Sissel Erland Tomten

Slow postmeal walking reduces postprandial glycemia in middle-aged women

Postprandial blood glucose concentration is a risk factor for the development of cardiovascular diseases and diabetes, even at states well below hyperglycemic levels. A previous study has shown that postmeal exercise of moderate intensity blunts the blood glucose increase after carbohydrate intake (Høstmark et al. Prev. Med. 42(5): 369-371). The objective of the present study was to examine whether even postmeal slow walking would have a similar effect. Fourteen healthy women aged >50 years participated in 3 experiments in a random crossover design: after a carbohydrate-rich meal, either they were seated (control experiment) or they performed slow postmeal walking for 15 min (W15) or 40 min (W40). Blood glucose concentration was determined prior to the meal (fasting), and at 11 time points throughout each experiment. The W15 trial lowered the blood glucose values during walking and delayed the peak blood glucose value (p = 0.003). In W40, the postmeal blood glucose increase during walking was blunted, the peak glucose value was delayed (p = 0.001), and the incremental area under the 2-h blood glucose curve (IAUC) was reduced (p = 0.014). There was a negative relationship between IAUC and walking time (p = 0.016). The individual reducing effect of walking on IAUC correlated strongly with IAUC on the control day (p < 0.001). We conclude that even slow postmeal walking can reduce the blood glucose response to a carbohydrate-rich meal. The magnitude of this effect seems to be related to the duration of walking and to the magnitude of the postprandial blood glucose response when resting after a carbohydrate-rich meal.

Serum albumin and blood pressure: a population-based, cross-sectional study.

Background and purpose Information about the association between serum albumin and blood pressure is limited. The purpose of the present paper was to investigate this relationship in different age groups in males and females. Methods In the cross-sectional Norwegian Oslo Health Study, the concentration of serum albumin and blood pressure was determined in 5071 men and women 30–75 years of age. The albumin–blood pressure relationship was studied using multiple regression. Results In general, men had higher albumin values than women, and young subjects had higher albumin values than old. Within all age groups and in both sexes, systolic and diastolic blood pressure increased with increasing albumin concentration within the physiological range. An increase in the albumin concentration over the physiological range from approximately 40 to 50 g/l was associated with an increase in the systolic blood pressure between 5 and 11 mmHg in males, depending on age, and between 6 and 17 mmHg in females. Corresponding increases in diastolic blood pressure were between 3 and 7 mmHg in males, and 4 to 9 mmHg in females. Per one SD increment in the albumin concentration the blood pressure increase was 1–3 mmHg. Conclusion Within the different age groups, irrespective of sex and age, a positive association was found between serum albumin and blood pressure. Since albumin, in contrast to high blood pressure, is considered to be cardioprotective, the two variables probably affect cardiovascular risk by unrelated mechanisms.

Effects of different types of exercise on muscle mass, strength, function and well-being in elderly

Abstract Poor muscle strength and physical function have been associated with higher risk of hospitalisation and lower well-being among the elderly. Physical training increases muscle strength, endurance and physical function as well as psychological outcomes. Exercise among older adults is often used to improve these variables, but few have compared the effects of different types of training in parallel independent groups. Thus, the aim of the present study was to investigate the effect of three different types of training on body composition, muscle strength, physical function and well-being in the elderly. A total of 118 community-dwelling older adults (mean age 74.3, s=4.6 years, 68% women) completed a 13-week randomised controlled exercise-trial involving four groups: traditional strength training (STG), functional strength training (FTG), endurance training (ETG) and control (CON). Stair climb with load improved more in FTG than CON (P<0.05), and the two strength groups performed better in the functional upper body test (P<0.05). STG increased strength more than CON in all exercises (P<0.001), while FTG increased strength more than CON in the chest press, shoulder press and knee extension (P<0.05). Lean body mass (LBM) increased in all training groups, which differed significantly from CON (P<0.05). ETG decreased their fat mass compared to CON (P<0.001). The only significant effect on well-being indices was improved life satisfaction in FTG at week 5 (P<0.05). We also observed significant correlations between change in some of the functional tests and change in positive affect. All three types of training can enhance physical capacity. Functional strength training can be a cost effective form of training in terms of less demand for instructors and equipment and could be an effective way to improve physical function, strength and indices of well-being in the elderly.

