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Featured researches published by So Wong.


Drug Delivery | 2009

Peptide-mediated targeting of hepatocytes via low density lipoprotein receptor-related protein (LRP).

James J. Ludtke; Alex V. Sokoloff; So Wong; Guofeng Zhang; Dudley K. Strickland; Jon A. Wolff

It has previously been reported that a peptide sequence of T7 phage protein p17 mediates uptake of its cargo by liver parenchymal cells. The aim of this study was to identify the phage-binding receptor. The involvement of LRP was confirmed by the observations that phage binding to Hepa 1c1c7 cells was inhibited by the LRP-binding receptor-associated protein, LRP-deficient mouse embryonic fibroblasts bound phage with lower efficiency than their wild-type counterparts, and using mouse models with ablated LRP liver expression. The identification of LRP as a cognate receptor for this sequence offers a new ligand-receptor combination for hepatocyte delivery of therapeutic agents.


Archive | 2007

Polyconjugates for in vivo delivery of polynucleotides

David B. Rozema; Darren H. Wakefield; Jason Klein; So Wong; Jon A. Wolff; David L. Lewis; James E. Hagstrom; Andrei Blokhin; Vladimir Trubetskoy; Hans Herweijer


Archive | 2003

Compounds for targeting hepatocytes in vivo

Alexander V. Sokoloff; So Wong; Jon A. Wolff; Sean D. Monahan; James J. Ludtke; Lori Higgs; Darren H. Wakefield; Magdolna G. Sebestyén


Archive | 2005

Formation of polyampholytes in the presence of a polyion

Darren H. Wakefield; David B. Rozema; Jon A. Wolff; Vladimir S. Trubetskoy; James E. Hagstrom; Vladimir G. Budker; Jason Klein; So Wong


Archive | 2014

Polyconjugates for delivery of RNAi triggers to tumor cells in vivo

Weijun Cheng; So Wong; Aaron Almeida; David B. Rozema; Andrei V. Blokhin; Jeffrey C. Carlson


Archive | 2016

COMPOSITIONS AND METHODS FOR INHIBITING GENE EXPRESSION OF HIF2ALPHA

So Wong; David L. Lewis; David B. Rozema; Darren H. Wakefield; Weijun Chen; Lauren Almeida; Andrei V. Blokhin; Jeffrey C. Carlson; Anthony L. Nicholas; Aaron Almeida; Steven B. Kanner; Jonathan D. Benson; Justin Woods


Cancer Research | 2016

Abstract 2064: Novel HIF-2α targeted RNAi therapeutic for renal cell carcinoma

So Wong; Weijun Cheng; Darren H. Wakefield; Aaron Almeida; Andrei V. Blokhin; Holly Hamilton; Vladimir Subbotin; Julia Hegge; Zane C. Neal; Guofeng Zhang; David B. Rozema; David B. Lewis; Steven B. Kanner


Archive | 2013

Polyconjugate for in vivo delivery of polynucleotide

David B. Rozema; デイヴィッド ビー. ロゼマ; Darren H. Wakefield; ダレン エイチ. ウェイクフィールド; Jon A. Wolff; ジョン エイ. ウォルフ; So Wong; ソー ウォン; Jason Klein; ジェーソン クライン; David L. Lewis; デイヴィッド エル. ルイス; James E. Hagstrom; ジェイムズ イー. ハグストローム; Andrei V. Blokhin; アンドレイ ブロヒン; Vladimir S. Trubetskoy; ウラジーミル トルベツコイ; Hans Herweijer; ハンス ハーヴェイジェル


Journal of Pharmacological and Toxicological Methods | 2009

Enabling targeted siRNA delivery in vivo using dynamic polyconjugate technology

David B. Rozema; David L. Lewis; Darren H. Wakefield; So Wong; Jason Klein; Holly Hamilton; Jessica Vera; Stephanie L. Bertin; Tom W. Reppen; Qili Chu; Vladimir Trubetskoy; Andrei V. Blokhin; James E. Hagstrom; Jon A. Wolff


Archive | 2007

Polykonjugate zur in-vivo-verabreichung von polynukleotiden

Andrei V. Blokhin; James E. Hagstrom; Hans Herweijer; Jason Klein; David L. Lewis; David B. Rozema; Vladimir S. Trubetskoy; Darren H. Wakefield; Jon A. Wolff; So Wong

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David B. Rozema

University of Wisconsin-Madison

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Jon A. Wolff

University of Wisconsin-Madison

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David L. Lewis

Howard Hughes Medical Institute

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Hans Herweijer

University of Wisconsin-Madison

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