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Siya Ram

Cubist Pharmaceuticals

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Publication

Featured researches published by Siya Ram.

Bioorganic & Medicinal Chemistry Letters | 2003

Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors.

John T. Finn; Karen Mattia; Mike Morytko; Siya Ram; Yingfei Yang; Ximao Wu; Elsa Mak; Paul Gallant; Dennis Keith

Starting with a micromolar lead identified from high-throughput screening, a series of pyrazoles were discovered with significantly improved potency on bacterial methionyl-tRNA synthetase and selectivity over human methionyl-tRNA synthetase.

Archive | 2001

Inhibitors of inflammation and reperfusion injury and methods of use thereof

Prakash Jagtap; Garry J. Southan; Andrew L. Salzman; Csaba Szabo; Siya Ram

Bioorganic & Medicinal Chemistry Letters | 2004

The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1)

Prakash Jagtap; Garry J. Southan; Erkan Baloglu; Siya Ram; Jon G. Mabley; Anita Marton; Andrew L. Salzman; Csaba Szabó

Archive | 2002

5-aryltetrazole compounds, compositions thereof, and uses therefor

Alex Nivorozhkin; John H. Van Duzer; Andrew L. Salzman; Garry J. Southan; Siya Ram; Qi Zeng; Csaba Szabo

Archive | 2002

Nucleoside compounds and compositions thereof

Prakash Jagtap; Garry J. Southan; Andrew L. Salzman; Csaba Szabo; Siya Ram

Archive | 2001

7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof

Prakash Jagtap; Garry J. Southan; Andrew L. Salzman; Csaba Szabo; Siya Ram

Archive | 2003

Aryltetrazole compounds, and compositions thereof

Alexander Nivorozhkin; John H. Van Duzer; Garry J. Southan; Siya Ram; Qi Zeng

Archive | 2005

5-Aryltetrazole compounds and uses thereof

Alex Nivorozhkin; John H. Van Duzer; Andrew L. Salzman; Garry J. Southan; Siya Ram; Qi Zeng; Csaba Szabo

Archive | 2005

5-Aryltetrazoles compounds and compositions thereof

Alex Nivorozhkin; John H. Van Duzer; Garry J. Southan; Siya Ram; Qi Zeng

Archive | 2001

Agents inhibiteurs d'inflammation et de lesion par perfusions repetees ; methode d'utilisation

Prakash Japtap; Garry J. Southan; Andrew L. Salzman; Csaba Szabo; Siya Ram

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Collaboration

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Garry J. Southan

St Bartholomew's Hospital

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Andrew L. Salzman

Cincinnati Children's Hospital Medical Center

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Csaba Szabo

Cincinnati Children's Hospital Medical Center

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Prakash Jagtap

Brigham and Women's Hospital

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John H. Van Duzer

Novartis

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Dennis Keith

Merck

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Csaba Szabó

University of Texas Medical Branch

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Elsa Mak

Cubist Pharmaceuticals

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Erkan Baloglu

Virginia Tech

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John T. Finn

University of Massachusetts Amherst

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