Sonja Rohrmann

Effects of Choir Singing or Listening on Secretory Immunoglobulin A, Cortisol, and Emotional State

The present study investigates the effects of choir music on secretory immunoglobulin A (S-IgA), cortisol, and emotional states in members of a mixed amateur choir. Subjects participated in two conditions during two rehearsals 1 week apart, namely singing versus listening to choral music. Saliva samples and subjective measures of affect were taken both before each session and 60 min later. Repeated measure analyses of variance were conducted for positive and negative affect scores, S-IgA, and cortisol. Results indicate several significant effects. In particular, singing leads to increases in positive affect and S-IgA, while negative affect is reduced. Listening to choral music leads to an increase in negative affect, and decreases in levels of cortisol. These results suggest that choir singing positively influences both emotional affect and immune competence. The observation that subjective and physiological responses differed between listening and singing conditions invites further investigation of task factors.

Symptom provocation and reduction in patients suffering from spider phobia

Neurofunctional mechanisms underlying cognitive behavior therapy (CBT) are still not clearly understood. This functional magnetic resonance imaging (fMRI) study focused on changes in brain activation as a result of one-session CBT in patients suffering from spider phobia. Twenty-six female spider phobics and 25 non-phobic subjects were presented with spider pictures, generally disgust-inducing, generally fear-inducing and affectively neutral scenes in an initial fMRI session. Afterwards, the patients were randomly assigned to either a therapy group (TG) or a waiting list group (WG). The scans were repeated one week after the treatment or after a one-week waiting period. Relative to the non-phobic participants, the patients displayed increased activation in the amygdala and the fusiform gyrus as well as decreased activation in the medial orbitofrontal cortex (OFC) during the first exposure. The therapy effect consisted of increased medial OFC activity in the TG relative to the WG. Further, therapy-related reductions in experienced somatic anxiety symptoms were positively correlated with activation decreases in the amygdala and the insula. We conclude that successful treatment of spider phobia is primarily accompanied by functional changes of the medial OFC. This brain region is crucial for the self-regulation of emotions and the relearning of stimulus-reinforcement associations.

Cardiovascular indicators of disgust

A bradycardia and an increasing parasympathetic activity are often recommended as characteristic physiological disgust reactions. However, findings concerning the influence of disgust on heart rate and autonomic control are heterogenous. Apart from this, only a few studies examined cardiovascular reactions to disgust, besides heart rate. The aim of this study is a differentiated description of cardiovascular reactions going along with disgust using impedance cardiography. Moreover, it will be surveyed if different cardiovascular responses are associated with content-specific disgust-inductions. One-hundred subjects watched three films: A neutral film (screensaver), a filmclip showing an amputation of the upper extremity and a filmclip displaying a person who is vomiting. The latter films are regarded as disease- and food-related disgust stimuli respectively, representing two superior disgust domains. Subjective, electrodermal and cardiovascular reactions to these films were compared using Repeated Measures ANOVAs. Strong subjective, electrodermal and cardiovascular reactions towards the filmclips with disgusting content were observed. The cardiovascular reactions of the disease- and food-related disgust stimuli differed in subjective and physiological parameters. Thus, a decrease in heart rate could only be observed as a response to disease-related disgust-induction. The observed differences are discussed as an endorsement for a domain-specific organisation of disgust reactions.

Implicit but Not Explicit Affectivity Predicts Circadian and Reactive Cortisol: Using the Implicit Positive and Negative Affect Test

Self-report measures assess mental processes or representations that are consciously accessible. In contrast, implicit measures assess automatic processes that often operate outside awareness. Whereas self-report measures have often failed to show expected relationships with endocrine stress responses, little effort has been made to relate implicit measures to endocrine processes. The present work examines whether implicit affectivity as assessed by the Implicit Positive and Negative Affect Test (IPANAT) predicts cortisol regulation. In Study 1, implicit low positive affectivity, but not negative affectivity, significantly predicted circadian cortisol release. In Study 2, implicit negative affectivity, but not positive affectivity, significantly predicted the cortisol response to acute stress. By contrast, cortisol regulation was not predicted by self-reported affectivity. The findings support the use of implicit affectivity measures in studying individual differences in endocrine stress responses and point to a differential role of positive and negative affectivity in baseline versus stress-contingent cortisol release, respectively.

