Silvia G. Priori

Guías de práctica clínica sobre diabetes, prediabetes y enfermedades cardiovasculares

Preámbulo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Introducción . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Definición, clasificación y cribado de las alteraciones diabéticas y prediabéticas de la glucosa . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Epidemiología de la diabetes, alteraciones en el metabolismo de la homeostasis de la glucosa y riesgo cardiovascular . . . . . . . . . . . . . . . . . . . 8 Identificación de sujetos con alto riesgo de enfermedad cardiovascular o diabetes . . . . 12 Tratamiento para la reducción del riesgo cardiovascular . . . . . . . . . . . . . . . . . . . . . . . . . 15 Tratamiento de la enfermedad cardiovascular . . . 26 Insuficiencia cardiaca y diabetes . . . . . . . . . . . . . 34 Arritmias: fibrilación auricular y muerte súbita . . 36 Enfermedad periférica y cerebrovascular . . . . . . 40 Cuidados intensivos . . . . . . . . . . . . . . . . . . . . . . . 43 Economía sanitaria y diabetes . . . . . . . . . . . . . . . . 45 Bibliografía . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46 Guías de práctica clínica sobre diabetes, prediabetes y enfermedades cardiovasculares: versión resumida

Sudden Cardiac Death: A handbook for clinical practice

SECTION 1 EPIDEMIOLOGY AND MECHANISMS. 1 Epidemiology of cardiac arrest. Robert J. Myerburg and Hein J.J. Wellens. 2 Geneticpredisposition and pathology of sudden cardiacdeath. Xavier Jouven, Allen P. Burke, and Renu Virmani. 3 Arrhythmogenic mechanisms. Michiel J. Janse and Douglas P. Zipes. 4 Risk stratification for SCD. Stefan H. Hohnloser and Wojciech Zareba. 5 Autonomic nervous system: Emerging concepts and clinical. applications. Peter J. Schwartz and Richard L. Verrier. 6 Clinical characteristics of sudden cardiac death victims and. precipitating events. Christine M. Albert and Stuart M. Cobbe. SECTION 2 DISEASE STATES AND SPECIAL POPULATIONS. 7 Ischemic heart disease. William Wijns and Elliott M. Antman. 8 The cardiomyopathies. William J. McKenna, Srijita Sen-Chowdhry, and Barry J. Maron. 9 Inherited arrhythmogenicdiseases. Silvia G. Priori and Charles Antzelevitch. 10 Sudden cardiac death and valvular heart diseases. David Messika-Zeitoun, Bernard J. Gersh, Olivier Fondard, and Alec Vahanian. 11 Heart failure. William G. Stevenson and Helmut Drexler. 12 Drug-induced sudden death. Dan M. Roden and Milou-Daniel Drici. 13 Sudden death in athletes. Domenico Corrado, Cristina Basso, Mark S. Link, Gaetano Thiene, and. N.A. Mark Estes III. SECTION 3 TREATMENT. 14 Pharmacology of sudden cardiac death. Timothy W. Smith, Michael E. Cain, Gunter Breithardt, and. Paulus Kirchhof. 15 Implantable devices. A. John Camm and Arthur J. Moss. 16 Sudden cardiac death: ablation. Prashanthan Sanders, John M. Miller, Meleze Hocini,. Pierre Jais, and Michel Haissaguerre. 17 External automated defibrillators. M.A. Peberdy, K.A. Ellenbogen, and D.A. Chamberlain. 18 Cost-effectiveness of implantable cardioverter-defibrillators. Giuseppe Boriani and Greg Larsen. Index

Markovian model for wild-type and mutant (Y1795C and Y1795H) human cardiac Na/sup +/ channel

Long QT syndrome (LQTS) and Brugada syndrome (BrS) are inherited syndromes predisposing to ventricular arrhythmias and sudden death. Emerging evidences related LQTS and BrS to dysfunctions of cardiac ion channels. Recently, two novel missense mutations in gene encoding for the cardiac Na channel have been identified (Y1795C for LQTS and Y1795H for BrS). Both mutations alter inactivation, intermediate inactivation, onset of inactivation of Na current and cause a sustained Na current. In this study we present a Markovian model of wild type and mutant Na channels. Model includes three closed states, an open state, and five inactivated states. Transition rates between these states were identified on the basis of electrophysiological experiments. The model is able to reproduce the current alterations observed in mutant channels just by alter the transition rates with respect to wild type assignment.