The Oslo health study: cheese intake was negatively associated with the metabolic syndrome.

Objective: We previously reported that the frequency of cheese intake (FCI) was negatively associated with serum triglycerides and positively associated with high-density lipoprotein cholesterol (HDL), both components of the metabolic syndrome (MetS). We therefore wanted to study whether FCI is associated with MetS. Methods: The Oslo Health Study (18,770 subjects), obtained data from 7815 men and 9685 women on cheese intake and risk factors for MetS, except for fasting glucose. MetS requires central obesity and at least 2 of the following: increased triglycerides, low HDL cholesterol, increased systolic or diastolic blood pressure, and elevated fasting blood glucose. We calculated the index SumRisk, providing the number of MetS factors present, and MetSRisk to reflect the combined levels of many MetS factors. The association between FCI and MetSRisk (SumRisk) was studied using regression analyses. Results: In young (30 years), middle-aged (40 and 45 years), seniors (59–60), and old (75–76 years) subjects, there was an inverse association between FCI and MetSRisk (p ≤ 0.005, except in old men). Using regression, we found a consistent negative association (p < 0.001) between FCI and MetSRisk, SumRisk, single MetS components, and the complete MetS, prevailing after controlling for sex, age, time since last meal, intake of fruit/berries, fruit juice, fatty fish, coffee, alcohol, smoking, leisure time physical activity, years at school, and birthplace. FCI was also negatively associated with body mass index (p < 0.02), except in old women. Conclusion: Cheese intake can be negatively and independently associated with (1) an index including the level of many risk factors for MetS, (2) the number of MetS requirements present, (3) single MetS components, and (4) the complete MetS.

Cola intake and serum lipids in the Oslo Health Study

Soft drinks can be a major source of sucrose, which may influence serum lipid concentration. We have examined the association between intake frequency of various types of soft drinks and the concentration of serum triglycerides (TG) and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol in the cross-sectional Oslo Health Study. A total of 14 188 subjects of the altogether 18,770 participants of the study had data on intake frequency of colas and non-colas, with or without sugar. The population sample consisted of both sexes and 3 age groups: group 1 (30 years of age), group 2 (40 and 45 years of age), and group 3 (59-60 years of age). In both sexes, HDL decreased and TG increased significantly (p < 0.001) with increasing intake frequency of colas. In contrast, no consistent associations were found between the reported intake of non-cola soft drinks and the serum lipids. We found no significant differences related to the reported presence or absence of sugar in the soft drinks. In multiple linear regression analyses, the colas vs. serum lipid associations prevailed (p < 0.001) after including 13 possible confounders: sex; age group; time since last meal; physical activity; intake of alcohol, coffee, cheese, fruit and (or) berries, and fatty fish; smoking; length of education; use of cholesterol-lowering drugs; and intake of non-colas. Thus, the self-reported intake frequency of colas, but not other soft drinks, was negatively associated with serum HDL, and positively associated with TG and LDL.

Serum albumin and self-reported prevalence of stroke: a population-based, cross-sectional study

Background Since information about the association between serum albumin and risk of stroke is limited the purpose of the present paper was to re-investigate this relationship. Design The study followed a cross-sectional design. Methods In the cross-sectional Norwegian Oslo Health Study the concentration of serum albumin and blood pressure was determined in a random sample of 5071 men and women, 30-75 years of age. Logistic regression was used to study the association between the serum albumin concentration and self-reported prevalence of stroke. In the sample there were 122 subjects with a history of stroke and 4949 subjects without. Results Low albumin (i.e. ≥ 47 versus >47 g/l) was associated with increased prevalence of self-reported stroke (odds ratio 1.83; 95% confidence interval, 1.20-2.78; P=0.005), after adjusting for age (≥ 45 versus ≥ 59 years) and sex. Including smoking, blood pressure and length of education into the model did not have any major influence on the result. Conclusion Low serum albumin is associated with increased prevalence of self-reported stroke.