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Featured researches published by Soo-Ok Kim.


Clinical Cancer Research | 2008

Efficacy of Gemcitabine in Patients with Non–Small Cell Lung Cancer According to Promoter Polymorphisms of the Ribonucleotide Reductase M1 Gene

Soo-Ok Kim; Ju-Yeon Jeong; Mi-Ran Kim; Hyun-Ju Cho; Jin-Yung Ju; Yong-Soo Kwon; In-Jae Oh; Kyu-Sik Kim; Yu-Il Kim; Sung-Chul Lim; Young-Chul Kim

Purpose: High ribonucleotide reductase M1 (RRM1) expression in resected lung cancers has been associated with better clinical outcomes. However, gemcitabine-treated patients with high tumoral RRM1 expression generally evidence poor prognoses due to the decreased efficacy of gemcitabine therapy. This study was designed in accordance with the hypothesis that polymorphisms (−37 and −524) of the RRM1 promoter gene sequence, which regulate RRM1 expression, could influence the efficacy and prognosis of lung cancer patients treated with gemcitabine-based chemotherapy. Experimental Design: A retrospective dataset of 97 patients with advanced non–small cell lung cancer treated with gemcitabine regimens as a first-line treatment was studied in this work. The allelotyping of RRM1 promoter polymorphisms was conducted via real-time PCR using genomic DNA obtained from peripheral WBC. Results: The RRM1 promoter allelotype was RR37CC-R524TT in 58 patients, RR37AC-RR524CT in 29 patients, and other allelotypes in 10 patients. The response rate for gemcitabine-containing chemotherapy was 49.5%. The response rate was significantly higher in the RR37AC-RR524CT group (65.5%) compared with the group containing other allelotypes (42.6%; P = 0.039). Overall survival and progression-free survival did not differ significantly by allelotype. Conclusions: We detected significant differences in response rates to gemcitabine-based chemotherapy according to the allelotypes of the RRM1 promoter sequence, which could be determined using the germline DNA. Further functional and clinical studies will be required before this can be used as a predictive marker.


Tuberculosis and Respiratory Diseases | 2011

Comparison of Therapeutic Efficacy of Gefitinib and Erlotinib in Patients with Squamous Cell Lung Cancer

Hong-Joon Shin; Su-Young Chi; Hee-Jung Ban; Soo-Ok Kim; Yong-Soo Kwon; In-Jae Oh; Kyu-Sik Kim; Yu-Il Kim; Sung-Chul Lim; Young-Chul Kim


Journal of Thoracic Oncology | 2017

P1.12-001 Flexible Bronchoscopic Cryotherapy in Patients with Malignant Central Airway Obstruction

Sung Kyoung Kim; Y.M. Ko; Soo-Ok Kim; So Hyang Song; Chi Hong Kim


Tuberculosis and Respiratory Diseases | 2012

A Case of Miliary Brain Metastasis of Lung Cancer Mimicking Neurocysticercosis

Ho-Jun Lee; In-Jae Oh; Sang-Woo Park; Hee-Jung Ban; Young-Chul Kim; Soo-Ok Kim


American Journal of Case Reports | 2011

Lymphangioleiomyomatosis presented by pulmonary nodules

Soo-Ok Kim; In-Jae Oh; Yoo-Duk Choi; Song Choi; Sang-Yun Song; Kyu-Sik Kim; Kook-Joo Na


Tuberculosis and Respiratory Diseases | 2010

Significance of Repeated Polymerase Chain Reaction (PCR) Testing for Diagnosis of Pulmonary Tuberculosis

Soo-Ok Kim; Yoon-Hee Kim; Su-Young Chi; Hee-Jung Ban; In-Jae Oh; Yong-Soo Kwon; Kyu-Sik Kim; Yu-Il Kim; Sung-Chul Lim; Young-Chul Kim


Tuberculosis and Respiratory Diseases | 2010

A Case of Successful Management of Lung Cancer Pain Using Ultrahigh-dose Fentanyl Patch

Soo-Ok Kim; Min-Jee Kim; Yong-Soo Kwon; Sung-Chul Lim; Hee-Jung Ban; In-Jae Oh; Kyu-Sik Kim; Young-Chul Kim


Tuberculosis and Respiratory Diseases | 2010

A Case of Rectus Sheath Hematoma Complicated with Hypovolemic Shock in a Critically-Ill Patient

Hong-Joon Shin; Yoon-Hee Kim; Su-Young Chi; Hee Jung Ban; Yong-Soo Kwon; In-Jae Oh; Kyu-Sik Kim; Sung-Chul Lim; Young-Chul Kim; Soo-Ok Kim


Journal of Thoracic Oncology | 2007

Prediction of response to gemcitabine with polymorphisms of RRM1 gene: P2-269

Young-Chul Kim; Soo-Ok Kim; Kyu-Sik Kim; In-Jae Oh; Yu-Il Kim; Sung-Chul Lim; Kyung-Ok Park; Jung-Hwan Lim; Jin-Young Ju; Gye-Jung Cho; Don-Ryeol Chae; Mi-Ran Kim; Hyun-Ju Cho


Journal of Thoracic Oncology | 2007

P2-269: Prediction of response to gemcitabine with polymorphisms of RRM1 gene

Young-Chul Kim; Soo-Ok Kim; Kyu-Sik Kim; In-Jae Oh; Yu-Il Kim; Sung-Chul Lim; Kyung-Ok Park; Jung-Hwan Lim; Jin-Young Ju; Gye-Jung Cho; Don-Ryeol Chae; Mi-Ran Kim; Hyun-Ju Cho

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In-Jae Oh

Chonnam National University

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Kyu-Sik Kim

Chonnam National University

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Young-Chul Kim

Chonnam National University

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Yu-Il Kim

Chonnam National University

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Yong-Soo Kwon

Chonnam National University

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Hee-Jung Ban

Chonnam National University

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Hyun-Ju Cho

Chonnam National University

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Jung-Hwan Lim

Chonnam National University

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Mi-Ran Kim

Chonnam National University

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