Changing psychobiological stress reactions by manipulating cognitive processes

This study aimed at manipulating psychobiological reactions to public speaking stress by means of verbal comments during the anticipation period. Sixty male students were instructed to give a public talk in 10 min. Twenty subjects each were randomly assigned to one of three experimental conditions: During anticipation of the speech the experimenter remained silent in the control condition, gave feedback that the subject was physiologically aroused and nervous in the second (arousing manipulation), or that he was physiologically calm and relaxed in the third condition (reassuring manipulation). Within the three stress conditions heart rate, systolic blood pressure, cortisol, and electrodermal responses were highest in the condition with reassuring manipulation and lowest in the condition without manipulation. Emotional stress reactions were highest in the condition with arousing manipulation and lowest in the condition with reassuring manipulation. Compared to the group without manipulation clear intraindividual discrepancies between emotional and somatic stress reactions could be observed in the group with reassuring manipulation (emotional < somatic arousal) and the group with arousing manipulation (emotional > somatic arousal). The two groups were significantly different in their discrepancy scores. It was concluded that the arousing manipulation seemed to have induced a sensitive, the reassuring manipulation a defensive coping style.

Gender Differences in Psychophysiological Responses to Disgust

Several studies have revealed that women report stronger feelings of disgust than men (Gross & Levenson, 1995; Schienle, Schafer, Stark, Walter, & Vaitl, 2005). However, the extent to which this gender difference also influences physiological disgust responses remains an open question. In Experiment 1, 54 female and 41 male participants were exposed to slides of different disgust-content. In Experiment 2, 47 women and 53 men watched two film clips showing hygiene-related or food-related disgust stimuli, respectively. Differences between males and females in reported and physiological disgust responses (heart rate, electrodermal activity, salivary cortisol, secretory immunoglobulin A) were tested by analysis of variance. Replicating previous studies, women reported stronger feelings of disgust than men across all disgust inductions. Additionally, in Study 1, women showed a higher increase in skin conductance level than men. In conclusion, gender moderates subjective responses to disgust, whereas physiologi...

Endocrine responses after d-fenfluramine and ipsapirone challenge : Further support for cloninger's tridimensional model of personality

The tridemensional model of personality introduced by Cloninger relates aspects of novelty seeking to the dopaminergic, harm avoidance (HA) to the serotonergic, and reward dependence to the noradrenergic neurotransmitter system. Using a neuroendocrine challenge paradigm, this study investigates whether subjects characterized by blunted cortisol (CORT) responses after ipsapirone (IPS) relate to different subfactors of HA from those characterized by blunted prolactin (PRL) responses after treatment with d-fenfluramine (D-FEN). Moreover, subjects blunted in both responses should differ in scale values of subfactors of HA from those with only one or no blunted reactions. In the first part of the experiment, 16 healthy male volunteers were treated with 15 mg D-FEN. The second part of the study (about 1 year later) consists of a challenge with the partial 5-hydroxytryptamine-1a (5-HT1a) agonist IPS (10 mg) in the same subjects. The results indicate that blunted PRL responses are accompanied by high values in HA, while the main effect of IPS responsivity did not relate significantly to this dimension. With respect to the subscales of HA, subjects blunted in both responses (PRL–/C–) exhibit significantly higher levels in fatigability and asthenia when compared to all other groups (PRL–/C+, PRL+/C–,PRL+/C+). The data demonstrate that combined challenge tests may shed more light on the biological basis of personality and that HA and most clearly fatigability and asthenia relate to the 5-HT system.

