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Featured researches published by Sonia S. Hassan.


Virchows Archiv | 2013

Changes of placental syndecan-1 expression in preeclampsia and HELLP syndrome

Szilvia Szabo; Yi Xu; Roberto Romero; Tibor Füle; Katalin Karászi; Gaurav Bhatti; Tibor Várkonyi; Ildiko Varkonyi; Tibor Krenács; Zhong Dong; Adi L. Tarca; Tinnakorn Chaiworapongsa; Sonia S. Hassan; Zoltán Papp; Ilona Kovalszky; Nandor Gabor Than

Preeclampsia is characterized by maternal systemic anti-angiogenic and pro-inflammatory states. Syndecan-1 is a cell surface proteoglycan expressed by the syncytiotrophoblast, which plays an important role in angiogenesis and resolution of inflammation. Our aim was to examine placental syndecan-1 expression in preeclampsia with or without hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. Placentas were obtained from women in the following groups: (1) late-onset preeclampsia (nu2009=u20098); (2) early-onset preeclampsia without (nu2009=u20097) and (3) with HELLP syndrome (nu2009=u20098); (4) preterm controls (nu2009=u20095); and (5) term controls (nu2009=u20099). Tissue microarrays (TMAs) were constructed from paraffin-embedded placentas. TMA slides were immunostained for syndecan-1 and evaluated using microscopy, virtual microscopy, and semi-automated image analysis. Maternal sera from patients with preeclampsia (nu2009=u200949) and controls (nu2009=u200932) were immunoassayed for syndecan-1. BeWo cells were treated with Forskolin or Latrunculin B or kept in ischemic conditions. SDC1 expression and syndecan-1 production were investigated with qRT-PCR, confocal microscopy, and immunoassays. Syndecan-1 was localized to the syncytiotrophoblast apical membrane in normal placentas. Syndecan-1 immunoscores were higher in late-onset preeclampsia (pu2009=u20090.0001) and early-onset preeclampsia with or without HELLP syndrome (pu2009=u20090.02 for both) than in controls. Maternal serum syndecan-1 concentration was lower in preeclampsia (median, 673xa0ng/ml; interquartile range, 459–1,161xa0ng/ml) than in controls (1,158xa0ng/ml; 622–1,480xa0ng/ml). SDC1 expression and syndecan-1 immunostainings in BeWo cells and syndecan-1 concentrations in supernatants increased during cell differentiation. Disruption of the actin cytoskeleton with Latrunculin B decreased syndecan-1 release, while ischemic conditions increased it. Syncytiotrophoblastic syndecan-1 expression depends on the differentiation of villous trophoblasts, and trophoblastic syndecan-1 release is decreased in preeclampsia and HELLP syndrome. This phenomenon may be related to the disturbed syncytiotrophoblastic cortical actin cytoskeleton and associated with maternal anti-angiogenic and pro-inflammatory states in these syndromes.


American Journal of Reproductive Immunology | 2017

CXCL10 and IL‐6: Markers of two different forms of intra‐amniotic inflammation in preterm labor

Roberto Romero; Piya Chaemsaithong; Noppadol Chaiyasit; Nikolina Docheva; Zhong Dong; Chong Jai Kim; Yeon Mee Kim; Jung-Sun Kim; Faisal Qureshi; Suzanne M. Jacques; Bo Hyun Yoon; Tinnakorn Chaiworapongsa; Lami Yeo; Sonia S. Hassan; Offer Erez; Steven Korzeniewski

To determine whether amniotic fluid (AF) CXCL10 concentration is associated with histologic chronic chorioamnionitis in patients with preterm labor (PTL) and preterm prelabor rupture of the membranes (PROM).


Ultrasound in Obstetrics & Gynecology | 2007

OC144: Clinical significance of the presence of amniotic fluid ‘sludge’ in patients with cervical cerclage

Juan Pedro Kusanovic; Roberto Romero; Jimmy Espinoza; L. F. Gonçalves; Francesca Gotsch; Natalia Camacho; W. Lee; Offer Erez; M. L. Schoen; Sonia S. Hassan

to 30 + 0) weeks + days in the TPTL group. Mean (SD) cervical length was similar in the control (36.1 (2.9) mm) and PPROM (36.6 (16.6) mm) groups, but shorter in the TPTL group (20.4 (9.2) mm; P = 0.01). Mean (SD) FMBV was lower in controls (9.4 (6.4)%) than in the PPROM (21.2 (10.0)%) and TPTL (18.9 (6.9)%) groups (P = 0.01). The median time between the first examination and delivery was 2 (range, 1–4) weeks in the PPROM group and 4 (range, 1–14) weeks in the TPTL group. In PPROM, 7/10 cases delivered within the 2 weeks after the first examination, and 6/7 had a FMBV above 18% in spite of a cervical length within normal values. In TPTL, there was a significant association between the cervical length and the time to delivery (r = 51, P = 0.001), but in most cases FMBV was similarly increased. Conclusions: In TPTL the cervical length correlated well with the time to delivery and FMBV did not improve this information. However, in PPROM an increment in FMBV appears to be independently associated with an earlier delivery.


