Shoso Munemasa
Hiroshima University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Shoso Munemasa.
British Journal of Haematology | 2007
Shoso Munemasa; Akira Sakai; Yoshiaki Kuroda; Yoshiko Okikawa; Yuta Katayama; Hideki Asaoku; Tadahiko Kubo; Yoshitaka Miyakawa; Masahiro Serikawa; Tamito Sasaki; Akiro Kimura
Bone disease (BD) in multiple myeloma (MM) is because of the activation of osteoclasts and impairment of osteoblast differentiation. Connective tissue growth factor (CTGF) is known to participate in the differentiation of mesenchymal stem cells to committed osteoprogenitor cells. We analysed the concentration of circulating CTGF in 35 MM patients and 22 malignant lymphoma (ML) patients and 14 normal individuals. CTGF is protease‐sensitive and thus is found as both an N‐terminal half fragment (N‐half CTGF) and whole (W‐CTGF). Serum levels of W‐CTGF and N‐half CTGF + W‐CTGF were determined by separate sandwich enzyme‐linked immunosorbent assays. The level of W‐CTGF was significantly lower (P < 0·005) in MM patients compared with ML patients and normal individuals, while N‐half + W‐CTGF was similar in all groups. Furthermore, W‐CTGF was significantly lower in MM patients with BD compared with those without BD (P < 0·005) and this was independent of previous treatment. Matrix metalloproteinase (MMP)‐9 is produced by myeloma cells and is thought to be related to BD in MM. However, MMP‐9 does not cleave CTGF and serum MMP‐9 level was not related to BD in MM. Thus, CTGF is an indicator of BD in MM; its metabolism and function in MM should be clarified.
International Journal of Hematology | 2005
Yoshiaki Kuroda; Akira Sakai; Yoshiko Okikawa; Shoso Munemasa; Yuta Katayama; Hideo Hyodo; Jun Imagawa; Yasuo Takimoto; Hajime Okita; Megu Ohtaki; Akiro Kimura
We analyzed both morphologic and phenotypic findings of myeloma cells before and after chemotherapy in 21 patients with multiple myeloma. The morphologic analysis was based on the Greipp classification, and phenotypic analysis was performed by 3-color flow cytometry using the CD38 plasma gating method (Marrow plasma 38). Results with flow cytometry using a combination of MPC1, CD49e, and CD45 supported the morphologic findings for the myeloma cells. Treatment with 3 or 4 cycles of VAD (vincristine, doxorubicin, and dexamethasone) therapy was effective in reducing the total numbers of myeloma cells, but the proportion of immature myeloma cells increased after this treatment. However, the immature myeloma cells were reduced by high-dose melphalan (HD-Mel) therapy followed by autologous stem cell transplantation (ASCT). High-dose cyclophosphamide treatment for stem cell harvesting did not show an effect on the residual immature myeloma cells after VAD treatment. In addition, thalidomide was not effective in reducing the numbers of immature myeloma cells. These results suggest that VAD (3 or 4 cycles) therapy plus HD-Mel followed by ASCT is a reasonable treatment for multiple myeloma and that Marrow plasma 38 analysis is a useful method for monitoring the response of multiple myeloma to chemotherapy.
International Journal of Oncology | 2008
Shoso Munemasa; Akira Sakai; Yoshiaki Kuroda; Yoshiko Okikawa; Yuta Katayama; Hideki Asaoku; Tadahiko Kubo; Shoji Shimose; Akiro Kimura
International Journal of Oncology | 1992
Yoshiaki Kuroda; Akira Sakai; Naohiro Tsuyama; Yuta Katayama; Shoso Munemasa; Hideki Asaoku; Yoshiko Okikawa; Nanae Nakaju; Mami Mizuno; Katsunari Ogawa; Takashi Nishisaka; Hirotaka Matsui; Hideo Tanaka; Akiro Kimura
Blood | 2007
Shoso Munemasa; Akira Sakai; Yoshiaki Kuroda; Yoshiko Okikawa; Yuta Katayama; Hideki Asaoku; Tadahiko Kubo; Shoji Shimose; Akiro Kimura
Blood | 2007
Yoshiaki Kuroda; Akira Sakai; Naohiro Tsuyama; Yuta Katayama; Shoso Munemasa; Yoshiko Okikawa; Hideki Asaoku; Nanae Nakaju; Mami Mizuno; Takashi Nishizaka; Katsunari Ogawa; Hideo Tanaka; Akiro Kimura
Blood | 2006
Shoso Munemasa; Akira Sakai; Yoshiaki Kuroda; Yoshiko Okikawa; Yuta Katayama; Hideki Asaoku; Tadahiko Kubo; Noelynn Oliver; Akiro Kimura
Blood | 2006
Yoshiaki Kuroda; Akira Sakai; Naohiro Tsuyama; Shoso Munemasa; Nanae Nakaju; Mami Mizuno; Yoshiko Okikawa; Yuta Katayama; Akiro Kimura
Blood | 2005
Yoshiaki Kuroda; Akira Sakai; Naohiro Tsuyama; Mami Mizuno; Nanae Nakaju; Shoso Munemasa; Yoshiko Okikawa; Yuta Katayama; Akiro Kimura
Blood | 2004
Yoshiaki Kuroda; Akira Sakai; Yoshiko Okikawa; Shoso Munemasa; Yuta Katayama; Yasuo Takimoto; Hajime Okita; Akiro Kimura