Siva Senthil Kumar Boominathan

Palladium(0)-catalyzed single and double isonitrile insertion: a facile synthesis of benzofurans, indoles, and isatins.

A palladium(0)-catalyzed cascade process consisting of isonitrile insertion and α-Csp(3)-H cross-coupling can be achieved for the synthesis of benzofurans and indoles. The construction of isatins by a Pd-catalyzed cascade reaction incorporating double isonitrile insertion, amination, and hydrolysis has also been achieved. The key features of this work include diverse heterocycle synthesis, phosphine-ligand-free reaction conditions, a one-pot procedure, simple and commercially available starting materials, broad functional-group compatibility, and moderate to good reaction yields.

An Iron‐Catalyzed Cascade Approach to Benzo[b]carbazole Synthesis Followed by 1,4‐Sulfonyl Migration

A simple and straightforward approach was developed to construct 5H-benzo[b]carbazole derivatives by iron catalysis in a cascade sequence. The notable features of this work include an atom-economical cascade sequence, unprecedented 1,4-sulfonyl migration, tolerance of a variety of functional groups, good yields, and an economical catalytic system.

A Palladium‐ and Copper‐Catalyzed Synthesis of Dihydro[1,2‐b]indenoindole‐9‐ol and Benzofuro[3,2‐b]indolines: Metal‐Controlled Intramolecular CC and CO Bond‐Forming Reactions

A palladium- and copper-catalyzed synthesis of dihydro[1,2-b]indenoindole-9-ol and benzofuro[3,2-b]indolines has been developed, whereby the same starting material is employed for the synthesis of both heterocyclic scaffolds and the selectivity of the product is controlled by switching the choice of metal. Salient features of these cascade reactions include wide-ranging functional group tolerance, simple reaction conditions, and moderate to high yields.

A sequential one-pot approach to 1,2,4,5-tetrasubstituted-2H-imidazole synthesis from disubstituted alkynes

A sequential one-pot approach to the tetrasubstituted 2H-imidazole scaffolds has been developed from disubstituted alkynes and structurally diverse ketones. The reaction proceeds via a diketo intermediate generated from internal alkynes followed by the addition of ammonium acetate and a suitable ketone, affording a diverse range of 2H-imidazoles. Using air-moisture stable reaction conditions and inexpensive reagents, the transformation demonstrates a broad substrate scope and good functional group compatibility.

Copper-catalyzed one-pot process to construct triazole-linked urea derivatives

ABSTRACT A new one-pot synthetic methodology has been developed to construct the triazole-linked urea derivatives. In the same step, triazole forms from azide and alkyne via click reaction and urea forms from addition reaction of amines and isocyanates. The notable features of this work include wide substrate scope, atom economy, environmental friendliness, and easily accessible starting materials. The preliminary biological screening of synthesized compounds show promising cytotoxic activity in basal cell carcinoma (BCC) cell lines. GRAPHICAL ABSTRACT