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Dive into the research topics where Shuntaro Mukai is active.

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Featured researches published by Shuntaro Mukai.


Endoscopy | 2014

Endoscopic ultrasound-guided placement of plastic vs. biflanged metal stents for therapy of walled-off necrosis: a retrospective single-center series

Shuntaro Mukai; Takao Itoi; Todd H. Baron; Atsushi Sofuni; Fumihide Itokawa; Toshio Kurihara; Takayoshi Tsuchiya; Kentaro Ishii; Shujiro Tsuji; Nobuhito Ikeuchi; Reina Tanaka; Junko Umeda; Ryosuke Tonozuka; Mitsuyoshi Honjo; Takuji Gotoda; Fuminori Moriyasu; Ichiro Yasuda

BACKGROUND AND STUDY AIMS Recently, a novel fully covered and biflanged metal stent (BFMS)dedicated to the drainage of walled-off necrosis(WON) was developed. The aim of this study was to retrospectively evaluate the safety, efficacy, and cost performance of drainage of WON using the novel BFMS compared with a traditional plastic stent. PATIENTS AND METHODS A total of 70 patients with symptomatic WON were treated under endoscopic ultrasound (EUS) guidance. Initial drainage was conducted using the single gateway technique with placement of one or more plastic stents or a single BFMS.If drainage was unsuccessful,direct endoscopic necrosectomy (DEN)was performed. RESULTS There were no statistically significant differences in rates of technical success, clinical success,and adverse events between plastics stents and BFMS, despite the size of WON in the BFMS group being significantly larger than that in the plastic stent group (105.6 vs. 77.1 mm; P=0.003).The mean procedure times for the first EUS-guided drainage and for re-intervention were significantly shorter in the BFMS group than in the plastic stent group (28.8±7.1 vs. 42.6±14.2, respectively,for drainage, P<0.001; and 34.9±8.5 vs.41.8±7.6, respectively, for re-intervention, P<0.001). There was no statistically significant difference in the total cost between plastic stent and BFMS use in the treatment of WON (


Gastrointestinal Endoscopy | 2015

A newly designed plastic stent for EUS-guided hepaticogastrostomy: a prospective preliminary feasibility study (with videos).

Junko Umeda; Takao Itoi; Takayoshi Tsuchiya; Atsushi Sofuni; Fumihide Itokawa; Kentaro Ishii; Shujiro Tsuji; Nobuhito Ikeuchi; Kentaro Kamada; Reina Tanaka; Ryosuke Tonozuka; Mitsuyoshi Honjo; Shuntaro Mukai; Mitsuru Fujita; Fuminori Moriyasu

5352vs.


Digestive Endoscopy | 2015

New fully covered large‐bore wide‐flare removable metal stent for drainage of pancreatic fluid collections: Results of a multicenter study

Amol Bapaye; Takao Itoi; Pradermchai Kongkam; Nachiket Dubale; Shuntaro Mukai

6274; P=0.25). CONCLUSIONS Plastic stents and BFMS were safe and effective for the treatment of WON. In particular,BFMS placement appeared to be preferable for initial EUS-guided drainage and additional reintervention(e.g. DEN) as it reduced the procedure time. Prospective randomized controlled trials are warranted.


Endoscopy | 2015

Initial evaluation of a new plastic pancreatic duct stent for endoscopic ultrasonography-guided placement.

Takao Itoi; Atsushi Sofuni; Takayoshi Tsuchiya; Kentaro Ishii; Nobuhito Ikeuchi; Reina Tanaka; Junko Umeda; Ryosuke Tonozuka; Mitsuyoshi Honjo; Shuntaro Mukai; Takako Takayama; Fuminori Moriyasu

