Silvia G. Goijman

Constant and variable regions in DNA mini-circles from Trypanosoma cruzi and Trypanosoma rangeli: application to species and stock differentiation.

Abstract We have performed restriction endonuclease digestion of kinetoplast DNA mini-circles to characterize different stocks of two South American trypanosomes, Trypanosoma cruzi and Trypanosoma rangeli . The use of two fine cutter restriction enzymes (BspRI and MspI) that split the mini-circles in their variable region makes differentiation possible between all the parasites studied. Another restriction enzyme (TaqI) split the mini-circles to give a band with one-quarter of their molecular weight, which was the same in all stocks and clones from the two species studied, thus confirming the close relationship between T. cruzi and T. rangeli .

Effects of isoxazolyl-naphthoquinoneimines on growth and oxygen radical production in Trypanosoma cruzi and Crithidia fasciculata.

Several 4-(aminomethylisoxazolyl)-1,2-naphthoquinones inhibited growth and DNA synthesis inTrypanosoma cruzi and stimulated O2 uptake and

Effects of nitroheterocyclic drugs on macromolecule synthesis and degradation in Trypanosoma cruzi

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Pituitary response to luteinizing hormone-releasing hormone during haloperidol-induced hyperprolactinemia

generation by the parasite epimastigotes and their mitochondrial and microsomal membranes; these results support the idea that oxygen radicals play a role in quinone toxicity. Maximal effects on respiration and

Effect of Cycloheximide on the LH Release Induced by a Superactive Analog of LH-RH

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Nifurtimox and benznidazole inhibit DNA and protein synthesis in rat hepatocytes

generation were observed with antimycin-inhibited cells. Similar results as well as stimulation of H2O2 production were obtained withCrithidia fasciculata despite the presence of catalase in this organism.