Shyam Aravamudhan

Dispersion, Characterization and Uptake of Multi-Walled Carbon Nanotubes by Epithelial Cells

Multi-walled Carbon Nanotubes (MWCNTs) have a great potential for microelectronics, optics and in biomedical applications (e.g. as nanoelectrodes for neural stimulation and functional scaffolds for tissue engineering). In order to understand the interactions of MWCNTs with the human body on a whole, it is important to know how they interact with the cells. In this study, we dispersed the MWCNTs with anionic surfactant, characterized the properties of dispersed MWCNTs, and then evaluated the uptake of MWCNTs by A549 lung epithelial cells using Confocal Raman spectroscopy.

Non-invasive evaluation of cardiac repolarization in mice exposed to single-wall carbon nanotubes and ceria nanoparticles via intratracheal instillation

We present results obtained from electrocardiogram (ECG) measurements performed on mice exposed to single-walled carbon nanotubes and ceria nanoparticles through instillation. From these non-invasive ECG measurements, QT and RR intervals were obtained at various times after exposure and used to compute a novel metric for evaluating cardiac signal propagation stability, the reserve of refractoriness (RoR). It is demonstrated that while the isolated QT and RR intervals are essentially uncorrelated with histological data from hematoxylin and eosin stains of control and exposed tissue samples, the RoR is sensitive to cardiovascular effects from the exposure to nanoparticles.