Silje Odegaard

A randomized trial of the capability of elderly lay persons to perform chest compression only CPR versus standard 30:2 CPR

AIM OF THE STUDY Early cardiopulmonary resuscitation (CPR) improves survival after cardiac arrest, but there is a discrepancy between the age group normally attending CPR-classes and the age group most likely to witness a cardiac arrest. We wanted to study if elderly lay persons could perform 10min of CPR on a realistic manikin with continuous chest compressions (CCC) and conventional CPR (30:2). METHODS Volunteers were tested 5-7 months after CPR-classes. They were randomized to CCC or 30:2, and to receive feedback (FB) or not. Quality of CPR, age adjusted maximum heart rate (HRmax), and subjective exhaustion ratings were measured and evaluated in a blinded fashion. Temporal development and group differences were evaluated with ANOVA procedures. RESULTS All 64 volunteers were able to perform CPR for 10min and rated their efforts as mild to moderate in concordance with a mean HRmax of 78%. Quality of CPR was similar in all groups, except for chest compression rate that was slightly higher and had less variability in the FB group. Overall chest compression depth was 41+/-4.5mm. Analysis of temporal development of chest compression depth revealed a small initial decline before leveling off. As expected, CCC group had less pauses and higher total number of chests compressions. CONCLUSION Lay people in the age group 50-76 were able to perform CPR with acceptable quality for 10min and we found only very slight temporal quality deterioration. This makes training programs for the elderly meaningful to improve survival after cardiac arrest.

A randomized trial on elderly laypersons' CPR performance in a realistic cardiac arrest simulation

Bystander cardiopulmonary resuscitation (CPR) is important for survival after cardiac arrest. We hypothesized that elderly laypersons would perform CPR poorer in a realistic cardiac arrest simulation, compared to a traditional test.

Time used for ventilation in two-rescuer CPR with a bag-valve-mask device during out-of-hospital cardiac arrest

INTRODUCTION Professional rescuers only deliver chest compressions 39% of the available time before intubation during out-of-hospital cardiac arrest. In manikin-studies lay rescuers need approximately 15s to deliver two ventilations. It is not known how much time professional rescuers use for two ventilations and we hypothesised that the time used for two ventilations with a bag-valve-mask device before tracheal intubation is longer than recommended and that the extended time contributes to the high no flow time. METHODS Quality of CPR was available for analysis in 628 cases of out-of-hospital cardiac arrest in the ambulance service in Oslo, Akershus, London, and Stockholm from 2002 to 2005. The 2000 Guidelines were used as the reference. Ventilations were registered from changes in transthoracic impedance as measured through the standard defibrillation pads. We included episodes only with CPR with a 15:2 pattern for at least 1 min and identified all pauses between chest compressions before intubation. RESULTS In the remaining 172 episodes we identified 3097 chest compression pauses. In 1587 (51%) of the pauses we identified two ventilations and a mean pause length for each episode was calculated. The median of these means was 5.5s (IQR; 4.5, 7). These pauses comprised a median 9% (IQR; 4%, 15%) of the time before intubation in these episodes. In 892 (29%) of the pauses we identified a different number of ventilations, or other interventions in addition to ventilation. In the remaining 618 pauses (20%) no ventilations were registered. CONCLUSIONS Professional rescuers delivered two bag-valve-mask ventilations within the 5-6s as indicated in the 2000 Guidelines, slightly longer than the 3-4s recommended in the 2005 Guidelines. However, only half the pauses were used for two ventilations, and the total time for two ventilations accounted for only 27% of the time without chest compressions. Excessive time for ventilation cannot explain the high no-flow time during CPR by professional rescuers before intubation.

