Silvia Rigamonti
University of Milan
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Featured researches published by Silvia Rigamonti.
Human Molecular Genetics | 2018
Daniele Bottai; Marco Spreafico; Anna Pistocchi; Grazia Fazio; Raffaella Adami; Paolo Grazioli; Adriana Canu; Cinzia Bragato; Silvia Rigamonti; Chiara Parodi; Gianni Cazzaniga; Andrea Biondi; Franco Cotelli; Angelo Selicorni; Valentina Massa
Abstract Cornelia de Lange syndrome (CdLS), which is reported to affect ˜1 in 10 000 to 30 000 newborns, is a multisystem organ developmental disorder with relatively mild to severe effects. Among others, intellectual disability represents an important feature of this condition. CdLS can result from mutations in at least five genes: nipped‐B‐like protein, structural maintenance of chromosomes 1A, structural maintenance of chromosomes 3, RAD21 cohesin complex component and histone deacetylase 8 (HDAC8). It is believed that mutations in these genes cause CdLS by impairing the function of the cohesin complex (to which all the aforementioned genes contribute to the structure or function), disrupting gene regulation during critical stages of early development. Since intellectual disorder might result from alterations in neural development, in this work, we studied the role of Hdac8 gene in mouse neural stem cells (NSCs) and in vertebrate (Danio rerio) brain development by knockdown and chemical inhibition experiments. Underlying features of Hdac8 deficiency is an increased cell death in the developing neural tissues, either in mouse NSCs or in zebrafish embryos.
Social Science Research Network | 2001
Alberto Floreani; Silvia Rigamonti
Social Science Research Network | 2003
Massimo Belcredi; Stefano Bozzi; Silvia Rigamonti
Corporate Ownership and Control | 2008
Silvia Rigamonti
Social Science Research Network | 2000
Silvia Rigamonti; R. Barontini
Archive | 1999
Silvia Rigamonti; Alberto Floreani
Birth defects research | 2017
Grazia Fazio; Laura Rachele Bettini; Silvia Rigamonti; Dorela Meta; Andrea Biondi; Giovanni Cazzaniga; Angelo Selicorni; Valentina Massa
BANCARIA | 2014
Silvia Rigamonti; Lorenzo Caprio
BANCARIA | 2014
Lorenzo Caprio; Silvia Rigamonti
Archive | 2005
Silvia Rigamonti