Silvyo David Araújo Giffoni
State University of Campinas
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Featured researches published by Silvyo David Araújo Giffoni.
Arquivos De Neuro-psiquiatria | 2004
Silvyo David Araújo Giffoni; Vanda Maria Gimenes Gonçalves; Verônica A. Zanardi; Vera Lúcia Gil da Silva Lopes
Considering the rarity of the frontonasal dysplasia (FD) and the few reports about it in a large casuistry using magnetic resonance image (MRI), we describe the results of the angular analysis of the corpus callosum of 18 individuals with FD (7 male, 11 female), using an easily-reproductive method. Group I had 12 individuals with isolated form and Group II had 6 individuals with FD syndromic with unknown etiology. The results are presented in set. Comparing with the control group, patients with FD presented alpha angle increase and beta and gamma angles reduction (p<0.05). Alpha and gamma angles express the relationship between the anterior portion of corpus callosum and the floor of 4th ventricle. Considering the embryonary development, these findings would occur secondarily to failure during the development of nasal capsula. Thus, angular anomaly in corpus callosum would be a usual finding, and not fortuitous in patients with FD.
The Cleft Palate-Craniofacial Journal | 2006
Silvyo David Araújo Giffoni; Vanda Maria Gimenes Gonçalves; Verônica A. Zanardi; Vera Lúcia Gil-da-Silva-Lopes
Objective Twenty-four patients were evaluated to better characterize neurological and neuroradiological aspects of midline facial defects with ocular hypertelorism. Methods After a clinical genetics evaluation, the individuals were divided into two groups: 12 isolated cases (group 1) and 12 associated with multiple congenital anomalies (group 2). The investigation protocol included medical and family history, as well as dysmorphological, neurological, and neuroradiological evaluations by magnetic resonance imaging or computed tomography scan. Results Because there was no significant difference concerning the neurological aspects of groups 1 and 2, they were analyzed together. Mild hypotonia (24 of 24), abnormalities in cranial shape (24 of 24), cranial nerves (19 of 24), motor coordination (18 of 24), dynamic equilibrium (14 of 24), and language problems (8 of 24) were noted. Measurements of the posterior fossa showed hypoplastic cerebellar vermis (8 of 17), the cerebellum at lower normality limits (5 of 17), and signs of cerebellar hypoplasia (3 of 7). Conclusion This study clearly demonstrates the presence of structural and functional neurological abnormalities related to midline facial defects with ocular hypertelorism, as well as involvement of the cerebellum. It provides a basis for future investigation of midline facial defects with ocular hypertelorism and should be considered during planning of rehabilitation treatment.
The Cleft Palate-Craniofacial Journal | 2006
Silvyo David Araújo Giffoni; Fernando Cendes; Marcelo Valente; Vera Lúcia Gil-da-Silva-Lopes
We report on a child with midline facial defects with hypertelorism (MFDH), median cleft lip, sphenoidal ventriculocele, partial agenesis of the corpus callosum, and low-grade astrocytoma in the cervicomedullary junction. This combination of findings has not been reported previously. Although this association might be casual, it demonstrates a relationship between disorders of frontonasal process and posterior fossae. It also suggests that individuals with MFDH might require a prospective follow-up with central nervous system magnetic resonance imaging.
The Cleft Palate-Craniofacial Journal | 2009
Silvyo David Araújo Giffoni; Fernando Cendes; Marcelo Valente; Vera Lúcia Gil-da-Silva-Lopes
Objectives We studied the neuroimaging and neurophysiological aspects of 17 patients with midline facial defects with ocular hypertelorism (MFDH). Methods The investigation protocol included a previous semistructured questionnaire about family history; gestational, neonatal, and postnatal development; and dysmorphologic and neurologic evaluation. Recognized monogenic disorders and individuals with other well-known conditions were excluded. All patients had high resolution magnetic resonance imaging (MRI) with multiplanar reconstruction (MPR) and routine electroencephalograms (EEGs). Results We detected abnormalities in five patients whose MRIs had been previously reported as normal. MRI showed central nervous system (CNS) structural abnormalities in all patients, which included commissural alterations in 16/17 (94%), malformations of cortical development in 10/17 (58%), disturbances of neural tube closure in 7/17 (42%), and posterior fossa anomalies in 6/17 (35%). Some patients had more than one type of malformation occurring at different stages of the embryonary process. EEGs showed epileptiform activity in 4/17 (24%) and background abnormalities in 5/17 (29%) of patients. Conclusion This study clearly demonstrated the presence of structural and functional neurologic alterations related to MFDH. Therefore, the CNS anomalies cannot be considered incidental findings but an intrinsic part of this condition, which could be related to environmental effects and/or genetic mutations. These findings would provide a basis for future investigations on MFDH and should also be considered when planning rehabilitation.
International Journal of Current Advanced Research | 2018
Silvyo David Araújo Giffoni; Ana Cristina de Castro; Sylvia Maria Ciasca
Revista Psicopedagogia | 2017
Ana Cristina de Castro; Silvyo David Araújo Giffoni
Revista Psicopedagogia | 2017
Ana Cristina de Castro; Silvyo David Araújo Giffoni
Revista Psicopedagogia | 2017
Erlaine Chaves Machado Vieira; Silvyo David Araújo Giffoni
International Journal of Current Advanced Research | 2017
Ana Cristina de Castro; Unicamp. Address: Anchieta Ave; Cambui, Campinas, Sp. Brazil zip code; Silvyo David Araújo Giffoni
13th International Child Neurology Congress (ICNC2014) | 2014
Iuri Victor Capelatto; Sylvia Maria Ciasca; Silvyo David Araújo Giffoni; Cíntia Alves Salgado-Azoni