Shouming Wang

Studies on Quinazolinones as Dual Inhibitors of Pgp and MRP1 in Multidrug Resistance

The syntheses and SAR studies of various quinazolinone compounds are described for the dual inhibition of Pgp and MRP1 in multidrug resistance.

Novel inhibitors of plasminogen activator inhibitor-1: Development of new templates from diketopiperazines

Several isoquinoline-based templates were identified from the studies of the conformational effects of the diketopiperazine structures for PAI-1 inhibition. Moderate to good activity was retained with the elimination of unattractive characteristics in the diketopiperazine template.

Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1.

We have synthesized and evaluated a series of tetramic acid-based and hydroxyquinolinone-based inhibitors of plasminogen activator inhibitor-1 (PAI-1). These studies resulted in the identification of several compounds which showed excellent potency against PAI-1. The design, synthesis and SAR of these compounds are described.

Higher Rydberg states of C6H6, C6D6 and C6H5F studied by two-photon resonance ionization spectroscopy

The higher Rydberg states of jet-cooled C6H6, C6D6(n⩽30) and C6H5F(n⩽13) have been studied using two-photon resonance-enhanced multiphoton ionization (REMPI) spectroscopy. In C6H6 and C6D6 long series of three gerade nd Rydberg series converging on the first ionization potential, previously observed up to n=8, are extended up to n=30. The spectra are dominated by origin transitions with only weak vibrational structure being observed. The series with A1g and E1g or E2g symmetry were distinguished by polarization experiments. Similar long series of three nd Rydberg states are also observed for C6H5F and are reported here for the first time. In contrast to benzene, more vibrational activity, especially in ν6a was observed, and thus Rydberg series can only be resolved up to n=12 for C6H5F.

Formation of O2(b 1Σg+) in the ultraviolet photolysis of O3

The formation of O2(b 1Σg+) in the ultraviolet photodissociation of O3 (335–352 nm) has been observed for the first time using (2+1) resonance enhanced multiphoton ionization. Measurement of the photofragment kinetic energy confirms that the primary photodissociation step involves the absorption of a single photon.

Continuously tunable high-flux VUV beamline constructed on a picosecond KrF laser plasma source

Leading edge research in molecular dynamics, photoelectron spectroscopy, surface interactions and radiobiology has pushed forward the requirement for intense, pulsed, tunable sources of vacuum ultraviolet radiation. Presently, only synchrotron radiation sources are sufficiently bright for these applications. A bright, continuously tunable VUV beamline capable of delivering in excess of 1013 photons/sec/cm2/1nm BW 100 nm, 50 Hz repetition rate (BW equals (Delta) (lambda) /(lambda) is the bandwidth) to the sample, has been constructed on a plasma source generated by a high repetition rate, picosecond KrF excimer laser system.