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Publication
Featured researches published by Sookie La.
Journal of Pharmaceutical Investigation | 2010
Yun Young Lee; Hye Jin Kim; Sookie La; Kyung Hee Cho; Moon Sun Jang; Young Joon Park; Hee Joo Lee
A bioequivalence study of LANIDIEM tablet 4 mg (Samil. Co., Ltd.) to Vaxar tablet 4 mg (GlaxoSmithKline Co., Ltd.) was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Forty healthy male Korean volunteers were enrolled in the study and thirty six volunteers completed the study according to the protocol. Thirty six volunteers received each medicine at the lacidipine dose of 4 mg in a crossover study. There was one week wash-out period between the doses. Plasma concentrations of lacidipine were monitored by a high performance liquid chromatography - tandem mass spectrometry (LC-MS/MS) for over a period of 24 hours after drug administration. (the area under the plasma concentration-time curve from time zero to 24 hr) was calculated by the linear trapezoidal rule method. (maximum plasma drug concentration) and (time to reach ) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed and . No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the ratio and the ratio for LANIDIEM/Vaxar were log 0.8102~log 1.0417 and log 0.8493~log 1.1439, respectively. These values were within the acceptable bioequivalence intervals of log 0.80~log 1.25. Thus, our study demonstrated the bioequivalence of LANIDIEM tablet 4 mg and Vaxar tablet 4 mg with respect to the rate and extent of absorption.
Journal of Pharmaceutical Investigation | 2007
Seung-Kwon Yang; Sookie La; Kyu-Young Chang; Yun-Young Lee; Mi-Kyeong Yoon; Soo-Hyun Lew; Kyung-Ryul Lee; Hee-Joo Lee
A bioequivalence study of soft capsule (Medica Korea Pharma. Co., Ltd.) to soft capsule (Roche Korea Ind. Co., Ltd.) was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Thirty healthy male Korean volunteers received each medicine at the isotretinoin dose of 60 mg in a crossover study. There was one week wash-out period between the doses. Plasma concentrations of isotretinoin were monitored by a high performance liquid chromatography (HPLC) for over a period of 48 hours after drug administration. (the area under the plasma concentration-time curve from time zero to 48 hr) was calculated by the linear trapezoidal rule method. (maximum plasma drug concentration) and (time to reach ) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed . No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the ratio and the ratio for were , respectively. These values were within the acceptable bioequivalence intervals of . Thus, our study demonstrated the bioequivalence of with respect to the rate and extent of absorption.
Biomedical Chromatography | 2016
Min-Ho Park; Yun Young Lee; Kyung Hee Cho; Sookie La; Hee Joo Lee; Dong-Seok Yim; Sooho Ban; Moon-Young Park; Yong-Chul Kim; Yoon-Gyoon Kim; Young G. Shin
Analytical Science and Technology | 2008
Moon-Sun Jang; Sookie La; Kyu Young Chang; Seung Woo Kang; Sang Beom Han; Kyung Ryul Lee; Hee Joo Lee
Drug Metabolism and Pharmacokinetics | 2017
Sun Koung Joung; So Young Kang; Kyung Na Ma; Sun A. Kim; Kyunghee Cho; Sookie La; Hee Joo Lee
Drug Metabolism and Pharmacokinetics | 2017
Kyunghee Cho; Sun Koung Joung; Sookie La; Dae-Young Lee; Hyun Joo Shim; Ji Su Song; Hee Joo Lee
한국분석과학회 학술대회 | 2010
Sun Koung Joung; Kyung Hee Cho; Sookie La; Hee Joo Lee
한국분석과학회 학술대회 | 2010
Hye Jin Kim; Sun Koung Joung; Kyung Hee Cho; Sookie La; Hee Joo Lee
한국분석과학회 학술대회 | 2009
Jeong Jin Yun; Sun Koung Joung; Kyung Hee Cho; Sookie La; Hee Joo Lee
한국분석과학회 학술대회 | 2009
Jae Woo Song; Sun Koung Joung; Kyung Hee Cho; Sookie La; Hee Joo Lee