Soheyla D. Gharib
Harvard University
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Featured researches published by Soheyla D. Gharib.
The New England Journal of Medicine | 1994
Peter J. Neumann; Soheyla D. Gharib; Milton C. Weinstein
BACKGROUND The use of in vitro fertilization has engendered considerable debate about who should have the procedure, whether health insurance should cover the cost, and if so, to what extent. We investigated the cost of a successful delivery with in vitro fertilization. METHODS We calculated the cost per successful delivery with in vitro fertilization (defined as at least one live birth) for a general population of couples undergoing in vitro fertilization and for two subgroups: couples with a diagnosis of tubal disease (who have a better chance of success), and couples in which the woman is over the age of 40 years and the man has a low sperm count (who have a lower chance of success). Information on charges per cycle of in vitro fertilization was obtained from six facilities across the country; delivery rates with this procedure were estimated from the literature. RESULTS On average, the cost incurred per successful delivery with in vitro fertilization increases from
Journal of Clinical Investigation | 1987
Soheyla D. Gharib; Margaret E. Wierman; Thomas M. Badger; William W. Chin
66,667 for the first cycle of in vitro fertilization to
Journal of Clinical Investigation | 1986
Soheyla D. Gharib; S M Bowers; L R Need; William W. Chin
114,286 by the sixth cycle. The cost increases because with each cycle in which fertilization fails, the probability that a subsequent effort will be successful declines. Sensitivity analyses indicated that the cost per delivery ranges from
Journal of General Internal Medicine | 2001
David G. Fairchild; Karen Sax McLoughlin; Soheyla D. Gharib; Jan Horsky; Michelle Portnow; James M. Richter; Nancy J. Gagliano; David W. Bates
44,000 to
Advances in Experimental Medicine and Biology | 1986
William W. Chin; Soheyla D. Gharib
211,940. For couples with a better chance of successful in vitro fertilization (i.e., those with a diagnosis of tubal disease), it costs
The New England Journal of Medicine | 2015
Soheyla D. Gharib; David H. Berger; Garry Choy; Amelia E. Huck
50,000 per delivery for the first cycle and
Archive | 2015
Soheyla D. Gharib; David H. Berger; Garry Choy; Amelia E. Huck
72,727 for the sixth. For couples in which the woman is older and there is a diagnosis of male-factor infertility, the cost rises from
bioRxiv | 2018
Shirlee Wohl; Hayden C. Metsky; Stephen F. Schaffner; Anne Piantadosi; Meagan Burns; Joseph A. Lewnard; Bridget Chak; Lydia A Krasilnikova; Katherine J Siddle; Christian B. Matranga; Bettina Bankamp; Scott Hennigan; Brandon Sabina; Elizabeth H. Byrne; Rebecca J. McNall; Daniel J. Park; Soheyla D. Gharib; Susan Fitzgerald; Paul Barriera; Stephen Fleming; Susan M. Lett; Paul A. Rota; Lawrence C. Madoff; Bronwyn MacInnis; Nathan L. Yozwiak; Sandra Smole; Yonatan H. Grad; Pardis C. Sabeti
160,000 for the first cycle to
Archive | 1988
William W. Chin; Soheyla D. Gharib; Margaret E. Wierman
800,000 for the sixth. CONCLUSIONS The debate about insurance coverage for in vitro fertilization must take into account ethical judgments and social values. But analyses of costs and cost effectiveness help elucidate the economic implications of using in vitro fertilization and thus inform the policy discussion.
Archive | 1986
William W. Chin; Soheyla D. Gharib
Follicle-stimulating hormone (FSH) beta, luteinizing hormone (LH) beta, and alpha subunit messenger RNA (mRNA) levels were examined in rats after castration and sex-steroid replacement. Subunit mRNAs were determined by blot hybridization using rat FSH beta genomic DNA, and alpha and LH beta complementary DNA (cDNA). Rat FSH beta mRNA is 1.7 kilobase in size. After ovariectomy, female FSH beta mRNA levels increased fourfold, whereas those of LH beta and alpha increased twenty- and eightfold, respectively. With estradiol, all subunits returned toward normal levels. Male LH beta and alpha mRNA levels rose eight- and fourfold, respectively, 40 d postcastration, but FSH beta mRNA levels increased minimally. After 7 d of testosterone propionate, LH beta and alpha mRNAs declined to normal levels, whereas FSH beta mRNA increased slightly. We conclude that in female rats FSH beta is negatively regulated by gonadal steroids, but to a lesser extent than LH beta or alpha mRNAs, and there is a differential regulation of FSH beta mRNA levels in males as compared with females at the time points examined.