BACKGROUND There are currently no dedicated plastic stents for EUS-guided hepaticogastrostomy (EUS-HGS). OBJECTIVE We prospectively evaluated the feasibility and the technical and functional success rates of our newly designed plastic stent for EUS-HGS. DESIGN Prospective preliminary feasibility study. SETTING A tertiary-care referral center. PATIENTS Twenty-three consecutive patients were treated. The reasons for requiring EUS-HGS were periampullary tumor invasion (n=9), altered anatomy (n=7), failed duodenal intubation (n=3), and previous ERCP failure (n=4). INTERVENTIONS An 8F single-pigtail plastic stent with 4 flanges was placed for EUS-HGS. MAIN OUTCOME MEASUREMENTS Technical success, clinical success, and adverse events according to the American Society for Gastrointestinal Endoscopy lexicon. RESULTS All stents were successfully deployed without procedural adverse events (100% technical success rate). Bleeding from the punctured gastric wall occurred in 1 patient 3 days postoperatively. We exchanged the plastic stent for a fully covered self-expandable metal stent. A mild adverse event of self-limited abdominal pain occurred in 3 patients. Treatment success was achieved in all patients. The occlusion rate was 13.7% (3/22) during the median follow-up period (5.0 months, range 0.5-12.5 months). The median duration of stent patency was 4.0 months (range 0.5-9.0 months). There was no stent migration or dislocation during the follow-up period. LIMITATIONS Small number of patients and lack of a control group. CONCLUSIONS This newly designed single-pigtail plastic stent dedicated for EUS-HGS was technically feasible and can possibly be used for highly selected patients with advanced malignancy or benign stricture. ( TRIAL REGISTRATION http://www.umin.ac.jp/english/: UMIN000012993.).


Endoscopic ultrasound | 2015

Clinical evaluation of endoscopic ultrasonography-guided drainage using a novel flared-type biflanged metal stent for pancreatic fluid collection

Shuntaro Mukai; Takao Itoi; Atsushi Sofuni; Takayoshi Tsuchiya; Takuji Gotoda; Fuminori Moriyasu

Endoscopic transmural drainage (ETMD) of peripancreatic fluid collections (PFC) is an effective alternative to surgical drainage. Conventional drainage using plastic stents has its limitations. A wide‐bore short‐length wide flange fully covered self‐expandable metallic stent (FCSEMS) has recently been developed. The present study evaluates the efficacy of this new FCSEMS for ETMD of PFC.


World Journal of Gastroenterology | 2014

Safety trial of high-intensity focused ultrasound therapy for pancreatic cancer

Atsushi Sofuni; Fuminori Moriyasu; Takatomo Sano; Fumihide Itokawa; Takayoshi Tsuchiya; Toshio Kurihara; Kentaro Ishii; Syujiro Tsuji; Nobuhito Ikeuchi; Reina Tanaka; Junko Umeda; Ryosuke Tonozuka; Mitsuyoshi Honjo; Shuntaro Mukai; Mitsuru Fujita; Takao Itoi

There are currently no plastic pancreatic duct stents that have been designed for endoscopic ultrasonography (EUS)-guided placement. This study prospectively evaluated the feasibility and efficacy of a new, single-pigtail, plastic stent. Eight patients with main pancreatic duct stricture or stenotic pancreatojejunostomy underwent EUS-guided placement of the pancreatic duct stent. The stent was placed successfully in all cases (8/8). Treatment success was achieved in all cases (8/8). A mild adverse event associated with the procedure was observed in one patient but there were no other adverse events during a mean follow-up of 7.4 months. This new pancreatic duct stent appears to be feasible and effective for EUS-guided stenting.


Journal of Hepato-biliary-pancreatic Sciences | 2016

New digital cholangiopancreatoscopy for diagnosis and therapy of pancreaticobiliary diseases (with videos)

Reina Tanaka; Takao Itoi; Mitsusyoshi Honjo; Takayoshi Tsuchiya; Toshio Kurihara; Shujiro Tsuji; Ryosuke Tonozuka; Kentato Kamada; Atsushi Sofuni; Shuntaro Mukai

