Sivaperuman Saravanan

Synthesis of Highly Substituted 2,3-Dihydro-1H-pyrrole Derivatives via a Tandem Regioselective Addition of Nitrones to 1,3-Enynes with Subsequent Rearrangement

A novel method for the synthesis of 1,3-enynes is described through oxidative cyclization of the semicarbazones of Michael adducts having potential nitrile functionality. Reaction of these 1,3-enynes with diaryl nitrones has yielded a diastereomeric mixture of highly substituted 2,3-dihydro-1H-pyrrole derivatives via a tandem regioselective addition with subsequent rearrangement.

SYNTHESIS AND SPECTRAL CHARACTERIZATION OF DIETHYL 2-[ARYL(4-ARYL-1,2,3-SELENADIAZOL-5-YL)METHYL]MALONATE

Synthesis and characterization of several diethyl 2-[aryl(4-aryl-1,2,3-selenadiazol-5-yl)methyl]malonates are reported.

Synthesis and characterization of 1,2,3-selena/thiadiazoles linked to other heterocyclic units

Synthesis of novel 1,2,3-selena/thiadiazoles, linked to different benzo-1,3-heteroazole ring by sulfur has been reported. Structural features of the compounds have been analyzed by 1H and 13C NMR, mass and single crystal X-ray studies.

Chemoselective Addition of Hydrazine to δ‐Keto Esters and Dimethylformamide‐Mediated Deesterification

Abstract The chemoselective reaction of hydrazine on the ketone rather than the ester in a gem diester system with a γ‐keto group by hydrazinium sulfate and a tandem deesterification of one of the esters in this system by N,N‐dimethylformamide are reported.

Formation of reagent-selective products from 2-(4,5-dihydrothi- azol-2-ylthio)-1-arylethanone with different nucleophiles

The reactions of 2-(4,5-dihydrothiazol-2-ylthio)-1-arylethanone with different nucleophiles including semicarbazide hydrochloride, hydroxylamine hydrochloride, hydrazine, ethylenediamine and aminoethanol have been investigated, and the formation of a variety of products with different reagents is highlighted.

Tandem ring opening and oximation of ethyl 3 -aroyl -1 -cyano -4 -hydroxy -2,4,6-triarylcyclohexanecarboxylate by hydroxylamine

Abstract The reaction of hydroxylamine hydrochloride with ethyl 3‐aroyl‐1‐cyano‐4‐hydroxy‐2,4,6‐triarylcyclohexanecarboxylate has led to the formation of ethyl 2‐[amino(hydroxyimino)methyl]‐3‐aryl‐5‐(hydroxyimino)‐5‐arylpentanoate via a tandem ring opening and oximation process. The structures of the products are confirmed by NMR and X‐ray techniques, and the conformational features of the product arrived at are compared with a molecular dynamics simulation study.