Shukri F. Khuri
Boston University
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Publication
Featured researches published by Shukri F. Khuri.
The Journal of Thoracic and Cardiovascular Surgery | 1999
Shukri F. Khuri; Nancy A. Healey; Hollace MacGregor; Marc R. Barnard; Irma O. Szymanski; Vladimir Birjiniuk; Alan D. Michelson; David R. Gagnon; C. Robert Valeri
OBJECTIVEnThe aim of the study was to compare the clinical effects and hemostatic efficiency of transfusions of platelets preserved in the frozen state for as long as 2 years with transfusions of platelets preserved in the conventional manner for as long as 5 days in patients undergoing cardiopulmonary bypass.nnnMETHODSnSeventy-three patients were prospectively randomly assigned to receive transfusions of cryopreserved or liquid-preserved platelets. Nonsurgical blood loss was measured during and after the operation. Bleeding time, hematologic variables, and the bleeding time site shed blood were assayed before cardiopulmonary bypass and at 30 minutes and 2, 4, and 24 hours after transfusion. In vitro platelet function tests were conducted on platelets obtained from healthy volunteers.nnnRESULTSnNo adverse sequelae of the transfusions were observed. Blood loss and the need for postoperative blood product transfusions were lower in the group receiving cryopreserved platelets. Lower posttransfusion platelet increments and a tendency toward decreased platelet survival were observed in patients receiving cryopreserved platelets. Hematocrit and plasma fibrinogen were significantly higher in this group, and the duration of intubation was shorter. In vitro, cryopreserved platelets demonstrated less aggregation, lower pH, and decreased response to hypotonic stress but generated more procoagulant activity and thromboxane.nnnCONCLUSIONSn(1) Cryopreserved platelet transfusions are superior to liquid-preserved platelets in reducing blood loss and the need for blood product transfusions after cardiopulmonary bypass. (2) The reduction in blood loss in the patients receiving cryopreserved platelet transfusions after cardiopulmonary bypass probably reflects improved in vivo hemostatic function of cryopreserved platelets. (3) Some in vitro measures of platelet quality (aggregation, pH, hypotonic stress) may not reflect in vivo quality of platelet transfusions after cardiopulmonary bypass, whereas other in vitro measures (platelet procoagulant activity and thromboxane) do.
Transfusion | 1999
Marc R. Barnard; Hollace MacGregor; Gina Ragno; Linda E. Pivacek; Shukri F. Khuri; Alan D. Michelson; C. R. Valeri
BACKGROUND: A study in humans showed that the transfusion of previously frozen human platelets after cardiopulmonary bypass, despite decreased survival, resulted in better hemostatic function than that of liquid‐preserved platelets stored at 22°C for 3 to 4 days.
Transfusion | 2005
C. R. Valeri; Gina Ragno; Shukri F. Khuri
BACKGROUND: Platelets (PLTs) can be frozen with 6u2003percent dimethyl sulfoxide (DMSO) at −80°C for up to 2u2003years. This method has been modified by concentrating the PLTs and removing the supernatant before freezing.
The Journal of Thoracic and Cardiovascular Surgery | 1992
Shukri F. Khuri; Wolfe Ja; Josa M; Trevor C. Axford; Szymanski I; Assousa S; Ragno G; Patel M; Silverman A; Park M
Archive | 2008
Hemant S. Thatte; Kunda Biswas; Shukri F. Khuri; Thomas Michel
Archive | 2005
Waleed Hassanein; Shukri F. Khuri; Michael D. Crittenden; Vladimir Birjinuik
American Journal of Physiology-heart and Circulatory Physiology | 1996
Gilbert R. Upchurch; C. R. Valeri; Shukri F. Khuri; Michael J. Rohrer; George N. Welch; Hollace MacGregor; G. Ragno; Stephanie Francis; Louis J. Rodino; Alan D. Michelson; Joseph Loscalzo
Archive | 2006
Hemant S. Thatte; Kunda Biswas; Shukri F. Khuri; Thomas Michel
Archive | 2017
Hemant S. Thatte; Laki Rousou; Patrick R. Treanor; Shukri F. Khuri
Archive | 2010
Shukri F. Khuri; Hemant S. Thatte; Laki Rousou; Kristin B. Taylor; Xiu-Gui Lu; Nancy A. Healey; Michael D. Crittenden