Background and Objectives: Endoscopic ultrasonography (EUS)-guided transluminal drainage for pancreatic fluid collections (PFCs) has become the standard therapy worldwide as a minimally invasive therapy compared with surgical drainage. Recently, a novel flared-type biflanged metal stent (BFMS) designed specifically for the treatment of PFCs has been developed. The aim of this study was to retrospectively assess the feasibility and safety of EUS-guided drainage and direct endoscopic necrosectomy (DEN) for PFCs using the novel flared-type BFMS. Patients and Methods: Twenty-one patients were treated by EUS-guided drainage using a flared-type BFMS for PFCs (pancreatic pseudocyst, 2 patients; walled-off necrosis, 19 patients). Results: The present study showed a technical success rate of 100%, a final clinical success rate of 100%, a procedure-related adverse event (AE) rate of 0%, an early AE rate of 28.6% (moderate and severe AE rate of 9.5%), a mortality rate of 0%, and a recurrence rate of 9.5%. DEN (mean, 2.3 sessions) was required in 38% of the patients. Conclusion: The present study clarified that the EUS-guided drainage using the flared-type BFMS is an effective and safe treatment approach for PFCs. Further studies using randomized controlled multicenter trials are warranted.


Journal of Gastroenterology and Hepatology | 2013

Is the double‐guidewire technique superior to the pancreatic duct guidewire technique in cases of pancreatic duct opacification?

Reina Tanaka; Takao Itoi; Atsushi Sofuni; Fumihide Itokawa; Toshio Kurihara; Takayoshi Tsuchiya; Shujiro Tsuji; Kentaro Ishii; Nobuhito Ikeuchi; Junko Umeda; Ryosuke Tonozuka; Mitsuyoshi Honjo; Shuntaro Mukai; Fuminori Moriyasu

AIM To evaluate the safety and clinical application of high-intensity focused ultrasound (HIFU) therapy for unresectable pancreatic cancer (PC). METHODS Thirty PC patients (16 cases in stage III and 14 cases in stage IV) with visualized pancreatic tumors were admitted for HIFU therapy as an optional local therapy in addition to systemic chemotherapy or chemoradiotherapy. Informed consent was obtained. This study began at the end of 2008 and was approved by the ethics committee of our hospital [Institutional Review Board (IRB): 890]. The HIFU device used was the FEP-BY02 (Yuande Bio-Medical Engineering, Beijing, China). RESULTS The mean tumor size after HIFU therapy changed to 30.9 ± 1.7 mm from 31.7 ± 1.7 mm at pre-therapy. There were no significant changes in tumor size, mean number of treatment sessions (2.7 ± 0.1 mm), or mean total treatment time (2.4 ± 0.1 h). The rate of symptom relief effect was 66.7%. The effectiveness of primary lesion treatment was as follows: complete response, 0; partial response, 4; stable disease, 22; progressive disease, 4. Treatment after HIFU therapy included 2 operations, 24 chemotherapy treatments, and 4 best supportive care treatments. Adverse events occurred in 10% of cases, namely pseudocyst formation in 2 cases and mild pancreatitis development in 1. However, no severe adverse events occurred in this study. CONCLUSION We suggest that HIFU therapy is safe and has the potential to be a new method of combination therapy for PC.


Digestive Endoscopy | 2016

Endoscopic ultrasonography‐guided rendezvous technique

Takayoshi Tsuchiya; Takao Itoi; Atsushi Sofuni; Ryosuke Tonozuka; Shuntaro Mukai

Recently, a new digital cholangiopancreatoscopy (DCPS) has been developed. The aim of this study is to retrospectively evaluate the utility of new DCPS in patients with pancreaticobiliary diseases.


Journal of Hepato-biliary-pancreatic Sciences | 2014

Interventional endoscopy for the treatment of pancreatic pseudocyst and walled-off necrosis (with videos)

Shuntaro Mukai; Takao Itoi; Fuminori Moriyasu

Pancreatic duct guidewire placement (P‐GW) techniques include both the injection cannulation technique with a contrast medium and wire‐guided cannulation without contrast injection for selective biliary cannulation; the latter is the so‐called “double‐guidewire technique” (D‐GW). The aim of this study was to compare the outcomes between P‐GW and D‐GW for biliary cannulation.

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Atsushi Sofuni

Tokyo Medical University

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Reina Tanaka

Tokyo Medical University

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Shujiro Tsuji

Tokyo Medical University

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