Slađana B. Novaković

Synthesis and crystal structure of trans-dichloro(1,3-propylenediamine-n,n′-diacetato)platinum(IV) monohydrate

The trans-geometrical isomer of the first Pt(IV) complex with the tetradentate ligand 1,3-propylenediamine-N,N′-diacetate ion (pdda) was prepared by a direct synthesis from potassium hexachloroplatinate(IV) and pdda in the presence of lithium hydroxide. The crystal structure of trans-[Pt(pdda)Cl2]·H2O complex has been determined. The Pt(IV) ion has a distorted octahedral coordination due to intramolecular N–H···Cl interactions.

Ferrocenyl chalcones with O-alkylated vanillins: synthesis, spectral characterization, microbiological evaluation, and single-crystal X-ray analysis

O-alkylated vanillin derivatives 2a–f and acetylferrocene react under Claisen–Schmidt conditions, resulting in good-to-high yields of the corresponding ferrocene chalcones 3a–f. None of the resultant compounds 3b–f has been previously described in the literature. All synthesized compounds were characterized by spectral and physical data, whereas two of them, 1-ferrocenyl-3-(4-ethoxy-3-methoxyphenyl)-prop-2-en-1-one (3b) and 1-ferrocenyl-3-(4-buthoxy-3-methoxy-phenyl)-prop-2-en-1-one (3e), were crystalline substances, suitable for single-crystal X-ray analysis, which confirmed undoubtedly their structures. Chalcones 3a–f were tested for their biological activity and demonstrated relatively good in vitro antimicrobial activity towards different strains of bacteria and fungi. The best antibacterial activity is expressed by compounds 3b and 3c, while compound 3d shows the best antifungal activity.

SYNTHESIS AND CRYSTAL STRUCTURE OF s-cis-(ETHYLENEDIAMINE-N,N′-DIACETATO)COBALT(III) COMPLEX WITH N,N-DIMETHYLGLYCINE

ABSTRACT The s-cis-geometrical isomer of the cobalt(III) complex with N,N-dimethylglycine (dmgly) and the tetradentate ligand ethylenediamine-N,N′-diacetate ion (edda) was prepared by a direct synthesis from cobalt(II) chloride hexahydrate, N,N-dimethylglycine and edda in the presence of lead(IV) oxide. The complex has been isolated chromatographically and characterized by elemental analyses, electron absorption spectra, infrared spectra and X-ray diffraction analysis.

Cytotoxic and Antimicrobial Activity of Dehydrozingerone based Cyclopropyl Derivatives

A small series of 1‐acetyl‐2‐(4‐alkoxy‐3‐methoxyphenyl)cyclopropanes was prepared, starting from dehydrozingerone (4‐(4‐hydroxy‐3‐methoxyphenyl)‐3‐buten‐2‐one) and its O‐alkyl derivatives. Their microbiological activities toward some strains of bacteria and fungi were tested, as well as their in vitro cytotoxic activity against some cancer cell lines (HeLa, LS174 and A549). All synthesized compounds showed significant antimicrobial activity and expressed cytotoxic activity against tested carcinoma cell lines, but they showed no significant influence on normal cell line (MRC5). Butyl derivative is the most active on HeLa cells (IC50 = 8.63 μm), while benzyl one is active against LS174 and A549 cell lines (IC50 = 10.17 and 12.15 μm, respectively).

Synthesis and crystal structure of [Co(L)(NO2)3]H2O (L = piridoxylene Girar-T hydrazone)

Dark red monocrystals of title complex were prepared by the reaction of water solutions of Na3[Co(NO2)6] and L×2H2O in mole ratio 1:1. The Co(III) is sited in an octahedral environment. The equatorial plane is formed by a tridentate coordination of the ligand (L) and one NO2 molecule, while the other two NO2 molecules are in axial positions. The ligand is coordinated to the Co(III) atom through O3, N1 and O4 atoms, forming two fused chelate rings, one being five-membered and one a six-membered one. All atoms in the chelate and phenyl rings are approximately coplanar. The angle between the mean plan of the equatorial NO2 and the mean plane defined by the two chelate rings is 28.1(3)°. The Co-N bond lengths for the two axial NO2 are about 0.03 Å longer than that with the equatorial NO2. The two axial NO2 are coplanar. The complex molecule possesses eight oxygen atoms capable of acting as proton acceptors in the hydrogen bonds, but there are only two groups (one N-H and one O-H) able to participate as proton donors. As a consequence, six oxygen atoms from NO2 ligands form weak C-H...O hydrogen bonds with only one exception for O4 atom which participates in two strong O-H...O hydrogen bonds. Because of that the N-O4 bond is significantly longer than the rest of N-O bonds in the NO2 ligands. Data were collected on an Enraf-Nonius CAD-4 diffractometer using Mo K radiation ( = 0.71069 Å) and /2 scans in 1.41 to 25.47° range and were corrected for Lorentz and polarization effects. The structure was solved by direct methods and difference-Fourier methods, and refined by full matrix least-squares using SHELXL97 program to a final R = 0.0431 for 2938 reflections with I > 2 I. Crystallographic data: CoC13H22N7O10, Mr = 495.3, monoclinic, space group P 21/c, a = 14.936(3) Å, b = 7.773(3) Å, c = 17.463(3)Å, = 104.26(3) °, V = 1964.9(9) Å, Z = 4, Dc = 1.674 Mg/m , (MoK ) = 0.944 mm, Mo K radiation, = 0.71073 A, GooF = 1.055.