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Featured researches published by Shuang Zhang.


PLOS ONE | 2015

Prevalence of Gestational Diabetes Mellitus and Its Risk Factors in Chinese Pregnant Women: A Prospective Population-Based Study in Tianjin, China

Junhong Leng; Ping Shao; Cuiping Zhang; Huiguang Tian; Fuxia Zhang; Shuang Zhang; Ling Dong; Lili Li; Zhijie Yu; Juliana C.N. Chan; Gang Hu; Xilin Yang

Objective We compared the increases in the prevalence of gestational diabetes mellitus (GDM) based on the 1999 World Health Organization (WHO) criteria and its risk factors in Tianjin, China, over a 12-year period. We also examined the changes in the prevalence using the criteria of International Association of Diabetes and Pregnancy Study Group (IADPSG). Methods In 2010-2012, 18589 women who registered within 12 weeks of gestation underwent a glucose challenge test (GCT) at 24-28 gestational weeks. Amongst them, 2953 women with 1-hour plasma glucose ≥7.8 mmol/L underwent a 75-gram 2-hour oral glucose tolerance test (OGTT) and 781 women had a positive GCT but absented from the standard OGTT. An adjusted prevalence of GDM was calculated for the whole cohort of women by including an estimate of the proportion of women with positive GCTs who did not have OGTTs but would have been expected to have GDM. Logistic regression was used to obtain odds ratios and 95% confidence intervals using the IADPSG criteria. The prevalence of GDM risk factors was compared to the 1999 survey. Results The adjusted prevalence of GDM by the 1999 WHO criteria was 8.1%, a 3.5-fold increase as in 1999. Using the IADPSG criteria increased the adjusted prevalence further to 9.3%. Advanced age, higher pre-pregnancy body mass index, Han-nationality, higher systolic blood pressure (BP), a family history of diabetes, weight gain during pregnancy and habitual smoking were risk factors for GDM. Compared to the 1999 survey, the prevalence of overweight plus obesity had increased by 1.8 folds, age≥30 years by 2.3 folds, systolic BP by 2.3 mmHg over the 12-year period. Conclusions Increasing prevalence of overweight/obesity and older age at pregnancy were accompanied by increasing prevalence of GDM, further increased by change in diagnostic criteria.


Diabetes Research and Clinical Practice | 2012

Tianjin Gestational Diabetes Mellitus Prevention Program: study design, methods, and 1-year interim report on the feasibility of lifestyle intervention program.

Gang Hu; Huiguang Tian; Fuxia Zhang; Huikun Liu; Cuiping Zhang; Shuang Zhang; Leishen Wang; Gongshu Liu; Zhijie Yu; Xilin Yang; Lu Qi; Cuilin Zhang; Hua Wang; Min Li; Junhong Leng; Yi Li; Ling Dong; Jaakko Tuomilehto

OBJECTIVEnTo assess whether lifestyle intervention can reduce type 2 diabetes risk in women with prior GDM in the Tianjin Gestational Diabetes Mellitus (GDM) Prevention Program.nnnMETHODSn1180 women who were diagnosed with GDM from 2005 to 2009 were randomly assigned to either a lifestyle intervention (n=586) or a control group (n=594). Major elements of the intervention include six face-to-face meetings with study dietitians in the first year, and two additional sessions and two telephone calls in second year.nnnRESULTSnDuring the first year, average body weight loss in the first 404 subjects was 1.40 kg (2.1%) in the intervention group vs 0.21 kg (0.3%) in the control group (P=0.001), and the decrease was more significant among baseline overweight women (body bass index [BMI]≥24 kg/m²) in the intervention (2.91 kg/4.2%) compared with that in the control group (0.51 kg/0.7%) (P<0.001). In addition, women in the intervention group, compared with those in the control group, have decreased BMI, body fat, waist circumference, and plasma insulin levels, and have improved behaviors including increased leisure time activity and dietary fiber intake and decreased sedentary time and fat consumptions.nnnCONCLUSIONnThe interim results support the efficacy and feasibility of the lifestyle intervention program.


