Songül Özyurt

Copeptin: a new predictor for severe obstructive sleep apnea.

Introduction Copeptin which is the C-terminal fragment of antidiuretic hormone (ADH), is a biomarker that has been reported to be increased in various cardiovascular disorders, cerebrovascular diseases and associated with prognosis. Patients with obstructive sleep apnea syndrome (OSAS) have a tendency to develop coronary and cerebral atherosclerotic diseases. Objectives The aim of the present study was to study copeptin levels in patients with obstructive sleep apnea and in a control group in order to determine whether copeptin could be used as a biomarker predicting the severity of OSAS and possible complications in this group. Methods A total of 116 patients with OSAS, diagnosed by polysomnography, and 27 controls were included in the study. Blood samples were collected after overnight fasting, and copeptin levels were measured with enzyme-linked immunosorbent assay. Results Copeptin levels were significantly higher in the OSAS group compared to control group (2,156±502; 1,845±500 pg/mL, respectively, P=0.004). Mean copeptin level of the patients having apnea-hypopnea index (AHI) ≥30 was significantly higher than that of the patients having AHI <30 (2,392±415; 2,017±500 pg/mL, respectively, P<0.001). A multivariate regression analysis showed that copeptin level, (hazard ratio: 1.58; 95% confidence interval: 1.09–2.30) was a predictor of severe OSAS (P=0.016). Copeptin levels showed significant positive correlation with AHI (r=0.32; P<0.001), desaturation index (r=0.23; P=0.012), arousal index (r=0.24; P=0.010) and CRP (r=0.26; P=0.011) respectively. Conclusion Copeptin levels are high in OSAS patients and copeptin is a potential marker for identifying patients with a high risk of early cardiovascular complications of OSAS. Copeptin has modest sensitivity (84%) for discriminating severe OSAS patients who are candidates for severe cardiovascular complications.

CHANGING CLINICAL CHARACTERISTICS OF PULMONARY THROMBOEMBOLISM IN THE ELDERLY

YAŞLI HASTALARDA PULMONERTROMBOEMBOLİNİN DEĞİŞEN KLİNİK KARAKTERLER

Syncope as a subject of the risk assessment of pulmonary thromboembolism to be used for: A cross-sectional study

Syncope is infrequent in pulmonary thromboembolism (PTE) yet might be indicative of haemodynamic instability. The prognostic role of syncope in PTE has not been well documented.

Mounier-kuhn syndrome: a case report.

Mounier-Kuhn syndrome is a rare clinical and radiologic entity characterized by the pathologic dilatation of the trachea and bronchi. The clinical features consist of expiratory central airway collapse, airflow limitation, and clinical presentation similar to chronic bronchitis. A 73-year-old man was admitted to the hospital with the complaints of cough, sputum, dyspnea, and recurrent bronchitis. The radiologic, spirometric, and bronchoscopic findings showed the Mounier-Kuhn syndrome. We describe characteristic bronchoscopic and spirometric features of the Mounier-Kuhn syndrome.