Incidence of Newborn Stabilization and Resuscitation Measures and Guideline Compliance during the First Minutes of Life in Norway

Background: Most newborns manage the transition from intra- to extrauterine life without interventions, yet neonatal morbidity caused by failure of transition remains an important health problem. Objective: To determine the incidence of neonatal stabilization and resuscitation measures and guideline compliance during the first minutes after birth. Methods: This is a prospective, observational study of all births in three Norwegian hospitals. All interventions performed, including suctioning, use of pulse oximetry, continuous positive airway pressure (CPAP), positive pressure ventilation (PPV), supplemental oxygen, intubation, and administration of drugs, were registered at every on-call team shift during the study period. Results: A total of 1,507 live-born infants were included, of whom 264 (18%) were brought to the resuscitation crib. Oropharyngeal suctioning was performed in 77 (5%), deep blind suctioning was carried out in 10 (1%) and 84 (6%) were monitored using pulse oximetry. PPV was provided in 58 cases (4%) - 8 (21%) of <34 weeks and 50 (3%) of ≥34 weeks of gestation. Sustained inflation is not routinely used in these departments. CPAP (without PPV) was provided in 17 cases (1%) - 4 (0.3%) were intubated and ventilated through the endotracheal tube. Supplemental oxygen was given to 39 infants (3%) - 9 without pulse oximetry monitoring. The median (interquartile range) birth weight and gestational age of the newborns requiring PPV and/or CPAP were 3,220 g (2,643-3,858) and 39 weeks (37-41), respectively. Conclusion: In this study, the need for resuscitation and/or stabilization measures was commonly considered, and 4% of all newborns received PPV. Despite strong guideline emphasis on the use of pulse oximetry to guide oxygen administration, many infants received oxygen treatment without pulse oximetry monitoring.

A combination of metabolic strategies plus cardiopulmonary bypass improves short-term resuscitation from prolonged lethal cardiac arrest.

BACKGROUND The metabolic or late phase of cardiac arrest is highly lethal. Emergency cardiopulmonary bypass (ECPB) can resuscitate many patients even after prolonged cardiac arrest and provides immediate vascular access for correction of metabolic derangement during the reperfusion process. We developed a rodent model of ECPB resuscitation which showed the superiority of ECPB over conventional CPR, especially when combined with hypothermia. For this study we examined a metabolic strategy against ischemia-reperfusion injury (MS-IR) that included: leukoreduction, low Ca(2+), Mg(2+), buffered pH, red blood cells and a colloid. We tested whether ECPB plus MS-IR and/or hypothermia improves short-term hemodynamic outcomes compared to a standard ECPB reperfusate. METHODS Using a 2×2 factorial design we tested ECPB with (a) MS-IR versus a standard crystalloid solution; and (b) hypothermia versus normothermia in our rat model. The four reperfusion strategies included: (1) MS-IR plus hypothermia, (2) MS-IR with normothermia, (3) standard plasma-lyte (STD) reperfusate plus hypothermia, or (4) STD plus normothermia. Animals underwent 12 min of untreated asphyxial arrest and were resuscitated with ECPB and one of the four strategies for 30 min. Thereafter, ECPB was discontinued and ventilatory support was provided for 3 hours, while hemodynamic, perfusion and other metrics were serially measured. RESULTS All rats achieved ROSC with ECPB. Significant differences between the groups emerged after 3 hrs: the best outcomes were in animals with MS-IR plus hypothermia (lactate: 1.1 ± 0.1 mmol/L; MAP: 83 ± 4 mm Hg, seizures: 0/10), while the worst outcomes were with STD and normothermia (lactate: 8.9 ± 1.4 mmol/L, MAP: 36 ± 4 mm Hg, seizures: 7/10, p < 0.001). The outcomes of the other two groups (MS-IR only; hypothermia only) were intermediate. MS-IR and hypothermia improved outcome in an additive fashion. CONCLUSIONS While most human ECPB is applied with a normothermic crystalloid priming solution, we observed that in rodents the addition of MS-IR plus hypothermia resulted in considerable short-term benefit after prolonged arrest. Future long-term and translational survival studies are warranted to optimize ECPB resuscitation methods.