Obesity | 2014

Prepregnancy body mass index and weight change on postpartum diabetes risk among gestational diabetes women

Huikun Liu; Cuiping Zhang; Shuang Zhang; Leishen Wang; Junhong Leng; Dongdong Liu; Han Fang; Weiqin Li; Zhijie Yu; Xilin Yang; Ling Dong; Gang Hu

To evaluate the effects of prepregnancy BMI and weight change from prepregnancy to postpartum on postpartum type 2 diabetes (T2D) risk among women with gestational diabetes (GDM).


Diabetes Care | 2014

Different Associations of Diabetes With β-Cell Dysfunction and Insulin Resistance Among Obese and Nonobese Chinese Women With Prior Gestational Diabetes Mellitus

Weiqin Li; Shuang Zhang; Huikun Liu; Leishen Wang; Cuiping Zhang; Junhong Leng; Zhijie Yu; Xilin Yang; Huiguang Tian; Gang Hu

OBJECTIVE To examine the relative contributions of β-cell dysfunction and insulin resistance to postpartum diabetes risk among obese and nonobese women with prior gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS We performed a cross-sectional survey 1–5 years after 1,263 women who had GDM gave birth. Polytomous logistic regression models were used to assess the associations of β-cell dysfunction (the lower quartile of HOMA-%β), insulin resistance (the upper quartile of HOMA-IR), decreased insulin sensitivity (the lower quartile of HOMA-%S), and different categories of BMI with prediabetes and diabetes risk. RESULTS β-Cell dysfunction, insulin resistance, and decreased insulin sensitivity all were significantly associated with hyperglycemic status across normal weight, overweight, and obese groups, and the patterns of insulin resistance and decreased insulin sensitivity were similar. BMI was inversely associated with β-cell dysfunction and positively associated with insulin resistance across normal glucose, prediabetes, and diabetes categories. Compared with women with normal glucose and weight, obese women with normal glucose had increased β-cell secretory function (odds ratio [OR] 0.09 [95% CI 0.02–0.37]) and insulin resistance (OR 17.4 [95% CI 9.47–31.9]). Normal weight diabetic women displayed the most β-cell dysfunction (OR 13.6 [95% CI 4.06–45.3]), whereas obese diabetic women displayed the highest insulin resistance (OR 45.8 [95% CI 18.5–113]). CONCLUSIONS For women with prior GDM, β-cell dysfunction had more pronounced contribution to postpartum diabetes among nonobese subjects, whereas insulin resistance contributed more to postpartum hyperglycemia among obese subjects.


Diabetic Medicine | 2014

Obesity index and the risk of diabetes among Chinese women with prior gestational diabetes.

Leishen Wang; Huikun Liu; Shuang Zhang; Junhong Leng; Gongshu Liu; Cuiping Zhang; Weiqin Li; Nan Li; Wei Li; Yi Li; Shurong Sun; Zhijie Yu; Xilin Yang; Gang Hu

There is some confusion regarding which anthropometric measurement of adiposity should be used to indicate diabetes, especially for Asians. The present study was to evaluate different indicators of adiposity (BMI, waist circumference and body fat) with Type 2 diabetes risk among women with prior gestational diabetes mellitus.


PLOS ONE | 2015

GDM Women’s Pre-Pregnancy Overweight/Obesity and Gestational Weight Gain on Offspring Overweight Status

Junhong Leng; Weiqin Li; Shuang Zhang; Huikun Liu; Leishen Wang; Gongshu Liu; Nan Li; Leanne M. Redman; Andrea Baccarelli; Lifang Hou; Gang Hu

