Shugo Atsuumi

An efficient enantioselective preparation of 2-substituted-3-hydroxypropionic acids via chemo-enzymatic reaction

Abstract The key intermediates, 2-substituted-3-hydroxypropionic acids 1 , of the potent renin inhibitors were synthesized enantioselectively starting from 2-substituted-l,3-propanediols via chemo-enzymatic reaction.

A stereospecific synthesis of a renin inhibitor(BW-175) which incorporates a sulfonemethylene isostere and a dihydroxyethylene isostere

Abstract (2 S , 3 R , 4 S )-4-[L-N-[(2 S )-3-ethylsulfonyl-2-(1-naphthylmethyl) propionyl]norleucyl]amino-5-cyclohexyl-1-morpholino-2,3-pentanediol(BW-175) was synthesized stereospecifically.

Stereospecific Synthesis of a Dihydroxyethylene Isostere of Cyclohexylalanine Amide, (2S,3R,4S)-4-Amino-5-Cyclohexyl-1-Morpholino-2,3-Pentanediol(ACMP) from a Protected Sugar

ABSTRACT A transition-state analogue of a renin inhibitor at the scissile site, a dihydroxyethylene isostere of cyclohexylalanine amide, (2S,3R,4S)-4-amino-5-cyclohexyl-1-morpholino-2,3-pentanediol(ACMP), was synthesized from 1,2:5,6-di-O-isopropylidene-α-D-allofuranose stereospecifically.