Sofiane Ennifar
Nabi Biopharmaceuticals
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Featured researches published by Sofiane Ennifar.
Pharmacology, Biochemistry and Behavior | 2000
Paul R. Pentel; David H. Malin; Sofiane Ennifar; Yoko Hieda; Dan E. Keyler; J.Ronald Lake; Judit R Milstein; Lisa Basham; R.Todd Coy; J.William D Moon; Robert Naso; Ali Fattom
Vaccination of animals to elicit drug-specific antibodies, or the passive transfer of such antibodies from other animals, can reduce the behavioral effects of drugs such as cocaine and heroin. To study the potential application of this approach to treating nicotine dependence, IgG was isolated from rabbits immunized with a nicotine-protein conjugate vaccine. Anesthetized rats received immune IgG containing nicotine-specific antibodies (Nic-IgG) or control-IgG i.v.. Thirty minutes later, rats received nicotine at 0.03 mg/kg i.v., equivalent on an mg/kg basis to the nicotine intake from two cigarettes by a smoker. Compared to control-IgG, Nic-IgG reduced the brain nicotine concentration in a dose-related manner (65% reduction at the highest IgG dose). Pretreatment with Nic-IgG also reduced the distribution to brain of five repeated doses of nicotine (equivalent to the nicotine intake from 10 cigarettes) administered over 80 min. To study blood pressure effects, rats received control-IgG or Nic-IgG 1 day prior to administering nicotine. Nicotine-induced systolic blood pressure increases were attenuated by Nic-IgG in a dose-related manner, and were almost completely blocked by the highest Nic-IgG dose. Pretreatment with Nic-IgG also completely prevented the nicotine-induced stimulation of locomotor activity observed in rats receiving control-IgG. Nic-IgG did not prevent locomotor activation from cocaine, demonstrating its specificity for nicotine. These data demonstrate that the administration of nicotine-specific antibodies can reduce or prevent some of the pharmacokinetic, cardiovascular, and behavioral consequences of nicotine in rats. Effects were observed at nicotine doses and nicotine serum concentrations equal to or exceeding those typically associated with nicotine exposure in cigarette smokers. A potential role for immunization in the treatment of nicotine dependence is suggested.
Life Sciences | 2002
David H. Malin; Candice L Alvarado; Katherine S Woodhouse; Hilary Karp; Evelyn Urdiales; Diana Lay; Phillipa Appleby; William D. Moon; Sofiane Ennifar; Lisa Basham; Ali Fattom
Ten rats were trained in a two lever operant chamber to press different levers after a nicotine injection (0.14 mg/kg s.c.) or a saline injection on an FR10 schedule. The rats were then injected i.p. with either 150 mg nicotine-specific IgG or the same amount of control IgG from non-immunized rabbits. On successive days, they were retested with both levers active after a saline injection, a full training dose of nicotine and a half dose of nicotine (0.07 mg/kg s.c.). After saline injection, both groups pressed the saline lever almost exclusively. After each of the nicotine doses, the immunized rats performed a significantly lower percentage of their lever presses on the nicotine lever than did non-immunized rats. The results suggest that passive immunization can interfere with the stimulus properties of nicotine.
Infection and Immunity | 1998
Ali Fattom; Jawad Sarwar; Lisa Basham; Sofiane Ennifar; Robert Naso
Archive | 1999
Sofiane Ennifar; Ali Fattom; Robert Naso
Pharmacology, Biochemistry and Behavior | 2001
David H. Malin; J.Ronald Lake; Andy Lin; Michael Saldaña; Laura Balch; M.L.Laredo Irvin; Hishara Chandrasekara; Candice L Alvarado; Yoko Hieda; Dan Keyler; Paul R. Pentel; Sofiane Ennifar; Lisa Basham; Robert Naso; Ali Fattom
Archive | 2006
Ali Fattom; Jawad Sarwar; Zuzana Kossaczka; Kimberly L. Taylor; Sofiane Ennifar
Nicotine & Tobacco Research | 2010
David H. Malin; William D. Moon; Pilar Goyarzu; Nancy Magallanes; Michelle B. Blair; Melodee R. Alexander; Lauren McDavid; Jason L. Spurgeon; Sofiane Ennifar; Ali Fattom
Archive | 2006
Sofiane Ennifar
Archive | 2006
Ali Fattom; Zuzana Kossaczka; Kimberly L. Taylor; Sofiane Ennifar; Jawad Sarwar
Archive | 1999
Ali Fattom; Robert Naso; Sofiane Ennifar