Objectives To examine the association of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) with anthropometry in the offspring of mothers with gestational diabetes mellitus (GDM). Methods We performed a retrospective cohort study in 1263 GDM mother-child pairs. General linear models and Logistic regression models were used to assess the single and joint associations of maternal pre-pregnancy BMI (normal weight, overweight, and obesity) and GWG (inadequate, adequate and excessive GWG) with anthropometry and overweight status in the offspring from birth to 1-5 years old. Results Maternal pre-pregnancy BMI and GWG were positively associated with birth weight for gestational age Z score and birth weight for length for gestational age Z score at birth, and weight for age Z score, length/height for age Z score, and weight for length/height Z score at of 1-5 years old offspring. Maternal pre-pregnancy overweight, obesity, and excessive GWG were associated with increased risks of large for gestational age [ORs 95% CIs = 1.87 (1.37-2.55), 2.98 (1.89-4.69), and 2.93 (2.07-4.13), respectively] and macrosomia [ORs 95% CIs = 2.06 (1.50-2.84), 2.89 (1.78-4.70), and 2.84 (1.98-4.06), respectively] at birth and childhood overweight at 1-5 years old [ORs 95% CIs = 1.26 (0.92-1.73), 1.96 (1.24-3.09), and 1.59 (1.15-2.21), respectively]. Conclusions Offspring born to GDM mothers with pre-pregnancy overweight/obesity or excessive GWG were associated with increased risks of large for gestational age and macrosomia at birth, and childhood overweight at 1-5 years old, compared with those born to GDM mothers with pre-pregnancy normal weight and adequate GWG.


Diabetes Research and Clinical Practice | 2016

Fasting and 2-hour plasma glucose, and HbA1c in pregnancy and the postpartum risk of diabetes among Chinese women with gestational diabetes

Huikun Liu; Shuang Zhang; Leishen Wang; Junhong Leng; Weiqin Li; Nan Li; Min Li; Yijuan Qiao; Huiguang Tian; Jaakko Tuomilehto; Xilin Yang; Zhijie Yu; Gang Hu

AIMSnVery few studies have assessed the association of fasting and 2h glucose, and HbA1c during pregnancy with postpartum diabetes risk among women with prior gestational diabetes mellitus (GDM). We assessed the association of fasting glucose, 2h glucose and HbA1c at 26-30 gestational weeks with postpartum diabetes risk among women with prior GDM.nnnMETHODSnA cohort study in 1263 GDM women at 1-5 years after delivery was performed. Cox proportional hazards regression models were used to evaluate the association of fasting and 2h plasma glucose, and HbA1c at 26-30 gestational weeks with the risk of diabetes at postpartum.nnnRESULTSnThe multivariable-adjusted (age, pre-pregnancy body mass index, weight gain during pregnancy, current body mass index, family history of diabetes, marital status, education, family income, smoking status, passive smoking, leisure-time physical activity, alcohol drinking, and intake of energy, saturated fat, and dietary fiber) hazard ratios of postpartum diabetes were 1.61 (95% confidence interval [CI]: 1.36-1.91) for each 1 mmol/l increase in fasting glucose during pregnancy, 1.63 (95% CI: 1.45-1.84) for each 1 mmol/l increase in 2h glucose during pregnancy, 2.11 (95% CI: 1.50-2.97) for each 1 unit (%) increase in HbA1c during pregnancy. When fasting glucose, 2h glucose and HbA1c during pregnancy were entered multivariable-adjusted model simultaneously, 2h glucose and HbA1c but not fasting glucose remained to be significant and positive predictors for postpartum diabetes.nnnCONCLUSIONSnFor women with prior GDM, 2h plasma glucose and HbA1c during pregnancy are independent predictors of postpartum diabetes, but fasting plasma glucose during pregnancy is not.


Diabetic Medicine | 2017

Sleep duration and quality, and risk of gestational diabetes mellitus in pregnant Chinese women

Hua Wang; Junhong Leng; Weiqin Li; Leishen Wang; Cuiping Zhang; Huikun Liu; Shuang Zhang; Juliana C.N. Chan; Gang Hu; Zhijie Yu; Xilin Yang

To examine the association between sleep disturbances during pregnancy and risk of gestational diabetes mellitus.


