Songyang Lv

1,2,3-Triazole-assisted C–H amidation by cobalt(III) catalysis

A procedure for the [Cp*CoIII]-catalyzed, 1,2,3-triazole directed C–H amidation of arenes, using dioxazolone as an efficient amidating reagent, has been developed. This reaction provides a step- and atom-economical protocol for C–N bond formation, releasing carbon dioxide as a single byproduct. Yet a variety of functional groups are well tolerated, obtaining the desired products in moderate to excellent yields.

Synthesis of isatins by the palladium-catalyzed intramolecular acylation of unactivated aryl C(sp2)–H bonds

Synthesis of isatins from formyl-N-arylformamides is achieved via PdCl2-catalyzed intramolecular acylation. This method shows the possibility of Pd-catalyzed aryl C(sp2)–H bond activation on the synthesis of isatins, affording an array of isatins in good yields. Yet this protocol is operationally simple and atom economical.

Synthesis of CHF2-substituted 3-azabicyclo[3.1.0]hexanes by photochemical decomposition of CHF2-pyrazolines

A practical synthesis of CHF2-substituted 3-azabicyclo[3.1.0]hexanes was developed for the first time. The key step was photochemical decomposition of CHF2-substituted pyrazolines. This protocol has the advantages of simple operation, and mild conditions, as well as excellent functional group tolerance, giving the desired products in moderate to excellent yields.

Rhodium-Catalyzed Direct C-H Bond Cyanation in Ionic Liquids

A Cp*Rh(III)/IL-based direct C-H bond cyanation system was developed for the first time. The system is a mild, efficient, and recyclable method for the synthesis of aryl nitriles. Many different directing groups can be used in this cyanation, and the reaction tolerates a variety of functional groups.

[Cp*RhIII]/Ionic Liquid as a Highly Efficient and Recyclable Catalytic Medium for C−H Amidation

A [Cp*RhIII ]-catalyzed direct C-H amidation is carried out in ionic liquid. Both C(sp2 )-H bonds of (hetero)arenes and alkenes and unactivated C(sp3 )-H bonds can be easily amidated with high functional-group tolerance and excellent yields under these conditions. Notably, using [Cp*RhIII ]/[BMIM]BF4 (BMIM=1-butyl-3-methylimidazolium) as the green and recyclable medium is environmentally benign, in light of characteristics such as the reusability of the expensive rhodium catalyst, avoidance of highly toxic organic solvents, and mild reaction conditions, as well as a short reaction time.