Soleh Kosela

Lateriflorone, a cytotoxic spiroxalactone with a novel skeleton, from Garcinia lateriflora BL

Abstract Lateriflorone ( 1 ), a cytotoxic natural product with an unprecedented spiroxalactone skeleton isolated from Garcinia lateriflora , has been characterized by NMR and X-ray crystallography studies as 6,21-bis(3-methylbut-2-enyl)-19-hydroxy-2,2,23,23-tetramethyl-13,15,22-trioxaspiro[6,7-dihydro-2H-chromene-7,4′-tetracyclo[7.4.1.0 2,7 .0 2,11 ] tetradecane]-17-ene-5,8,16,20-tetraone.

The structure of Lansioside A : A novel triterpene glycoside with amino-sugar from lansium domesticum

Abstract Lansioside A, a novel triterpene amino-sugar glycoside, is isolated from Lansium domesticum and its full structure including absolute configuration is established by the chemical derivation and spectral study.

Secomultiflorane-type triterpenoid acids from stem bark of Sandoricum koetjape

Abstract Bryononic acid and two new ring-A secotriterpenoids were isolated from Sandoricum koetjape stem bark and their structures elucidated by NMR spectrometry.

Dulxanthone E: a pyranoxanthone from the leaves of Garcinia dulcis

A pyranoxanthone, dulxanthone E isolated from Garcina dulcis, was elucidated as 5,9,10,12-tetramethoxy-2,2-dimethyl-2H-pyrano[5,6-b]xanthen-6-one by various NMR techniques and confirmed by X-ray crystallography.

PC31 EFFECTS OF DITERPENE ACIDS ON MALONDIALDEHYDE GENERATION DURING THROMBIN INDUCED AGGREGATION OF RAT PLATELETS

The effects of diterpene acids (i.e, pimaradienoic acid, kaurenoic acid, hydroxycembratrienoic acid and dihydroxycembratetraenoic acid) on malondialdehyde generation by rat platelets in response to thrombin were studied. All the compounds inhibited the generation of MDA.

(+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees

One new alkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1), together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl)lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC50 value of 3.9 μg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS.

A novel polyisoprenyl benzophenone derivative from Garcinia eugeniaefolia

A novel polyisoprenyl benzophenone derivative named eugeniaphenone (1) was isolated from the stem bark of Garcinia eugeniaefolia Wall. Its structure was elucidated by spectroscopic methods, including 1D and 2D NMR techniques, and confirmed by single-crystal X-ray diffraction analysis. It is the first example in which an isoprenyl unit formed a cyclobutane-containing side chain in the polyisoprenyl benzophenone derivatives.

A new cytotoxic xanthone from Garcinia rigida.

A new xanthone, yahyaxanthone (1), was isolated from Garcinia rigida leaves. Cytotoxicity evaluation showed that 1 was inhibitory to L1210 cell, with an IC50 value 4.08 microg/ml.

A new benzophenone from the stem bark of Garcinia benthami

From the stem bark of Garcinia benthami a new benzophenone, named Salimbenzophenone, was isolated. The structure was determined by means of spectroscopic analysis.

Two new xanthons from Garcinia rigida leaves

Two new xanthons, musaxanthone (1) and asmaxanthone (2) were isolated from the leaves of Garcinia rigida. The structures were determined by means of spectroscopic analysis.