European Journal of Endocrinology | 2018

Gestational diabetes with diabetes and prediabetes risks: a large observational study

Yun Shen; Peng Wang; Leishen Wang; Shuang Zhang; Huikun Liu; Weiqin Li; Nan Li; Wei Li; Junhong Leng; Jing Wang; Huiguang Tian; Cuilin Zhang; Jaakko Tuomilehto; Xilin Yang; Zhijie Yu; Gang Hu

AIMSnTo compare risks of early postpartum diabetes and prediabetes in Chinese women with and without gestational diabetes mellitus (GDM) during pregnancy.nnnSUBJECTS AND METHODSnTianjin GDM observational study included 1263 women with a history of GDM and 705 women without GDM who participated in the urban GDM universal screening survey by using World Health Organizations criteria. Postpartum diabetes and prediabetes were identified after a standard oral glucose tolerance test. Cox proportional hazards regression was used to assess risks of postpartum diabetes and prediabetes between women with and without GDM.nnnRESULTSnDuring a mean follow-up of 3.53 years postpartum, 90 incident cases of diabetes and 599 incident cases of prediabetes were identified. Multivariable-adjusted hazard ratios among women with prior GDM, compared with those without it, were 76.1 (95% CI: 23.6-246) for diabetes and 25.4 (95% CI: 18.2-35.3) for prediabetes. When the mean follow-up extended to 4.40 years, 121 diabetes and 616 prediabetes cases were identified. Women with prior GDM had a 13.0-fold multivariable-adjusted risk (95% CI: 5.54-30.6) for diabetes and 2.15-fold risk (95% CI: 1.76-2.62) for prediabetes compared with women without GDM. The positive associations between GDM and the risks of postpartum diabetes and prediabetes were significant and persistent when stratified by younger and older than 30 years at delivery and normal weight and overweight participants.nnnCONCLUSIONSnThe present study indicated that women with prior GDM had significantly increased risks for postpartum diabetes and prediabetes, with the highest risk at the first 3-4 years after delivery, compared with those without GDM.


Scientific Reports | 2016

Plasma Levels of Alanine Aminotransferase in the First Trimester Identify High Risk Chinese Women for Gestational Diabetes.

Junhong Leng; Cuiping Zhang; Peng Wang; Nan Li; Weiqin Li; Huikun Liu; Shuang Zhang; Gang Hu; Zhijie Yu; Ronald Cw Ma; Juliana C.N. Chan; Xilin Yang

Alanine aminotransferase (ALT) predicts type 2 diabetes but it is uncertain whether it also predicts gestational diabetes mellitus (GDM). We recruited 17359 Chinese women with ALT measured in their first trimester. At 24–28u2009weeks of gestation, all women underwent a 50-gram 1-hour glucose challenge test (GCT) followed by a 75-gram 2-hour oral glucose tolerance test if GCT result was ≥7.8u2009mmol/L. Restricted cubic spline analysis was used to examine full-range risk associations of ALT levels with GDM. Relative excess risk due to interaction, attributable proportion due to interaction and synergy index were used to estimate additive interaction between high ALT and overweight/obesity for GDM. Finally, 1332 (7.7%) women had GDM. ALT levels were positively associated with GDM risk without a clear threshold. Using ALT levels <22u2009U/L as the referent, the middle ALT levels (≥22u2009to <40u2009U/L) [odds ratio (OR) (95% confidence intervals): 1.41(1.21–1.65)] and high ALT levels (≥40u2009U/L) [1.62 (1.31–2.00)] were associated with increased GDM risk. Maternal overweight/obesity greatly enhanced the OR of ALT ≥22u2009U/L from 1.44 (1.23–1.69) to 3.46 (2.79–4.29) with significant additive interactions. In conclusion, elevated ALT levels in the first trimester even within normal range predicted GDM risk, further enhanced by overweight/obesity.

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Junhong Leng

Tianjin Medical University

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Gang Hu

Pennington Biomedical Research Center

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Weiqin Li

Pennington Biomedical Research Center

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Nan Li

Pennington Biomedical Research Center

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Xilin Yang

Tianjin Medical University

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