Simon Giroux

An Efficient, Stereocontrolled Synthesis of the 25-(R)-Diastereomer of Dafachronic Acid A from β-Ergosterol

A direct and stereocontrolled synthesis of the 25-(R)-diastereomer of dafachronic acid A from beta-ergosterol has been developed.

Syntheses and Biological Evaluation of B-Ring-Modified Analogues of Dafachronic Acid A

Synthesis and testing of dafachronic acid A ( 1) and its derivatives 2 and 3 have revealed that 1, and not a further oxidation product, is the natural ligand for the DAF-12 receptor of Caenorhabditis elegans.

A study of the epoxidation of cycloolefins by the t-BuOH copper-permanganate system.

Evidence is presented that Cu(MnO(4))(2) effectively epoxidizes trisubstituted steroid olefins by a nonconcerted pathway.

Enantioselective Synthesis of a Simple Benzenoid Analogue of Glycinoeclepin A

A synthesis of the readily accessible glycinoeclepin A analogue 2 is reported.