Sonia Bory

Resolution of γ-methyl and γ-fluoroglutamic acids. Lack of stereospecificity of leucine aminopeptidase with L-leucyl-L-erthro-γ-substituted glutamates

The hydrolysis of L-leucyl-γ-substituted D,L-glutamates by leucine aminopeptidase, from porcine kidney, is stereospecific with erythro-γ-methyl and erytho-γ-fluoroglutamate containing dipeptides whereas there is a lack of stereospecificity with the erytho-isomers. The optical purities of L-threo- and L-erythro-glutamate isomers thus obtained have been monitored by gas chromatography, high pressure liquid chromatography, or nuclear magnetic resonance. The optical rotations of optically pure L-isomers have been measured and the discrepancies with former publications are discussed.

STEREOCHEMIE UND MECHANISMUS DER HALOGENIERUNG VON CYCLISCHEN SULFOXIDEN

Bei der Chlorierung der cyclischen Sulfoxide (Ia) bzw. (IVa) entstehen jeweils die gleichen Produkte (IIa) bzw. (IIIa), unabhangig von der sterischen Anordnung am S-Atom.