Network
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Publication
Featured researches published by Sibylle Müller.
Journal of Medicinal Chemistry | 2008
Maksims Vanejevs; Claudia Jatzke; Steffen Renner; Sibylle Müller; Mirko Hechenberger; Tanja Bauer; Anna Klochkova; Ilya Pyatkin; Denis N. Kazyulkin; Elena Aksenova; Sergey Shulepin; Olga Timonina; Ariane Haasis; Aleksandrs Gutcaits; Chris G. Parsons; Valerjans Kauss; Tanja Weil
A discriminating pharmacophore model for noncompetitive metabotropic glutamate receptor antagonists of subtype 1 (mGluR1) was developed that facilitated the discovery of moderately active mGluR1 antagonists. One scaffold was selected for the design of several focused libraries where different substitution patterns were introduced. This approach facilitated the discovery of potent mGluR1 antagonists, as well as positive and negative mGluR5 modulators, because both receptor subtypes share similar binding pockets. For mGluR1 antagonists, a homology model of the mGlu1 receptor was established, and a putative binding mode within the receptors transmembrane domain was visualized.
Archive | 2007
Wojciech Danysz; Andrzej Dekundy; Mirko Hechenberger; Markus Henrich; Claudia Jatzke; Jens Nagel; Christopher Graham Raphael Parsons; Tanja Weil; Sibylle Müller; Juris Fotins; Aleksandra Gutcaits; Ronalds Zemribo; Valerjans Kauss; Larisa Kaulina; Elina Erdmane
Archive | 2009
Markus Henrich; Tanja Weil; Sibylle Müller; Valerjans Kauss; Elina Erdmare; Ronalds Zemribo
Archive | 2011
Ulrich Abel; Mirko Hechenberger; Markus Henrich; Valerjans Kauss; Holger Kubas; Udo Meyer; Sibylle Müller; Ronalds Zemribo
Archive | 2010
Markus Henrich; Tanja Weil; Mirko Hechenberger; Sibylle Müller; Valerjans Kauss; Ronalds Zemribo; Elina Erdmane; Gints Smits
Archive | 2009
Markus Henrich; Tanja Weil; Jens Nagel; Andreas Gravius; Sibylle Müller; Valerjans Kauss; Ronalds Zemribo; Juris Fotins
Archive | 2009
Markus Henrich; Tanja Weil; Sibylle Müller; Jens Nagel; Andreas Gravius; Valerjans Kauss; Ronalds Zemribo; Elina Erdmane
Archive | 2009
Markus Henrich; Tanja Weil; Sibylle Müller; Valerjans Kauss; Elina Erdmare; Ronalds Zemribo
publication.editionName | 2008
Mirko Hechenberger; Claudia Jatzke; Valerjans Kauss; Sibylle Müller; Christopher Graham Raphael Parsons; Gints Smits; Tanja Weil; Ronalds Zemribo; Elīna Erdmane
Archive | 2007
Wojciech Danysz; Andrzej Dekundy; Mirko Hechenberger; Markus Henrich; Claudia Jatzke; Jens Nagel; Christopher Graham Raphael Parsons; Tanja Weil; Sibylle Müller; Juris Fotins; Aleksandra Gutcaits; Ronalds Zemribo; Valerjans Kauss; Larisa Kaulina; Elina Erdmane
Collaboration
Dive into the Sibylle Müller's collaboration.
