Sigefumi Fujimura

A Therapeutic Approach to Roentgenographically Occult Squamous Cell Carcinoma of the Lung

The significance of limited resections, including wedge resection and segmentectomy, remains controversial because of their curability rates. In the current study, the objective was to determine a strategy for the treatment of patients with roentgenographically occult bronchogenic squamous cell carcinoma (ROSCC) based on the pathologic findings from 184 patients with ROSCC who underwent resection.

Clotrimazole, an imidazole antimycotic, is a potent inhibitor of angiogenesis.

Clotrimazole, an imidazole antimycotic, interferes with the rise in cytosolic Ca2+ and inhibits cell proliferation in a reversible manner. Here we describe the effect of clotrimazole on vascular endothelial cells (ECs). Clotrimazole inhibited the proliferation of ECs stimulated with typical angiogenic growth factors; vascular endothelial growth factor and basic fibroblast growth factor (bFGF). This inhibitory effect of clotrimazole was dose‐dependent and the maximal inhibition was observed at a concentration of 10 mM. We did not observe any increase in 51Cr release from ECs during treatment with 10 μM. clotrimazole. Moreover, clotrimazole inhibited the basal and bFGF‐stimulated migration of ECs. As clotrimazole inhibited two principle components of angiogenesis; the proliferation and migration of ECs, we examined whether clotrimazole inhibited angiogenesis. Tube formation by ECs in type 1 collagen gel was investigated, and clotrimazole was found to be significantly inhibitory. The inhibitory effect of clotrimazole on angiogenesis was further confirmed in an in vivo angiogenesis model of murine Matrigel plug assay. These results demonstrate that clotrimazole is a potent inhibitor of angiogenesis.

Comparison of resected and non-resected cases of roentgenographically occult bronchogenic squamous cell carcinoma.

118例の胸部X線写真無所見の扁平上皮癌のうち, 94例を切除し, 16例が上皮内癌であった. 76例は早期扁平上皮癌で, すべて再発転移は認めず, うち10例は亜区域支ないしその末梢にあった. リンパ節転移は6例あり, うち5例は腫瘍の浸潤が気管支壁を越えた症例であった.多発癌は, 切除標本の検索で初めて診断された6例を含めて20例 (16.9%) において観察された. 術死も含めた全死因でみた5生率は, 切除例で80.4%, 非切除例で45.0%であった.