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Simon J. Coutts

Boehringer Ingelheim

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Featured researches published by Simon J. Coutts.

Tetrahedron Letters | 1994

Two efficient methods for the cleavage of pinanediol boronate esters yielding the free boronic acids

Simon J. Coutts; Julian Adams; Dale Krolikowski; Roger J. Snow

Abstract Two synthetic methods for the preparation of boronic acids from their corresponding pinanediol boronate esters are reported. The key to success of the procedures relies on removal of the liberated pinanediol from the reaction mixture.

Journal of Medicinal Chemistry | 1996

Structure−Activity Relationships of Boronic Acid Inhibitors of Dipeptidyl Peptidase IV. 1. Variation of the P2 Position of Xaa-boroPro Dipeptides

Simon J. Coutts; Terence A. Kelly; Roger J. Snow; Charles A. Kennedy; Randall W. Barton; Julian Adams; Dale Krolikowski; Dorothy M. Freeman; Scot Campbell; John Ksiazek; William W. Bachovchin

Journal of Medicinal Chemistry | 1997

Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity.

Edward S. Lazer; Clara K. Miao; Charles L. Cywin; Ronald John Sorcek; Hin-Chor Wong; Zhaoxing Meng; Ian Potocki; Maryann Hoermann; Roger J. Snow; Matt Aaron Tschantz; Terence A. Kelly; Daniel W. McNeil; Simon J. Coutts; Laurie Churchill; Anne G. Graham; Eva David; Peter M. Grob; Wolfhard Engel; Hans Meier; Gunter Trummlitz

Journal of the American Chemical Society | 1993

Immunosuppresive boronic acid dipeptides: correlation between conformation and activity

Terence A. Kelly; Julian Adams; William W. Bachovchin; Randall W. Barton; Scot Campbell; Simon J. Coutts; Charles A. Kennedy; Roger J. Snow

Archive | 1992

Method for making a prolineboronate ester

Roger J. Snow; Terence A. Kelly; Julian Adams; Simon J. Coutts; Clark Perry

Biochemistry | 1994

Solution structures of active and inactive forms of the DP IV (CD26) inhibitor Pro-boroPro determined by NMR spectroscopy.

James L. Sudmeier; Ulrich L. Günther; William G. Gutheil; Simon J. Coutts; Roger J. Snow; Randall W. Barton; William W. Bachovchin

Biochemistry | 1995

NON-SIALATE INHIBITOR OF INFLUENZA A/WSN/33 NEURAMINIDASE

Joe C. Wu; Gregory W. Peet; Simon J. Coutts; Robert J. Eckner; Johanna A. Griffin; Peter R. Farina

Magnetic Resonance in Chemistry | 1995

Solution structures of the DP IV (CD26) inhibitor Val‐boroPro determined by NMR spectroscopy

Ulrich L. Günther; James L. Sudmeier; Simon J. Coutts; Roger J. Snow; Randall W. Barton; William W. Bachovchin

Archive | 1994

Menetelmä proliiniboronaattiesterin valmistamiseksi

Roger J. Snow; Terence A. Kelly; Julian Adams; Simon J. Coutts; Clark Perry

Archive | 1994

Process for the preparation of proliiniboronaattiesterin

Roger J. Snow; Terence A. Kelly; Julian Adams; Simon J. Coutts; Clark Perry

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Roger J. Snow

Boehringer Ingelheim

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Julian Adams

Boehringer Ingelheim

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Terence A. Kelly

Boehringer Ingelheim

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Clark Perry

Boehringer Ingelheim

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Randall W. Barton

Boehringer Ingelheim

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William W. Bachovchin

Tufts University

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Charles A. Kennedy

Boehringer Ingelheim

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Dale Krolikowski

Boehringer Ingelheim

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Scot Campbell

Boehringer Ingelheim

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James L. Sudmeier

Tufts University

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