Solomon Estren

Coexistent Pernicious Anemia and Malabsorption in Four Patients: Including One Whose Malabsorption Disappeared with Vitamin B12 Therapy

Excerpt Evaluation of patients with megaloblastic anemia due to vitamin B12deficiency includes absorption studies using radioactive labeled vitamin B12and intrinsic factor. These studies are perfor...

Lymphoblastic-like Leukemic Transformation of Polycythemia Vera

Excerpt Polycythemia vera terminates in acute leukemia in 0 to 30% of cases, depending on the series cited (1). The nature of this leukemic transformation has not been well characterized but is gen...

MALABSORPTION SYNDROME: INTESTINAL ABSORPTION OF VITAMIN B12

Excerpt The common denominator of the clinical entities variously known as non-tropical sprue, tropical sprue, celiac disease and idiopathic steatorrhea is impaired intestinal absorption of various...

Treatment of pernicious anemia by oral administration of vitamin B12 without added intrinsic factor.

PERNICIOUS anemia is generally considered to be a heredofamilial disease in which a lack of intrinsic factor is associated with atrophy of the gastric mucosa. As the disease develops, intrinsicfact...

Pernicious anemia. I. Remission by small oral doses of purified vitamin B12.

Summary 1. Hematologic and clinical remissions were induced 11 times in 8 patients with pernicious anemia in relapse, and in 1 patient with non-pernicious megaloblastic anemia, by small oral doses of purified vit. B12 without added intrinsic factor. The effective dosage range was 5 to 16.8 μg per day. 2. Unequivocal failure occurred in 1 case of relapsed pernicious anemia. 3. These results further confirm the suggestion that in pernicious anemia there is a quantitative rather than a qualitative change in gastric secretion, and that variations in the amounts of intrinsic factor remaining in pernicious anemia patients may be responsible for varying responses to oral vit. B12. 4. A trial period of vit. B12 alone should precede any study with a vit. B12 plus intrinsic factor preparation.

The Use of Animal AHG-Concentrates in Patients with Circulating Anticoagulants.

Excerpt The patient with hemophilia and a circulating anticoagulant often represents a grave medical emergency not responsive to therapy with fresh frozen plasma, since the anticoagulant blocks the...

Alteration of plasma clearance of vitamin B12 by intravenous hog intrinsic factor concentrate.

Summary 1. Studies of the fate of intravenously injected vitamin B12 bound to hog intrinsic factor concentrate have been performed in patients with pernicious anemia and malabsorption syndrome. 2. The abnormal plasma disappearance curves of vit B12 in pernicious anemia and malabsorption syndrome became normal after incubation of B12 with hog intrinsic factor concentrate. 3. Plasma clearance of radioactivity in pernicious anemia is slower following injection of intrinsic factor labeled with I131 than following injection of intrinsic factor labeled with radiocobalt-B12. 4. A specific effect of intrinsic factor in transferring circulating vit B12 to the liver is discussed.