Soo-Ok Kim
Chonnam National University
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Publication
Featured researches published by Soo-Ok Kim.
Clinical Cancer Research | 2008
Soo-Ok Kim; Ju-Yeon Jeong; Mi-Ran Kim; Hyun-Ju Cho; Jin-Yung Ju; Yong-Soo Kwon; In-Jae Oh; Kyu-Sik Kim; Yu-Il Kim; Sung-Chul Lim; Young-Chul Kim
Purpose: High ribonucleotide reductase M1 (RRM1) expression in resected lung cancers has been associated with better clinical outcomes. However, gemcitabine-treated patients with high tumoral RRM1 expression generally evidence poor prognoses due to the decreased efficacy of gemcitabine therapy. This study was designed in accordance with the hypothesis that polymorphisms (−37 and −524) of the RRM1 promoter gene sequence, which regulate RRM1 expression, could influence the efficacy and prognosis of lung cancer patients treated with gemcitabine-based chemotherapy. Experimental Design: A retrospective dataset of 97 patients with advanced non–small cell lung cancer treated with gemcitabine regimens as a first-line treatment was studied in this work. The allelotyping of RRM1 promoter polymorphisms was conducted via real-time PCR using genomic DNA obtained from peripheral WBC. Results: The RRM1 promoter allelotype was RR37CC-R524TT in 58 patients, RR37AC-RR524CT in 29 patients, and other allelotypes in 10 patients. The response rate for gemcitabine-containing chemotherapy was 49.5%. The response rate was significantly higher in the RR37AC-RR524CT group (65.5%) compared with the group containing other allelotypes (42.6%; P = 0.039). Overall survival and progression-free survival did not differ significantly by allelotype. Conclusions: We detected significant differences in response rates to gemcitabine-based chemotherapy according to the allelotypes of the RRM1 promoter sequence, which could be determined using the germline DNA. Further functional and clinical studies will be required before this can be used as a predictive marker.
Tuberculosis and Respiratory Diseases | 2011
Hong-Joon Shin; Su-Young Chi; Hee-Jung Ban; Soo-Ok Kim; Yong-Soo Kwon; In-Jae Oh; Kyu-Sik Kim; Yu-Il Kim; Sung-Chul Lim; Young-Chul Kim
Journal of Thoracic Oncology | 2017
Sung Kyoung Kim; Y.M. Ko; Soo-Ok Kim; So Hyang Song; Chi Hong Kim
Tuberculosis and Respiratory Diseases | 2012
Ho-Jun Lee; In-Jae Oh; Sang-Woo Park; Hee-Jung Ban; Young-Chul Kim; Soo-Ok Kim
American Journal of Case Reports | 2011
Soo-Ok Kim; In-Jae Oh; Yoo-Duk Choi; Song Choi; Sang-Yun Song; Kyu-Sik Kim; Kook-Joo Na
Tuberculosis and Respiratory Diseases | 2010
Soo-Ok Kim; Yoon-Hee Kim; Su-Young Chi; Hee-Jung Ban; In-Jae Oh; Yong-Soo Kwon; Kyu-Sik Kim; Yu-Il Kim; Sung-Chul Lim; Young-Chul Kim
Tuberculosis and Respiratory Diseases | 2010
Soo-Ok Kim; Min-Jee Kim; Yong-Soo Kwon; Sung-Chul Lim; Hee-Jung Ban; In-Jae Oh; Kyu-Sik Kim; Young-Chul Kim
Tuberculosis and Respiratory Diseases | 2010
Hong-Joon Shin; Yoon-Hee Kim; Su-Young Chi; Hee Jung Ban; Yong-Soo Kwon; In-Jae Oh; Kyu-Sik Kim; Sung-Chul Lim; Young-Chul Kim; Soo-Ok Kim
Journal of Thoracic Oncology | 2007
Young-Chul Kim; Soo-Ok Kim; Kyu-Sik Kim; In-Jae Oh; Yu-Il Kim; Sung-Chul Lim; Kyung-Ok Park; Jung-Hwan Lim; Jin-Young Ju; Gye-Jung Cho; Don-Ryeol Chae; Mi-Ran Kim; Hyun-Ju Cho
Journal of Thoracic Oncology | 2007
Young-Chul Kim; Soo-Ok Kim; Kyu-Sik Kim; In-Jae Oh; Yu-Il Kim; Sung-Chul Lim; Kyung-Ok Park; Jung-Hwan Lim; Jin-Young Ju; Gye-Jung Cho; Don-Ryeol Chae; Mi-Ran Kim; Hyun-Ju Cho