotid and renal hemodynamic parameters. In vitro studies also demonstrated that STS selectively dilated rat mesenteric but not carotid arteries. Vasodilation in mesenteric arteries was inhibited by apamin and TRAM-34 (calcium-activated potassium channel inhibitors) but not by meclofenamate (cyclooxygenase inhibitor) or N-nitro-l-arginine methyl ester hydrochloride (nitric oxide synthase inhibitor). In summary, without significant hemodynamic effects on newborn piglets, intravenous infusion of STS selectively increased mesenteric perfusion in a dose-dependent manner, possibly via an endothelium-derived hyperpolarizing factor vasodilating pathway.


The Lancet | 2008

Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial.

Kellie Murphy; Mary E. Hannah; Andrew R. Willan; Sheila Hewson; Arne Ohlsson; Edmond Kelly; Stephen G. Matthews; Saroj Saigal; Elizabeth Asztalos; Susan Ross; Marie-France Delisle; Kofi Amankwah; Patricia Guselle; Amiram Gafni; Shoo K. Lee; B. Anthony Armson


Journal of Pediatric Surgery | 2012

The gastroschisis prognostic score: reliable outcome prediction in gastroschisis☆☆☆

Kyle N. Cowan; Pramod S. Puligandla; Jean-Martin Laberge; Erik D. Skarsgard; Sarah Bouchard; Natalie L. Yanchar; Peter K. Kim; Shoo K. Lee; Douglas McMillan; Peter von Dadelszen


Journal of Evaluation in Clinical Practice | 2007

A qualitative examination of changing practice in Canadian neonatal intensive care units

Bonnie Stevens; Shoo K. Lee; Madelyn P. Law; Janet Yamada


Paediatrics and Child Health | 2008

Nasal continuous positive airway pressure and outcomes in preterm infants: A retrospective analysis.

Gustavo Pelligra; Mohamed A Abdellatif; Shoo K. Lee


Archive | 2012

Effect of Fresh Red Blood Cell Transfusions on Clinical Outcomes in Premature, Very Low-Birth-Weight Infants

Dean Fergusson; Debora L. Hogan; Louise LeBel; Nicole Rouvinez-Bouali; John A. Smyth; Morris A. Blajchman; Lajos Kovacs; Christian Lachance; Shoo K. Lee; C. Robin Walker; Brian Hutton; Katelyn Balchin; Tim Ramsay; Jason C. Ford; Ashok Kakadekar; Stan Shapiro


/data/revues/00223476/unassign/S0022347617315949/ | 2018

Neurodevelopmental Outcomes of Infants Born at <29 Weeks of Gestation Admitted to Canadian Neonatal Intensive Care Units Based on Location of Birth

Reem Amer; Mary Seshia; Ruben Alvaro; Anne Synnes; Kyong-Soon Lee; Shoo K. Lee; Prakesh S. Shah

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Marie-France Delisle

University of British Columbia

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