Medical Imaging 2018: Ultrasonic Imaging and Tomography | 2018

Ultrasound, elasticity, and photoacoustic imaging of cervix: towards a more accurate prediction of preterm delivery (Conference Presentation)

Yan Yan; Jiayin Dong; Adeel A. Siddiqu; Yashashree Majalikar; Maryam Basij; Edgar Hernandez-Andrade; Sonia S. Hassan; Mohammad Mehrmohammadi

Spontaneous preterm birth (sPTB) occurs in about one in ten infants born in the United States and is leading to almost 1 million neonatal deaths worldwide [1]. Diagnostic imaging of cervix is mostly limited to using ultrasound (US) to measure cervical length and has shown a low specificity to determine the risk of sPTB [2-7]. Quantitative functional imaging modalities such as elastography (EL) and photoacoustic (PA) imaging, are commonly used in conjunction with US imaging to provide additional information on tissue compositions and function. We propose using an endocavity probe to acquire US, PA, and EL information of the cervical tissue. Specifically, spectroscopic PA (sPA) is proposed to provide information on cervical tissue such as total hemoglobin (blood perfusion), tissue oxygenation level, and more importantly the collagen-to-water ratio in tissue. Shear wave elastography (SWE) measurements of cervical tissue indicates the correlation between cervical ripening and lower tissue elasticity. Our custom-designed imaging system consists of an endovaginal US transducer (ATL C9-5) capable of performing high frame rate US and acoustic radiation force shear wave imaging, and an optimized fiber-optic light delivery system’s for PA imaging. Our experimental results indicate the system’s ability to measure the presence of different concentrations of hemoglobin in tissue-mimicking phantoms as well as accurate measurement of hemoglobin oxygen saturation (SO2). In another set of experiments, we demonstrated the feasibility of monitoring collagen-to-water ratio in tissues through monitoring changes in sPA signature between 1100 and 1650 nm. Monitoring the variations of collagen in cervical tissue can help to predict sPTB.


Ultrasound in Obstetrics & Gynecology | 2007

OP12.09: The value of the sagittal view of the ‘ductal arch plane’ in the prenatal diagnosis and counseling of conotruncal anomalies using 4D ultrasonography

Jimmy Espinoza; Roberto Romero; Juan Pedro Kusanovic; Francesca Gotsch; W. Lee; L. F. Gonçalves; Offer Erez; M. L. Schoen; Sonia S. Hassan

Objectives: Transposition of the great arteries is still one of the challenging cardiac defects to detect prenatally. The aim of the study was to ascertain whether 4D ultrasound (STIC) in combination with ultrasound tomography can be of help in facilitating the detection of fetuses with TGA. Methods: STIC volumes from 12 fetuses with TGA between 21 and 36 weeks were analyzed offline starting from the four-chamber view plane in a dorsoposterior fetal position and applying tomographic imaging evaluation (TUI). Results: In all 12 cases a demonstration of the known parallel course of both aorta and pulmonary trunk was possible using TUI. From the standardized four-chamber view plane this was achieved by performing a translation movement cranially and a rotation toward the right shoulder of the fetus. The translation distance was 4-mm (20–25 weeks), 5-mm (25–30 weeks) and 6-mm (30–36 weeks) depending on gestational age. The rotation was between 27◦ and 50◦ but did not depend on gestational age but on the position of the vessels to each other. Conclusions: STIC with TUI provides important information on the spatial relationship of the great vessels in fetuses with TGA. When TGA is suspected the examiner could move the transducer from the four-chamber view 4–6-mm toward the upper thorax before tilting the probe 25–50◦ to demonstrate whether the vessels are in parallel course or not. Whether this easy move can help in routine screening to detect fetuses with TGA remains to be shown.


Journal of Perinatal Medicine | 2010

The prognosis of pregnancy conceived despite the presence of an intrauterine device (IUD)

Sun Kwon Kim; Roberto Romero; Juan Pedro Kusanovic; Offer Erez; Edi Vaisbuch; Shali Mazaki-Tovi; Francesca Gotsch; Pooja Mittal; Tinnakorn Chaiworapongsa; Percy Pacora; Giovanna Ogge; Ricardo Gomez; Bo Hyun Yoon; Lami Yeo; Ronald F. Lamont; Sonia S. Hassan


Archive | 2007

The Fetal Inflammatory Syndrome

Francesca Gotsch; Roberto Romero; Shali Mazaki-Tovi; Beth L. Pineles; Offer Erez; Jimmy Espinoza; Sonia S. Hassan


Archive | 2016

Kits and methods to distinguish false labor and true labor

Adi L. Tarca; Piya Chaemsaithong; Tinnakorn Chaiworapongsa; Sonia S. Hassan; Roberto Romero


Archive | 2014

Imaging of the uterine cervix

Sonia S. Hassan; Tinnakorn Chaiworapongsa; Jennifer Lam-Rachlin; Amy Whitten; Edgar Hernandez-Andrade; Roberto Romero


Revista del Hospital Materno Infantil Ramón Sardá | 2012

LA ADMINISTRACIÓN DE PROGESTERONA POR VÍA VAGINAL A MUJERES CON ACORTAMIENTO DEL CUELLO UTERINO ASINTOMÁTICO DETECTADO POR ECOGRAFÍA EN EL SEGUNDO TRIMESTRE DISMINUYE EL PARTO PRETÉRMINO Y LA MORBILIDAD NEONATAL: REVISIÓN SISTEMÁTICA Y METAANÁLISIS DE DATOS DE PACIENTES INDIVIDUALES

Roberto Romero; Kypros H. Nicolaides; Agustin Conde-Agudelo; Ann Tabor; John O'Brien; Elcin Cetingoz; Eduardo Da Fonseca; George W. Creasy; Katharina Klein; Line Rode; Priya Soma-Pillay; Shalini Fusey; Cetin Cam; Zarko Alfirevic; Sonia S. Hassan

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Roberto Romero

National Institutes of Health

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Offer Erez

Ben-Gurion University of the Negev

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Juan Pedro Kusanovic

Pontifical Catholic University of Chile

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Zhong Dong

Wayne State University

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