Reboxetine in a neuroendocrine challenge paradigm: evidence for high cortisol responses in healthy volunteers scoring high on subclinical depression

This paper investigates if the highly selective norepinephrine reuptake inhibitor reboxetine leads to a dose-dependent cortisol release and if this response depends on personality dimensions related to clinical depression in healthy volunteers. Twenty-four male subjects received placebo, 2 mg, or 4 mg reboxetine in a balanced, randomized cross-over study. Cortisol was measured in saliva at six different time-points according to the kinetics of the drug. Furthermore, several measurements of cardiovascular parameters, emotional states, and possible side-effects were obtained. Subjects were divided into two groups scoring above or below the median of a depressiveness questionnaire scale [n = 11, low (D-); n = 13, high (D+)]. Results clearly demonstrated, that reboxetine stimulates cortisol release. Whereas blood pressure was not affected, heart rate increased after 2 and 4 mg but not dose dependently. Subjects reported more non-specific arousal while the dimensions of tiredness-wakefulness and positive-negative emotional states were not affected by the drug. Somatic complaints were low and only non-specific complaints were statistically elevated but of negligible amount. Subjects classified as D+ can be characterized as high responders to the drug. This is especially true not only for cortisol increases but also for changes in heart rate and some ratings on physical complaints. Hot flushes, sweating and a throbbing sensation in blood vessels in the head were observed in D+ but only with the 4 mg dose. The results clearly demonstrate that reboxetine stimulates cortisol release and heart rate and that this is particularly pronounced in subjects scoring high on depression-related personality dimensions. Reboxetine, therefore, is a promising tool for investigating neuroendocrine response to noradrenergic challenge tests. The question whether increased responses in D+ are due to an up-regulation of receptor sensitivity as a consequence of low norepinephrine supply is discussed.

Modification of experimentally induced aggression by temperament dimensions

Abstract The present paper investigates the question of how experimentally induced aggression can be modified by different temperament dimensions, and if subjects scoring high on different aspects of temperament differ with respect to responses to a serotonergic drug, since serotonin responses have been shown to be related to impulsivity and aggression. In a sample of 40 healthy males divided either according to the temperament dimension of Tempo or Lack of Impulse Control as measured by the EASI Temperament Inventory were randomly assigned to four groups of a 2×2 design comprising the factors of ipsapirone\placebo and experimental induction of aggression by a modified Master Mind game and a control condition. Emotional, behavioral, and hormone responses were recorded. The major findings were that induction of aggression increased emotional aggression in high Tempo scorers (high T) and behavioral aggression (punishing a putative coplayer by noise) in high scorers on Lack of Impulse Control (high LIC). The serotonergic drug induced anger in high T under control conditions but reduced it upon experimental induction of aggression, whereas the opposite held true in high LIC. The hormone responses (cortisol and prolactin) to the drug under control and aggression induction conditions were also different for high T and high LIC. Results were interpreted in terms of different receptor sensitivities of the serotonergic and the dopaminergic system in the two temperament groups.

Emotion regulation, disgust sensitivity, and psychophysiological responses to a disgust-inducing film.

Abstract Using a disgust-inducing film, Gross (1998) showed that the instruction to suppress mimic expression (suppression) triggered physiological arousal, while the instruction to think about the film in order to adopt a detached and unemotional attitude (reappraisal) reduced affective strain compared to a condition instructing subjects simply to watch the film (watch). The present paper investigates, if disgust sensitivity has a moderating role in this context. Physiological, subjective, and behavior responses were recorded in 120 males divided according to high/low disgust sensitivity who were exposed to the disgust-inducing film used by Gross. The instruction effects reported by Gross could not be replicated. However, high disgust-sensitive subjects were more physiologically and emotionally aroused than low disgust-sensitive subjects. Interactions between disgust sensitivity and the three film instructions can possibly be traced back to a repressive coping style of subjects with low disgust sensitivity.